Review
Biochemistry & Molecular Biology
Yunwei Niu, Jiahe Wu, Yanxiang Kang, Pingli Sun, Zuobing Xiao, Di Zhao
Summary: Magnetic chitosan hydrogels are a type of organic-inorganic composite material that combines the characteristics of magnetic materials and natural polysaccharides. These hydrogels, which are made by adding magnetic nanoparticles to chitosan, have improved mechanical strength and exhibit magnetic thermal effects, targeting capabilities, magnetically-sensitive release characteristics, and easy separation and recovery. They have been used in various applications including drug delivery, magnetic resonance imaging, mag-netothermal therapy, and adsorption of heavy metals and dyes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Li Xie, Rong Liu, Jian Li, Ying Li, Jinfeng He, Mengyuan Zhang, Haijin Yang
Summary: This study constructs a multifunctional and self-adaptive double-layer hydrogel for irregular shape and deep wound repair. The inner layer hydrogel exhibits strong adaptability and therapeutic effect, while the outer layer hydrogel provides protection and a moist environment. The double-layer hydrogel promotes skin tissue regeneration and wound closure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Derya Aksu Demirezen, Dilek Demirezen Yilmaz, Yalcin Sevki Yildiz
Summary: In this study, robust and reusable magnetic chitosan/calcium alginate double-network hydrogel beads (CSMAB) were synthesized using an environmentally benign biocomposite material synthesis approach. These CSMAB beads were successfully used for the sequential adsorption of surfactant and removal of methylene blue dye. The beads had a double network hydrogel structure with sodium alginate and chitosan, and acidification of the surface with HCl ensured their reusability for pollutant removal in water. The CSMAB beads were characterized using various techniques, and their adsorption capacity and efficiency for surfactant and dye removal were evaluated.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Oleg Minin, Song Zhou, Cheng-Yang Liu, Jelene Antonicole Ngan Kong, Igor Minin
Summary: This study demonstrates for the first time the induction of intense magnetic concentric subwavelength hot circles in a dielectric mesoscale Janus particle. The magnetic effect of this structure can realize precise magnetic devices for integrated photonic circuits and light-matter interaction.
Article
Chemistry, Applied
Marcella Matos Cordeiro Borges, Bruna Carneiro Pires, Sara Silveira Vieira, Keyller Bastos Borges, Luiz Gustavo de Lima Guimaraes
Summary: A novel magnetic and pH responsive composite hydrogel based on poly(2-(diethylamino)ethyl methacrylate)/chitosan was synthesized and investigated for fipronil removal from aqueous medium. The adsorbent showed high efficiency with an adsorption rate of 80% under optimal conditions of pH 4, 25 mg of adsorbent, and stirring for 60 s. The kinetic and isothermal models provided insights into the adsorption mechanism and demonstrated the potential for removing fipronil from wastewater.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Review
Polymer Science
Karen Guillen-Carvajal, Benjamin Valdez-Salas, Ernesto Beltran-Partida, Jorge Salomon-Carlos, Nelson Cheng
Summary: Hydrogels are versatile biomaterials with three-dimensional, cross-linked, highly hydrated polymeric networks. They have a variety of biochemical and biophysical properties, allowing for diffusion of diverse molecules and control of cellular interactions. Hydrogels can be molded into different structures resembling surrounding tissues and bone defects. Their application in bone tissue engineering has garnered significant attention due to the beneficial bone improvement results achieved. Synthetic polymers have played a key role, but there is a trend towards using biological precursors like chitosan, collagen, and gelatin for their high biocompatibility, degradability, and mechanical control.
Article
Instruments & Instrumentation
C. Czichy, S. Odenbach
Summary: A ink made of alginate and methylcellulose with embedded magnetite microparticles was developed for extrusion printing. A defined magnetic field gradient was applied to achieve non-contact deformation. The deformation behavior and material parameters of the hybrid material were investigated using experiments and micro-computed tomography. The results showed that the material is suitable for mechanical stimulation.
SMART MATERIALS AND STRUCTURES
(2023)
Article
Chemistry, Applied
Reza Eivazzadeh-Keihan, Zeinab Pajoum, Hooman Aghamirza Moghim Aliabadi, Fatemeh Ganjali, Amir Kashtiaray, Milad Salimi Bani, Farnaz Lalebeigi, Elaheh Ziaei Ziabari, Ali Maleki, Majid M. Heravi, Mohammad Mahdavi
Summary: This study successfully prepared a biocompatible magnetic nanobiocomposite with high structural uniformity, thermal stability, biocompatibility, and stability in an aqueous solution. Various analysis methods were used to evaluate the characteristics of the composite material, and the results showed excellent performance in magnetic fluid hyperthermia process.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Roshni D. Hingrajiya, Manish P. Patel
Summary: The present research focuses on the fabrication and characterization of magnetic Fe3O4 incorporated chitosan grafted acrylamide and N-vinylimidazole composite hydrogels (CANFe-1 to CANFe-7). The swelling study showed that CANFe-4 had the highest swelling efficiency, thus it was chosen for the subsequent removal studies. The pH sensitive adsorptive removal of cationic dye (methylene blue) was dominant at pH = 8, with a maximum adsorption capacity of 860 mg/g. The CANFe-4 composite hydrogel can be conveniently separated from the solution using an external magnet, making it a promising adsorbent for wastewater treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Cassiele T. Cesco, Artur J. M. Valente, Alexandre T. Paulino
Summary: Chitosan/DNA blend hydrogel and chitosan/pectin blend hydrogel were synthesized for releasing methylene blue, and characterized by various techniques. The study revealed that the methylene blue loading had different impacts on the hydrogels, with higher release rates observed in simulated gastric fluid. The release kinetics of methylene blue in the hydrogels followed a pseudo-second-order mechanism.
Article
Polymer Science
Chunyan Lei, Qian Xiao, Shanshan Zhou, Weihao Zu, Jialin Li, Jun Zeng, Lulan Yan, Yuewen Huang, Bin Wang
Summary: A new type of magnetic hydrogel adsorbent was successfully synthesized and characterized. The adsorbent showed excellent swelling ratio, adsorption capacity and cyclic performance.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Physical
Jing Guo, Yongjian Wang, Suhong Li, Yanyan Qin, Yaosheng Meng, Lintao Jiang, Hao Huang, Lingdi Shen
Summary: Scalable Janus separators are designed by simply coating and gelating chitosan (CS) on one side of a commercial cotton pad (CP). The zincophilic surface of the CS-CP separator can lock water molecules, buffer protons, and change the transport manner of zinc ions by beneficial adsorption, effectively suppressing dendrite formation and side reactions, and ensuring excellent electrochemical performance.
JOURNAL OF POWER SOURCES
(2023)
Article
Clinical Neurology
Joao Aris Kouyoumdjian, Carla Renata Graca
Summary: The study calculates the reference values for jitter parameters in commonly tested muscles using a disposable concentric needle. It measures the jitter in the Tibialis Anterior muscle, which is not routinely tested, and provides reference ranges for the mean consecutive difference. This study provides guidance for measuring muscle jitter.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lin Zhao, Zhipan Feng, Yang Lyu, Jueying Yang, Lizhi Lin, Haochen Bai, Yujing Li, Yongqiang Feng, Yu Chen
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Automation & Control Systems
Jingxi Wang, Baoyu Liu, Kun Li, Jin Ma, Ping Li
Summary: This study presents the design of an emergency medical assistance robot based on biocompatible magnetic chitosan hydrogels and magnetic actuation. The robot demonstrated precise and controllable deformation behaviors, and was capable of executing tapping motion, biomimetic flight, and thrombus removal through advanced structural design.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Article
Chemistry, Applied
Haichang Ding, Baoqiang Li, Yilin Jiang, Gang Liu, Shouzhi Pu, Yujie Feng, Dechang Jia, Yu Zhou
Summary: The pH-responsive UV-crosslinkable chitosan hydrogel was constructed by selectively modifying C-6-OH chitosan, allowing for active modulation of drug release.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Haichang Ding, Baoqiang Li, Zonglin Liu, Gang Liu, Shouzhi Pu, Yujie Feng, Dechang Jia, Yu Zhou
Summary: A new nonswelling pentenyl chitosan hydrogel was developed via UV crosslinking, which maintains a nonswelling state at biological temperature. The hydrogel showed no cytotoxicity in vitro and demonstrated minimal adverse effects in a rat model. The injectable and UV crosslinkable chitosan hydrogel holds potential applications in smart biomaterials and minimally invasive tissue engineering.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Qing Du, Daqing Wei, Su Cheng, Yaming Wang, Baoqiang Li, Dechang Jia, Yu Zhou
Summary: The formation mechanism of new bone tissues induced by the multilayer titania coating with Si-HA nanorods was revealed through PEO and MG treatments. The coatings showed excellent apatite-inducing ability and high interfacial bonding strength, indicating potential applications in hard tissue and teeth repair.
APPLIED SURFACE SCIENCE
(2021)
Article
Biochemical Research Methods
Baoqiang Li, Jianan Wei, Jinglin Kong, Liu Yang, Cuiping Li
Summary: A new detection method for sulfur mustard hydrolysis products in water was established using MEPS-nano-ESI-MS, with a detection limit of 1 ng/mL and linear range of 5-100 ng/mL (R-2 = 0.9911). The method proved to quickly detect contaminated water samples without chromatographic separation and derivatization, verifying the contamination of sulfur mustard on site.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2021)
Article
Chemistry, Multidisciplinary
Zonglin Liu, Baoqiang Li, Yujie Feng, Dechang Jia, Caicai Li, Qingfeng Sun, Yu Zhou
Summary: The introduction of vacancies in a Ru composite structure with vacancy-rich carbon dots (CDs) leads to the construction of Ru@CDs, which exhibit excellent catalytic performance with a low overpotential of less than 30 mV at 10 mA cm(-2) in 1 m KOH, a small Tafel slope of less than 22 mV decade(-1), and robust stability even after 10,000 cycles. Spectroscopic characterizations and theoretical calculations show that the rich vacancies and electron interactions between Ru and CDs synergistically maximize the activity of the Ru@CDs electrocatalyst.
Article
Chemistry, Physical
Zonglin Liu, Baoqiang Li, Yujie Feng, Dechang Jia, Caicai Li, Qingfeng Sun, Yu Zhou
Summary: In this study, a hybrid material Ni(PO3)(2)/CNTs was designed with excellent HER performance and stability as a non-noble metal electrocatalyst. The pi-pi interaction between NiPc and CNTs, as well as the inlaid structure, effectively prevented corrosion and aggregation of nanoparticles, leading to remarkable HER performance.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Shuang Li, Jingwen Xu, Rui Li, Yongkang Wang, Maoyi Zhang, Jie Li, Shizhen Yin, Guodong Liu, Lijuan Zhang, Baoqiang Li, Qi Gu, Yewang Su
Summary: We present a stretchable electronic facial mask (SEFM) as a platform for facial healthcare, capable of integrating various sensors and actuators. A specific SEFM for sonophoresis is developed to enhance the delivery effect of a drug mask. Various approaches, including the design of a joined silicone layer and the single-side soft pressing (SSSP) technique, are employed to overcome technical challenges and can be extended to the design and fabrication of other stretchable electronics. The mechanical, thermal, electrical, and ultrasonic characteristics of the SEFM are validated through finite element analysis and experiments. Results from animal and human facial experiments demonstrate the SEFM's ability to accelerate drug delivery and increase skin moisture content.
Article
Chemistry, Physical
Zonglin Liu, Baoqiang Li, Yujie Feng, Dechang Jia, Caicai Li, Yu Zhou
Summary: This study successfully improves the activity and stability of carbon-supported ruthenium-based catalysts through the design of a special structure for the carbon carrier. The coexistence of sp(2) and sp(3) carbon nuclei in N-doped carbon dots effectively modulates the electronic structure of the active center Ru, improving the reactivity of the reaction intermediates and achieving excellent catalytic activity.
Article
Chemistry, Physical
Jiaxin Dong, Baoqiang Li, Jin Xiao, Guanxiong Liu, Vladimir Baulin, Yujie Feng, Dechang Jia, Aslan Yu Tsivadze, Yu Zhou
Summary: Carbon dots (CDs) have wide applications in metal ion recognition and detection, promising in environmental monitoring and biomedical science. However, due to the presence of multiple functional groups with different affinities, the prediction of recognized metal ions is limited. In this study, CDs with different chelating ligands were synthesized, and specific recognition of Fe3+ and Cu2+ was achieved. Exponential type functions were established to predict the specific recognition of metal ions. This study proposes a new strategy for specific recognition of heavy metal ions using tailor-made CDs with chelating ligands.
Article
Biochemistry & Molecular Biology
Muqiao Han, Qi Han, Shanwei Wu, Hu Xiao, Lei Zhang, Yibo Lin, Fangang Meng, Shanshan Zhao
Summary: This study investigated the effects of NaOCl dose and solution pH on the properties of PVDF ultrafiltration membranes. The results showed that membrane pores increased with exposure time prolonging, and more pores were observed at pH 8 aging condition. Different chemical groups were formed under different pH conditions. The hydrophilicity and pure water permeability of the membranes had slight changes during NaOCl aging process. The antifouling properties of some membranes were slightly improved, while others showed severer flux decline with humic acid filtration.
Article
Materials Science, Composites
Guanxiong Liu, Baoqiang Li, Zonglin Liu, Jiaxin Dong, Xuefeng Kang, Yujie Feng, Dechang Jia, Yu Zhou
Summary: Carbon dots/hydroxyapatite filler combines the ROS scavenging ability of carbon dots (CDs) and the mechanical property improvement ability of hydroxyapatite. CDs have optical fluorescence, regulate ROS, and have the ability to bind calcium ions. ROS-HA, synthesized by chelating CDs and hydroxyapatite, showed high scavenging rates for hydroxyl and superoxide radicals. It greatly improved the adhesion performance of hydrogel-based composites and has potential applications in wound dressing.
COMPOSITES COMMUNICATIONS
(2023)
Correction
Nanoscience & Nanotechnology
Guanxiong Liu, Baoqiang Li, Jie Li, Jiaxin Dong, Yujie Feng, Dechang Jia, Aslan Yu Tsivadze, Yu Zhou
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Guanxiong Liu, Baoqiang Li, Jie Li, Jiaxin Dong, Vladimir Baulin, Yujie Feng, Dechang Jia, Yuri V. Petrov, Aslan Yu Tsivadze, Yu Zhou
Summary: EGTA-derived carbon dots (EGTA-CDs) exhibit bone-targeting ability with a synthetic yield of 87.6%. EGTA-CDs show superior calcium ion affinity and better bone affinity compared to other derived carbon dots, indicating their potential as novel bone-targeting drugs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Chemical
Yongliang Wang, Yaxin Xu, Yunfei Wang, Baoqiang Li, Chunfeng Wang, Zhidong Han, Ling Weng
Summary: In this study, layered chitosan hydrogel and layered magnetic chitosan hydrogel were successfully constructed by improving the reaction-diffusion process. These tailored hydrogels possessed ordered layered structures and enhanced mechanical properties, especially toughness. The yield strength of magnetic chitosan hydrogel was significantly improved with the addition of magnetite nanoparticles.
Article
Nanoscience & Nanotechnology
Dong Chen, Chaoqun Wang, Hongjun Yu, Guanxiong Liu, Baolin Qian, Bangliang Chen, Zhongyu Li, Yongzhi Zhou, Shangha Pan, Baoqiang Li, Yong Ma
Summary: In this study, chitosan-derived nitrogen-doped carbon dots (CNDs) with reactive oxygen species (ROS) scavenging capabilities were synthesized and applied in the prevention of hepatic ischemia-reperfusion injury (HIRI). CNDs showed scavenging ability against ROS, especially hydroxyl radicals. The results demonstrate that CNDs can alleviate liver damage, suppress the inflammatory response, and inhibit apoptosis triggered by liver ischemia/reperfusion operation.
ACS APPLIED NANO MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
