Article
Engineering, Biomedical
Wenjing Zhang, Lingting Zeng, Huan Yu, Ziheng He, Cuishan Huang, Cairong Li, Yangyi Nie, Long Li, Feifei Zhou, Ben Liu, Yuantao Zhang, Zhenyu Yao, Wei Zhang, Ling Qin, Di Chen, Qianjun He, Yuxiao Lai
Summary: This study developed an injectable calcium boride nanosheets (CBN) loaded hydrogel platform (CBN@GelDA hydrogel) as a high-payload and sustainable hydrogen (H2) precursor for osteoarthritis (OA) treatment. The CBN@GelDA hydrogel maintained constant physiological pH conditions, released more H2 than CBN alone, and lasted for more than one week. The hydrogel had ROS scavenging ability, reduced inflammatory cytokine expression, stimulated M2 macrophages, and decreased chondrocyte apoptosis, effectively alleviating the progression of OA.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Bing Wu, Elena Pascu, Sarah A. Brady, Dermot F. Brougham, Owen M. Clarkin
Summary: A novel synthetic approach for injectable hydrogels was designed, with the ability to control setting time and mechanical properties by adjusting the chemical composition. The study also revealed a positive correlation between the Ca/Al ratio and the hardening time and mechanical strength of alginate gels.
MATERIALS & DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Lumin Yang, Xiaoduo Zhao, Yunsong Kong, Renjie Li, Tao Li, Rui Wang, Zhengfeng Ma, Yong-min Liang, Shuanhong Ma, Feng Zhou
Summary: In this study, a novel macromolecular/microsphere-based injectable hydrogel (CMC-ODex NPs) was developed for dual functionalities of drug release and lubrication. The hydrogel exhibited viscosity-thinning phenomenon and gel-sol transition feature, resulting in low friction coefficient at the sliding interface of articular cartilages. The encapsulated anti-inflammatory drug (dexamethasone, DXM) in the hydrogel showed sustainable drug release, leading to good and stable anti-inflammatory effect.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Zhuoer Wang, Aiyou Hao, Pengyao Xing
Summary: This study reports a general method to build hydrogels from pi-conjugated amino acids with charge-transfer complexes, allowing for tunable response to circularly polarized light. The hybrid hydrogels showed adjustable photothermal performance and tunable Cotton effects from visible light to NIR-I region.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Characterization & Testing
Ziyuan Fang, Kun Qiao, Yansen Wang, Yudong Zheng, Wei He, Yajie Xie, Huiyi Yang
Summary: Alginate hydrogels have been extensively studied as an injectable system with unique physical and biological properties. By developing a new injectable nanocomposite alginate hydrogel and utilizing specific methods and equipment, researchers were able to regulate the sol-gel transition and evaluate degradation behavior effectively, leading to improved mechanical properties and potential application in tissue engineering.
Article
Chemistry, Physical
Elizaveta Anastasova, Anastasia A. Belyaeva, Sergey A. Tsymbal, Denis A. Vinnik, Vladimir V. Vinogradov
Summary: This study develops a stable magnetite hydrosol and successfully synthesizes materials with different structures by controlling the concentrations and drying conditions. The effects are theoretically explained and the synthesized materials show excellent biocompatibility and hemostatic potential.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Polymer Science
Yikun Ren, Dan Zhang, Yuanmeng He, Rong Chang, Shen Guo, Shanshan Ma, Minghao Yao, Fangxia Guan
Summary: Hydrogels with injectable and antioxidant properties, such as the HT/QGA hydrogel prepared in this study, show promising qualities for wound healing. The hydrogel exhibited excellent injectability, favorable antioxidant activity, and good biocompatibility, and showed potential application in wound healing in a full-thickness skin injury model.
Article
Nanoscience & Nanotechnology
Kunbao Zhang, Chao Yang, Chuanxu Cheng, Chengxin Shi, Madi Sun, Hanze Hu, Tongfei Shi, Xuenian Chen, Xuan He, Xiao Zheng, Mingqiang Li, Dan Shao
Summary: A bioactive hydrogel is developed for efficient and safe bacteria-infected diabetic wound healing by targeting inflammation and infection. The hydrogel can capture danger molecules and deliver antibiotics, resulting in improved wound closure rate and anti-inflammatory and antibacterial effects.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Kunbao Zhang, Chao Yang, Chuanxu Cheng, Chengxin Shi, Madi Sun, Hanze Hu, Tongfei Shi, Xuenian Chen, Xuan He, Xiao Zheng, Mingqiang Li, Dan Shao
Summary: This study introduces a bioactive hydrogel, named OCMC-Tob/PEI hydrogel, for the treatment of infected wounds in patients with chronic diabetes. The hydrogel achieves dual effects of anti-inflammation and anti-infection by scavenging danger molecules and releasing antibiotics.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Yajie Zhong, Farzad Seidi, Yilin Wang, Ling Zheng, Yongcan Jin, Huining Xiao
Summary: An injectable self-healing hydrogel with inherent antibacterial activity was developed by forming dynamic covalent bonds between boronic acid and catechol groups in quaternized chitosan, along with encapsulating EGCG. The hydrogels showed excellent dual functions of antibacterial and antioxidant properties, and demonstrated good biocompatibility and contact-active antibacterial activity. In vivo evaluation showed the hydrogels' regenerative wound healing performance, highlighting their potential as novel wound dressings for wound management.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Longlong Cui, Jiankang Li, Shuaimeng Guan, Kaixiang Zhang, Kun Zhang, Jingan Li
Summary: In this study, a multi-functional injectable hydrogel was prepared and its antioxidant, gelation time, degradability, rheology, and antihemorrhagic properties were finely tuned by varying the composition ratio. The hydrogel was found to promote angiogenesis and cell proliferation, and regulate inflammation to enhance the repair of full-thickness skin injuries.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Yikun Ren, Shanshan Ma, Dan Zhang, Shen Guo, Rong Chang, Yuanmeng He, Minghao Yao, Fangxia Guan
Summary: An injectable hyaluronic acid hydrogel with antioxidative and photothermal antibacterial activity has been developed as a functional dressing for infected wounds. This hydrogel demonstrates good stability, biocompatibility, and effective prevention of early infection and acceleration of wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Multidisciplinary
Chen Zhou, Ruiling Xu, Xiaowen Han, Lei Tong, Li Xiong, Jie Liang, Yong Sun, Xingdong Zhang, Yujiang Fan
Summary: Injectable antioxidant hydrogels composed of protocatechuic acid (PA)-mediated carboxylated chitosan (CCS) and oxidized hyaluronic acid (OHA) conjugate were designed to reduce oxidative stress and promote wound healing. These hydrogels exhibited stable chemical structure, satisfactory physical properties, and effective antibacterial properties. In addition, the hydrogels demonstrated significant antioxidant capacity and promoted collagen deposition in wound healing in animal tests.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Rong Yang, Wenliang Xue, Huiyun Liao, Fubin Wu, Hao Guo, Wenjie Zhang, Penghui Wang, Xiaoyan Tan, Hong Xu, Bo Chi
Summary: A multifunctional hydrogel dressing with antibacterial and antioxidative properties was fabricated to promote skin tissue regeneration and wound healing. The hydrogel possessed tunable gelation time, good tissue adhesiveness, and activity to improve collagen deposition and angiogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Stanislas Le Guisquet, Marco Amabili
Summary: This study characterizes the viscoelastic properties of a hydrogel in sol-gel transition by measuring the vibration response of a rigid circular cylindrical container's bottom silicone membrane. A finite-element numerical model was built for identification of the hydrogel's storage shear modulus and loss tangent. It was found that membrane vibration can be used to characterize the viscoelastic mechanical properties of a hydrogel in sol-gel transition in a more versatile way.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Article
Biochemistry & Molecular Biology
Toru Yoshitomi, Yukio Nagasaki
Summary: The newly developed redox nanoparticles (RNPs) as next-generation antioxidants show promising therapeutic effects in treating oxidative stress disorders such as kidney, cerebral, myocardial, and intestinal IR injuries by effectively scavenging ROS in damaged tissues.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Hiromi Kurokawa, Atsushi Taninaka, Toru Yoshitomi, Hidemi Shigekawa, Hirofumi Matsui
Summary: The use of nanoparticles, especially gold nanoparticles, as a new cancer treatment has been investigated. Gold nanoparticles can be modified to absorb near-infrared light, which can be used to treat deep-seated cancer in organs without causing damage. A study found that a gold compound attached to porphyrin, called Au-HpD, showed cancer-specific accumulation and cytotoxicity. When cancer cells were exposed to laser irradiation in the presence of Au-HpD, they underwent cell apoptosis, while normal cells were not affected.
Article
Materials Science, Biomaterials
Linawati Sutrisno, Huajian Chen, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: The study developed a bifunctional PLGA-collagen-BPNS composite scaffold with high mechanical strength, photothermal ablation capability, and promotion of skin tissue regeneration.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Yongtao Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: This study investigates the impact of cell density on gene transfection of mesenchymal stem cells. It shows that moderate cell density is beneficial for gene transfection, while low and high cell densities have negative effects. The influence of cell density on gene transfection is strongly correlated with its effect on cellular uptake capacity and DNA synthesis.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Polymer Science
Jing Zheng, Rui Sun, Huajian Chen, Tianjiao Zeng, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: Cell morphology can influence breast cancer cell resistance to anti-cancer drugs by affecting cytoskeletal organization, DNA synthesis activity, and P-glycoprotein expression. Larger breast cancer cells with better assembled actin filaments and higher DNA synthesis activity showed higher resistance to doxorubicin, suggesting a correlation between cell morphology and drug resistance.
Article
Cell Biology
Jurairat Khongrum, Pratoomporn Yingthongchai, Kongsak Boonyapranai, Wachira Wongtanasarasin, Nowwapan Donrung, Wanida Sukketsiri, Aree Prachansuwan, Pennapa Chonpathompikunlert
Summary: Oxidative stress and inflammation are important factors in dyslipidemia. The study found that consuming the RP jelly drink for 8 weeks significantly improved lipid profiles and oxidative stress, but had no significant impact on inflammation and glucose levels.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Natsumi Mori-Moriyama, Toru Yoshitomi, Naoki Sato
Summary: This study determined the structure of acyl plastoquinol, a novel compound found in cyanobacteria, using mass spectrometry, gas chromatography, and NMR. The level of acyl plastoquinol in total lipids was very low, and there is still no clear evidence for the presence of triacylglycerol. The potential roles of this compound in photosynthesis should be further investigated.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Rui Sun, Huajian Chen, Jing Zheng, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: Composite scaffolds consisting of gelatin modified with folic acid and citrate-modified Fe3O4 nanoparticles were fabricated to address the challenges in postsurgical treatment of breast cancer. The composite scaffolds had large spherical pores that allowed for cell entry and exit, and the folic acid-functionalized scaffolds were capable of capturing breast cancer cells. The Fe3O4/gelatin composites exhibited high magnetic-thermal conversion capacity for ablation of breast cancer cells under alternating magnetic field irradiation, while also promoting the growth and adipogenesis of mesenchymal stem cells.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Agriculture, Dairy & Animal Science
Kamonporn Panja, Sathita Areerat, Pipatpong Chundang, Pornsucha Palaseweenun, Nattaphong Akrimajirachoote, Jaruwan Sitdhipol, Punnathorn Thaveethaptaikul, Pennapa Chonpathompikunlert, Kanidta Niwasabutra, Pongsathon Phapugrangkul, Attawit Kovitvadhi
Summary: This study examined the effects of different strains of Lactobacillus on dogs' hematological indices, nutritional status, digestibility, enzyme activities, and immunity. The results showed that Lactobacillus plantarum CM20-8 (TISTR 2676), L. acidophilus Im10 (TISTR 2734), L. rhamnosus L12-2 (TISTR 2716), L. paracasei KT-5 (TISTR 2688), and L. fermentum CM14-8 (TISTR 2720), along with their mixture, are safe and non-pathogenic additives for use as new probiotic strains in dogs. However, no significant effects on the measured parameters were observed.
Article
Biochemistry & Molecular Biology
Van Thi Hong Doan, Yoshiki Komatsu, Hirofumi Matsui, Naoki Kawazoe, Guoping Chen, Toru Yoshitomi
Summary: Plasma membrane-targeted photodynamic therapy has gained attention as an effective cancer immunotherapeutic strategy. However, internalization of released photosensitizers in the cytosol hinders investigations of their effects on the plasma membrane. This study developed a cell culture dish with singlet oxygen-generating cell-adhesive glass surfaces, allowing investigation of the effects of photosensitizers attached to the plasma membrane.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yoshiki Komatsu, Toru Yoshitomi, Van Thi Hong Doan, Hiromi Kurokawa, Saori Fujiwara, Naoki Kawazoe, Guoping Chen, Hirofumi Matsui
Summary: This study developed a locally administered photodynamic therapy using nano-adhesive porphyrin as a photosensitizer. The locally administered photodynamic therapy showed a higher anti-tumor effect without phototoxicity compared to low-molecular-weight hematoporphyrin. Therefore, locally administered photodynamic therapy is a potential treatment with high therapeutic efficacy and no phototoxicity.
Article
Materials Science, Biomaterials
Jing Zheng, Huajian Chen, Chengyu Lu, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: This study used agarose hydrogel containers to encapsulate viscous media for 3D cell culture and found that viscosity affects gene expression and secretion of cartilaginous matrices in bovine articular chondrocytes (BACs), but does not affect cell proliferation.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Meeting Abstract
Cell & Tissue Engineering
Rui Sun, Naoki Kawazoe, Guoping Chen
TISSUE ENGINEERING PART A
(2022)
Article
Materials Science, Biomaterials
Huajian Chen, Rui Sun, Tianjiao Zeng, Jing Zheng, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: This study developed a smart platform for stepwise photothermal therapy (PTT) and chemotherapy, which effectively achieved synergistic effects of PTT and chemotherapy while minimizing damage to normal cells. The temperature and drug release from the composite scaffolds could be controlled, allowing for high local temperatures during PTT and controlled drug release during chemotherapy. In vitro and in vivo experiments demonstrated the strong synergistic effect of the combined therapy, with a mild hyperthermia effect after degradation of black phosphorus (BP). Additionally, the composite scaffolds supported the proliferation of mesenchymal stem cells after complete drug release.
BIOMATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Linawati Sutrisno, Huajian Chen, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen
Summary: Composite nanoparticles composed of black phosphorus nanosheets and gold nanostars were synthesized and combined with gelatin scaffolds to prepare gelatin-BP-AuNS composite scaffolds. The composite scaffolds exhibited excellent photothermal properties, promoting cell migration and distribution, eliminating cancer cells, and supporting stem cell differentiation, showing promise for breast cancer therapy.
BIOMATERIALS ADVANCES
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)