Article
Chemistry, Multidisciplinary
Zikuan Gu, Yueru Dong, Shuxin Xu, Lisheng Wang, Zhen Liu
Summary: This study presents a smart prodrug delivery system based on molecularly imprinted polymers (MIPs) for specific accumulation and gradual release of drugs at tumor sites. In contrast to traditional prodrug designs, this system is liver-independent and relies on tumor environments for drug release.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
A. De Capua, A. Palladino, M. Chino, C. Attanasio, A. Lombardi, R. Vecchione, P. A. Netti
Summary: The study focuses on the selectivity in tumor targeting by implementing CD44 binding peptide logic onto an oil core-polymer multilayer shell, enabling the selective delivery of therapeutic compounds to cancer cells. The system demonstrates small size, drug loading capability, and active targeting properties, facilitating the accumulation and internalization of nanocapsules in cancer cells through ligand-receptor binding.
Article
Chemistry, Multidisciplinary
Roman A. Barmin, Mirjavad Moosavifar, Anshuman Dasgupta, Andreas Herrmann, Fabian Kiessling, Roger M. Pallares, Twan Lammers
Summary: Ultrasound (US) is widely used for diagnostic imaging and treatment, and polymeric materials with cavitation nuclei properties can enhance US imaging and promote local drug delivery. This review discusses engineered polymeric materials, such as microbubbles and gas-releasing nanoparticles, that respond to US and their formulation aspects. It focuses on microbubbles and explores the chemical toolbox to enhance their performance in US imaging and drug delivery. The review also summarizes the emerging applications of polymeric microbubbles in molecular imaging, sonopermeation, and gas and drug delivery, highlighting their potential in US imaging and therapy.
Review
Chemistry, Multidisciplinary
Palmira Alessia Cavallaro, Marzia De Santo, Emilia Lucia Belsito, Camilla Longobucco, Manuela Curcio, Catia Morelli, Luigi Pasqua, Antonella Leggio
Summary: Breast cancer is a common and deadly disease, and overexpression of HER2 is a major contributing factor. This review provides an overview of the diagnosis and treatment approaches for HER2-positive breast cancer in the past decade. Antibodies and peptides are explored as targeting strategies, with nanotechnology offering potential solutions to current clinical challenges in breast cancer imaging, targeting, and therapy.
Article
Multidisciplinary Sciences
Shima Shahrad, Mohammad Rajabi, Hamidreza Javadi, Ali Akbar Karimi Zarchi, Mohammad Hasan Darvishi
Summary: MUC1 aptamer-functionalized PLA-PEG nanocarriers were prepared at various w/w ratios and evaluated for their physiochemical properties, drug release kinetics, cytotoxicity, and antitumor activity. Targeted nanocarriers at a w/w ratio of 10:1 demonstrated significantly higher apoptosis rates in MUC1-overexpressing cancer cells compared to non-targeted and free drug forms, suggesting their potential as a promising drug delivery system for targeted therapy.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Benjamin R. Kingston, Zachary P. Lin, Ben Ouyang, Presley MacMillan, Jessica Ngai, Abdullah Muhammad Syed, Shrey Sindhwani, Warren C. W. Chan
Summary: A subset of tumor endothelial cells, named N-TECs, has been discovered to facilitate the transport of nanoparticles into solid tumors. Only 21% of tumor endothelial cells are involved in this process, with N-TECs showing increased expression of genes related to nanoparticle transport and vessel permeability compared to other cells. N-TECs act as gatekeepers determining the entry point, distribution, cell accessibility, and number of nanoparticles entering the tumor microenvironment.
Article
Chemistry, Analytical
Runrun Li, Thea A. Vedelaar, Alina Sigaeva, Yue Zhang, Kaiqi Wu, Hui Wang, Xixi Wu, Peter Olinga, Malgorzata K. Wlodarzyk-Biegun, Romana Schirhagl
Summary: Polymer nanoparticles are widely used in drug delivery and cause potential concerns regarding the increase in nano- or microplastics in the environment. To understand their mechanism of action and ensure safe usage, it is important to know their localization within cells and tissues. We labeled polymer nanoparticles with nanodiamond particles, allowing long-term imaging and tracking, and demonstrated this principle in both cells and liver tissues.
ANALYTICAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Yi-Xuan Li, Hong-Bo Wang, Jing Li, Jian-Bo Jin, Jing-Bo Hu, Chun-Lin Yang
Summary: Pulmonary vascular endothelial cells play a crucial role in respiratory diseases, and targeting them through drug delivery systems can effectively treat these diseases. The unique structure and blood perfusion rate of pulmonary vessels promote drug distribution in lung tissues.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Zhengjie Meng, Hao Wang, Xue Fang, Zhangya Liu, Zheng Yang, Jiahui Yong, Qingqing Yang, Yunhao Bai, Hao Ren, Hao Xu, Xueming Li
Summary: The study demonstrated that utilizing P-selectin as a target for drug nanocrystals to tumors can enhance drug accumulation and anti-tumor efficacy, while maintaining a good safety profile for cancer treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Paul J. Weldick, Anheng Wang, Ahmed F. Halbus, Vesselin N. Paunov
Summary: Antimicrobial resistance is a major global cause of mortality due to the overuse of common antibiotics and antifungals. Resistance is being developed to the currently available drugs, creating challenges in antimicrobial treatment. Nanoparticle-based technologies, combining novel nanomaterial research and classic therapies, show promise in overcoming antimicrobial resistance.
Review
Chemistry, Multidisciplinary
Behnaz Lahooti, Racheal G. Akwii, Fatema Tuz Zahra, Md Sanaullah Sajib, Margarita Lamprou, Ahmed Alobaida, Michail S. Lionakis, George Mattheolabakis, Constantinos M. Mikelis
Summary: The review focuses on the characteristics and regulation of vascular permeability in tumor microenvironment, especially the impact of endothelial cells. It discusses the challenges and approaches of targeting vascular permeability for clinical translation, the effects of immune cells on the tumor vessels and nanomedicine delivery, and desirable nanoparticle design approaches.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Materials Science, Multidisciplinary
Abdullah Abdelkawi, Aliyah Slim, Zaineb Zinoune, Yashwant Pathak
Summary: This review focuses on the surface modification of metallic nanoparticles for targeted drug delivery. Various strategies, such as polymer coating, functionalization with specific groups, and bioconjugation with targeting ligands, have been explored to enhance their therapeutic potential. The challenges in clinical translation include scalable fabrication and functionalization of nanoparticles, toxicity concerns, and regulatory hurdles. However, continuous advancements in nanoparticle synthesis and surface modification techniques offer a positive outlook for the future.
Review
Oncology
Zhi Wei Tay, Prashant Chandrasekharan, Benjamin D. Fellows, Irati Rodrigo Arrizabalaga, Elaine Yu, Malini Olivo, Steven M. Conolly
Summary: Magnetic Particle Imaging (MPI) is an emerging imaging technique that provides direct imaging of superparamagnetic iron oxide nanoparticles, showing great potential in cancer diagnosis and therapy monitoring. Different from MRI, MPI offers ideal image contrast with zero background tissue signal, enabling clear visualization of cancer. MPI enhances therapeutic precision and accuracy through magnetic means, contributing to the advancement of cancer imaging and guided therapy.
Article
Oncology
Sibi Raj, Sartaj Khurana, Ramesh Choudhari, Kavindra Kumar Kesari, Mohammad Amjad Kamal, Neha Garg, Janne Ruokolainen, Bhudev C. Das, Dhruv Kumar
Summary: Nanotechnology offers a promising approach for cancer diagnosis and treatment, providing specific and efficient drug delivery to target tissues while minimizing side effects. Various types of nanocarriers are being studied for potential use in cancer therapy.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Yajing Sun, Qingshan Yang, Xue Xia, Xiaozhe Li, Weimin Ruan, Meng Zheng, Yan Zou, Bingyang Shi
Summary: Researchers are focusing on developing polymeric nanoparticles targeted at mitochondria to enhance the efficiency of cancer therapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Emile Jubeli, Amanda B. Maginty, Nada Abdul Khalique, Liji Raju, David G. Nicholson, Helge Larsen, Michael D. Pungente, William P. D. Goldring
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Polymer Science
Micheal Nouman, Johanna Saunier, Emile Jubeli, Christian Marliere, Najet Yagoubi
EUROPEAN POLYMER JOURNAL
(2017)
Article
Engineering, Biomedical
Melisande Bernard, Emile Jubeli, Joudi Bakar, Lionel Tortolano, Johanna Saunier, Najet Yagoubi
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Review
Chemistry, Multidisciplinary
Felix Sauvage, Samir Messaoudi, Elias Fattal, Gillian Barratt, Juliette Vergnaud-Gauduchon
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Materials Science, Biomaterials
H. Al Salloum, J. Saunier, A. Dazzi, J. Vigneron, A. Etcheberry, C. Marliere, C. Aymes-Chodur, J. M. Herry, M. Bernard, E. Jubeli, N. Yagoubi
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Article
Polymer Science
Micheal Nouman, Johanna Saunier, Emile Jubeli, Najet Yagoubi
POLYMER DEGRADATION AND STABILITY
(2017)
Article
Oncology
Felix Sauvage, Elias Fattal, Walhan Al-Shaer, Stephanie Denis, Emilie Brotin, Christophe Denoyelle, Cecile Blanc-Fournier, Balthazar Toussaint, Samir Messaoudi, Mouad Alami, Gillian Barratt, Juliette Vergnaud-Gauduchon
Article
Biophysics
Lionel Tortolano, Johanna Saunier, Senda Hammami, Katia Manerlax, Houssem Matmati, Bernard Do, Emile Jubeli, Elias Fattal, Najet Yagoubi
COLLOIDS AND SURFACES B-BIOINTERFACES
(2018)
Article
Chemistry, Multidisciplinary
Walhan Alshaer, Herve Hillaireau, Juliette Vergnaud, Simona Mura, Claudine Delomenie, Felix Sauvage, Said Ismail, Elias Fattal
JOURNAL OF CONTROLLED RELEASE
(2018)
Review
Materials Science, Biomaterials
Melisande Bernard, Emile Jubeli, Michael D. Pungente, Najet Yagoubi
BIOMATERIALS SCIENCE
(2018)
Article
Materials Science, Biomaterials
Emile Jubeli, Afif Khzam, Najet Yagoubi
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2019)
Article
Materials Science, Biomaterials
Melisande Bernard, Emile Jubeli, Joudi Bakar, Johanna Saunier, Najet Yagoubi
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Chemistry, Multidisciplinary
Gana Amokrane, Vincent Humblot, Emile Jubeli, Najet Yagoubi, Salah Ramtani, Veronique Migonney, Celine Falentin-Daudre
Article
Chemistry, Multidisciplinary
Federica Costamagna, Herve Hillaireau, Juliette Vergnaud, Damien Clarisse, Lucie Jamgotchian, Olivier Loreau, Stephanie Denis, Edmond Gravel, Eric Doris, Elias Fattal
Article
Nanoscience & Nanotechnology
Marine Le Goas, Aurelie Paquirissamy, Dorra Gargouri, Giulia Fadda, Fabienne Testard, Caroline Aymes-Chodur, Emile Jubeli, Thierry Pourcher, Beatrice Cambien, Serge Palacin, Jean-Philippe Renault, Geraldine Carrot
ACS APPLIED BIO MATERIALS
(2019)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)