Article
Engineering, Environmental
Yang Liu, Fanjun Zhang, Linyu Long, Jianguo Li, Zhiyong Liu, Cheng Hu, Xiaoting Chen, Xin Zan, Jianguo Xu, Yunbing Wang
Summary: This study developed an engineered hydrogel system for sequentially targeted drug delivery to treat ischemic stroke. By suppressing inflammation and promoting sustained angiogenesis, the system showed significant therapeutic effects in different stages of the disease.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Food Science & Technology
Leticia Misturini Rodrigues, Mateus Gonzales Domiciano, Edson Araujo de Almeida, Maria Josiane Sereia, Ana Paula Peron, Regiane da Silva
Summary: The microencapsulation process is crucial in the food industry for controlling the release of active ingredients, masking unwanted flavors and smells, increasing shelf life, and protecting components from light, moisture, and nutritional loss. This study successfully developed a bioactive, functional frozen yogurt by incorporating microspheres loaded with ascorbic acid or omega 3. The microspheres formed were small, imperceptible to the palate, and capable of swelling, making them suitable for incorporating omega 3 without altering its properties. The sensory analysis showed that encapsulation was promising in masking the taste and odor of omega 3 and protecting the ascorbic acid while maintaining the quality of the frozen yogurt.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Engineering, Biomedical
Grazia Marsico, Chunseng Jin, Sunny A. Abbah, Eva M. Brauchle, Dilip Thomas, Ana Lucia Rebelo, Doriana Orbanic, Sandrine Chantepie, Paolo Contessotto, Dulce Papy-Garcia, Carlos Rodriguez-Cabello, Michelle Kilcoyne, K. Schenke-Layland, N. G. Karlsson, Karl J. A. McCullagh, Abhay Pandit
Summary: This study demonstrated glycosylation changes associated with ischemia in a murine CLI model, and evaluated the efficacy of an ELR hydrogel for CLI treatment. The ELR hydrogel modulated angiogenic signaling pathways, promoted capillary formation and ECM remodeling, while also inducing arterioles formation, reducing fibrosis, and polarizing anti-inflammatory macrophages. The study suggests a potential role for mannosylation and sialylation in tissue repair, highlighting glycosylation alterations as new therapeutic targets for CLI.
Article
Engineering, Biomedical
Xiongfa Ji, Hongwei Shao, Xiaohong Li, Muhammad Wajid Ullah, Guowen Luo, Ziyang Xu, Limin Ma, Xuecheng He, Zehua Lei, Qian Li, Xulin Jiang, Guang Yang, Yu Zhang
Summary: The inappropriate regeneration of fibrous cartilage and subchondral bone can lead to the failure of cartilage repair. A macrophage-modulated and injectable drug delivery system was developed to promote cartilage and subchondral bone regeneration. This system effectively created a microenvironment that facilitated the regeneration process.
Review
Biotechnology & Applied Microbiology
Honggang Chi, Yunqi Qiu, Xiaoqing Ye, Jielin Shi, Ziyi Li
Summary: This paper reviews the recent progress in the preparation strategy and application of hydrogel microspheres in the field of skin repair. The preparation methods of hydrogel microspheres are summarized, and the related research progress in skin repair is discussed, focusing on bioactive, antibacterial, hemostatic, and delivery platform microspheres. The limitations and future prospects of hydrogel microspheres in skin repair are presented, aiming to provide valuable references for further development and application of hydrogel microspheres.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yan Li, Xin Chen, Ronghua Jin, Lu Chen, Ming Dang, Hao Cao, Yun Dong, Bolei Cai, Guo Bai, J. Justin Gooding, Shiyu Liu, Duohong Zou, Zhiyuan Zhang, Chi Yang
Summary: A microRNA-21-5p delivery system using functionalized mesoporous silica nanoparticles was developed to simultaneously inhibit inflammatory response and promote angiogenesis, effectively reducing infarct size in a porcine model of myocardial infarction.
Review
Pharmacology & Pharmacy
Dongdong Liu, Meng Wei, Wenrui Yan, Hua Xie, Yingbao Sun, Bochuan Yuan, Yiguang Jin
Summary: The incidence of abdominal tumors, such as colorectal and prostate cancers, continues to rise. However, radiation therapy often leads to radiation enteritis (RE) involving the intestine, colon, and rectum, and there is a lack of suitable treatment options for effective prevention and treatment of RE.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Engineering, Biomedical
Oyunchimeg Bayaraa, Khandmaa Dashnyam, Rajendra K. Singh, Nandin Mandakhbayar, Jun Hee Lee, Jong-Tae Park, Jung-Hwan Lee, Hae-Won Kim
Summary: Critical limb ischemia (CLI) is a severe peripheral arterial disease characterized by blocked blood flow, leading to foot necrosis and limb loss. The delivery of cells, such as HUVEC/MSC, with the use of nanoceria-decorated graphene oxide (CeGO) nanosheets enhances cell survival and promotes angiogenic events. This delivery system scavenges excessive ROS, stimulates angiogenesis, and helps in the revascularization and tissue recovery of critical ischemic limbs.
Article
Cell & Tissue Engineering
Chi-Lin Liao, Yang Liu, Meng-Zhao Huang, Hua-Yong Liu, Zi-Liang Ye, Qiang Su
Summary: The study found that curcumin-hydrogel can reduce cardiomyocyte apoptosis, reactive oxygen species formation, promote autophagy, reduce mitochondrial damage, restore cardiac function, inhibit myocardial collagen deposition and apoptosis, and activate the JAK2/STAT3 pathway to alleviate myocardial ischemia-reperfusion injury in rats.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Materials Science, Multidisciplinary
Jingyuan Ji, Chengjin Wang, Zhuo Xiong, Yuan Pang, Wei Sun
Summary: Bone repair is a complex process that involves angiogenesis and osteogenesis, controlled by various factors. This study proposes a 3D-printed scaffold with a sequential delivery platform to promote the coupling regeneration of blood vessels and bones. The scaffold showed enhanced proliferation and differentiation of BMSCs and HUVECs in vitro, and better angiogenesis and osteoinductive effects in vivo.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Hua Liu, Zhengwei Cai, Fei Wang, Liwen Hong, Lianfu Deng, Jie Zhong, Zhengting Wang, Wenguo Cui
Summary: This study developed a colon-targeted adhesive core-shell hydrogel microsphere that regulates the gut immune-microbiota microenvironment, significantly reduces pro-inflammatory cytokine secretion and alleviates colitis in a mouse model, while also optimizing gut flora composition.
Article
Pharmacology & Pharmacy
Lisa Claire du Toit, Yahya Essop Choonara, Viness Pillay
Summary: This study developed an injectable nano-thermogel system for controlled delivery of the p11 anti-angiogenic peptide to prevent neovascularization in ocular disorders. The system showed potential efficacy and biocompatibility through various characterizations and evaluations.
Article
Plant Sciences
Pei Zhang, Suxin You, Xinyue Ding, Pengwei Luan, Jiazhen Xu, Qianfei Cui, Feiyun Wang, Ruixiang Li, Yuying Zhu, Jiange Zhang
Summary: Musk is a widely used traditional Chinese medicine with resuscitation, activating blood, and disperse swelling effects. This study aimed to investigate the effect and mechanism of muscone in improving ischemic stroke, and verified its efficacy in ischemia-reperfused rats, as well as investigated its mechanism using PC12 and THP-1 cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Pilong Shi, Minghui Li, Chao Song, Hanping Qi, Lina Ba, Yonggang Cao, Meitian Zhang, Yawen Xie, Jing Ren, Jiabi Wu, Ping Ren, Hongli Sun
Summary: Cardiac microvascular dysfunction is associated with cardiac hypertrophy and heart failure. Dysregulation of long non-coding RNAs (lncRNAs) plays a key role in cardiac hypertrophy. This study identified a lncRNA, AAB, that is upregulated in cardiac hypertrophy rats and in Ang II-induced cardiac microvascular endothelial cells (CMECs). LncRNA AAB sponges miR-30b-5p, leading to an imbalance of MMP9/TIMP1 and activation of transferrin receptor 1 (TFR-1), which ultimately leads to ferroptosis of CMECs. Additionally, a delivery system based on neutrophil membrane-camouflaged mesoporous silica nanocomplex (MSN) was developed for the inhibition of cardiac hypertrophy, indicating the potential of targeting lncRNA AAB as a novel therapy for cardiac hypertrophy.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Engineering, Biomedical
Zheng Xing, Chen Zhao, Siwen Wu, Chunchen Zhang, Haifeng Liu, Yubo Fan
Summary: Therapeutic angiogenesis provides a potential solution for critical limb ischemia by manipulating blood vessel growth in vivo without the need for extra pharmaceutics and surgery. With the rise of interdisciplinary research, regenerative medicine strategies offer new possibilities for treating various clinical diseases.
Article
Biochemistry & Molecular Biology
Sang Woo Kim, Do Yoon Kim, Hyun Ho Roh, Hyun Seung Kim, Jae Won Lee, Kuen Yong Lee
Article
Chemistry, Applied
Yerang Seo, Hyunji Lee, Jae Won Lee, Kuen Yong Lee
CARBOHYDRATE POLYMERS
(2019)
Article
Chemistry, Applied
Chunggoo Kim, Hwi Kim, Honghyun Park, Kuen Yong Lee
CARBOHYDRATE POLYMERS
(2019)
Article
Chemistry, Multidisciplinary
Hyun Ji Lee, Yerang Seo, Hyun Seung Kim, Jae Won Lee, Kuen Yong Lee
Article
Biochemistry & Molecular Biology
Hyun-Ho Roh, Hyun-Seung Kim, Chunggoo Kim, Kuen-Yong Lee
Summary: Three-dimensional bioprinting technology has been utilized for tissue and organ regeneration, especially with the self-healing properties of hydrogels composed of oxidized hyaluronate, glycol chitosan, and adipic acid dihydrazide. The addition of alginate in the hydrogels enhances their structural stability while maintaining self-healing capability, making them suitable for various tissue engineering applications. The potential application of these hydrogels in cartilage regeneration through 3D bioprinting has also been investigated.
Article
Biophysics
Youngtae Choi, Choonggu Kim, Hyun Seung Kim, Changwook Moon, Kuen Yong Lee
Summary: Hydrogels are commonly used in tissue engineering for creating functional synthetic extracellular matrices. By combining self-healing hydrogel and self-healing ferrogel, a dynamic tissue scaffold can be fabricated without post-cross-linking, allowing for regulation of cell phenotype under magnetic stimulation. This approach shows potential for 3D printing dynamic tissue scaffolds for tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Polymer Science
Eun-Ju Jeong, Jangwook Lee, Hyun-Seung Kim, Kuen-Yong Lee
Summary: The introduction of oligoarginine peptide to glycol chitosan improved its solubility and resulted in enhanced transfection efficiency in vitro while maintaining low cytotoxicity. The oligoarginine-modified glycol chitosan may serve as a potential gene carrier in therapeutic applications.
Article
Biophysics
Chang Uk Mun, Hyun Seung Kim, Minhyung Kong, Kuen Yong Lee
Summary: This study successfully developed a 3D printable and stretchable ferrogel using hyaluronic acid derivatives and superparamagnetic iron oxide nanoparticles. The ferrogel exhibited self-healing properties, improved stretchability, and the ability to fabricate complex structures through extrusion-based printing. These magnetic field-responsive and 3D printable hydrogel systems hold great potential for tissue engineering applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Young Kyoung Han, Eun Ju Jeong, Yerang Seo, In Young Lee, Suim Choi, Hyewon Lee, Choonggu Kim, Taiyoun Rhim, Kuen Yong Lee
Summary: A strategy to selectively reduce subcutaneous fat using polymer nanoparticles is reported. The nanoparticles generate carbon dioxide gas within adipocytes, inducing adipocytolysis and reducing the number of cells. In a mouse model, localized injection of the nanoparticles significantly reduces subcutaneous fat without affecting hematological or serum biochemical parameters. This strategy addresses the need for safe and effective adipocytolytic agents.
Article
Chemistry, Multidisciplinary
Jangwook Lee, Kwangmeyung Kim, Ick Chan Kwon, Kuen Yong Lee
Summary: A new anticancer strategy exploiting abnormal cancer cell metabolism is reported. An antiglycolytic amphiphilic polymer is synthesized and regulates glucose metabolism to inhibit tumor growth. This strategy highlights the necessity for safe and effective cancer treatment without conventional drugs.
ADVANCED MATERIALS
(2023)
Article
Medicine, Research & Experimental
Irfan Ullah, Kunho Chung, Sumin Bae, Yan Li, Chunggu Kim, Boyoung Choi, Hye Yeong Nam, Sun Hwa Kim, Chae-Ok Yun, Kuen Yong Lee, Priti Kumar, Sang-Kyung Lee
MOLECULAR PHARMACEUTICS
(2020)
Article
Biophysics
Jae Won Lee, Hyoseok An, Kuen Yong Lee
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)
Article
Biophysics
Jae Won Lee, Kuen Yong Lee
COLLOIDS AND SURFACES B-BIOINTERFACES
(2017)
Article
Chemistry, Applied
Honghyun Park, Hyun Ji Lee, Hyoseok An, Kuen Yong Lee
CARBOHYDRATE POLYMERS
(2017)
Article
Chemistry, Applied
Do Yoon Kim, Honghyun Park, Sang Woo Kim, Jae Won Lee, Kuen Yong Lee
CARBOHYDRATE POLYMERS
(2017)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)