Article
Chemistry, Multidisciplinary
Lukas Christian Sebeke, Juan Daniel Castillo Gomez, Edwin Heijman, Pia Rademann, Alexandra Claudia Simon, Sandra Ekdawi, Susan Vlachakis, Dennis Toker, Ben Lasse Mink, Claudia Schubert-Quecke, Sin Yuin Yeo, Patrick Schmidt, Christina Lucas, Susanne Brodesser, Martin Hossann, Lars H. Lindner, Holger Gruell
Summary: In this article, the localized release of doxorubicin (DOX) from thermosensitive liposomes was achieved using MR-HIFU mediated hyperthermia in a swine model. The study showed a significant increase in DOX concentration in the muscle tissue after hyperthermia treatment, and there was a correlation between the pharmacokinetics of DOX in the bloodstream and its accumulation in the target tissue.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Maryam Chaudhry, Paul Lyon, Constantin Coussios, Robert Carlisle
Summary: This article evaluates the progress of thermolabile drug carrier systems in pre-clinical and clinical settings, as well as the modalities used to trigger drug release. The combined application of mild hyperthermia and heat-responsive liposomal drug carriers shows great potential utility, and ongoing clinical trials aim to refine this approach for optimal patient benefit.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Review
Oncology
Dieter Haemmerich, Krishna K. Ramajayam, Danforth A. Newton
Summary: Various nanoparticles, such as thermosensitive liposomes (TSL), have been developed for targeted drug delivery to cancerous tumors by releasing the drug in response to hyperthermia. TSL can achieve superior tumor drug uptake compared to traditional drug delivery systems. This review discusses the delivery kinetics of TSL and provides guidelines on how to improve drug delivery by optimizing the combination of TSL, drug, and hyperthermia method.
Article
Biophysics
L. Somaglino, L. Mousnier, A. Giron, W. Urbach, N. Tsapis, N. Taulier
Summary: Polymeric nanoparticles are being studied as potential drug carriers, and their drug release can be enhanced by triggering with ultrasound. However, the release is only significantly increased in the presence of detectable inertial cavitation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Yu-Jen Lu, Hao-Lung Hsu, Yu-Hsiang Lan, Jyh-Ping Chen
Summary: Thermosensitive cationic magnetic liposomes (TCMLs) were prepared for controlled drug/gene release in cancer treatment. The liposomes were made from DPPC, cholesterol, PEGylated lipid, and DDAB, and co-entrapped MNPs and CPT-11. The drug release was triggered by temperature increase or magneto-heating, and the liposomes showed enhanced cytotoxicity and gene silencing effect in glioblastoma cells.
Article
Chemistry, Multidisciplinary
Chia-Chen Yu, Aastha Shah, Nikta Amiri, Colin Marcus, Md Osman Goni Nayeem, Amit Kumar Bhayadia, Amin Karami, Canan Dagdeviren
Summary: Researchers report a soft ultrasound patch that enhances transdermal transport of niacinamide by inducing intermediate-frequency sonophoresis. The patch consists of piezoelectric transducers embedded in a soft elastomer to create localized cavitation pockets over larger areas of conformal contact. The system demonstrates a 26.2-fold enhancement in niacinamide transport in a porcine model in vitro, showing its suitability for short-exposure, large-area application of sonophoresis for patients and consumers suffering from skin conditions and premature skin aging.
ADVANCED MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Mah Noor Zafar, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: In order to improve current cancer treatments, nanomaterials are used as smart drug delivery vehicles that can be designed to specifically target cancer cells and respond to stimulation. These nanocarriers can encapsulate chemotherapy drugs and deliver them to the affected area, reducing the side effects associated with conventional systemic administration. Different sonosensitive liposomal formulations that can be stimulated using acoustic methods are discussed in this review. Emulsion liposomes (eLiposomes) are highlighted for their ability to promote drug release at low intensities and short exposure times compared to regular liposomes. Other formulations incorporating microbubbles and nanobubbles are also explored.
Article
Nanoscience & Nanotechnology
Maximilian Regenold, Pauric Bannigan, James C. Evans, Adam Waspe, Michael J. Temple, Christine Allen
Summary: A single disappointing study does not mean the end for ThermoDox, which still has potential to be an effective cancer treatment. Despite challenges faced, heat-triggered drug delivery platforms still hold tremendous potential for development.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Brian Lyons, Joel P. R. Balkaran, Darcy Dunn-Lawless, Veronica Lucian, Sara B. Keller, Colm S. O'Reilly, Luna Hu, Jeffrey Rubasingham, Malavika Nair, Robert Carlisle, Eleanor Stride, Michael Gray, Constantin Coussios, Yi Lu, Zhongjian Chen
Summary: Ultrasound-mediated cavitation shows great potential for targeted drug delivery. Cavitation nuclei, as sound-sensitive structures enhancing cavitation activity, have become effective adjuvants in ultrasound-based treatments and have emerged as drug delivery vehicles. The unique combination of physical, biological, and chemical effects, as well as the diverse compositions and morphologies, make cavitation nuclei an attractive platform for creating delivery systems.
Article
Instruments & Instrumentation
Maximilian Regenold, Xuehan Wang, Kan Kaneko, Pauric Bannigan, Christine Allen
Summary: Chemotherapy plays a significant role in shrinking tumors, treating residual diseases, and addressing metastatic diseases. Advanced drug delivery strategies, such as thermosensitive liposome-mediated drug delivery, have emerged to offer more targeted approaches. However, the risk of overlooking metastatic spread remains. This study explores the combination of thermosensitive liposomes, localized mild hyperthermia, and immune checkpoint inhibition therapy to enhance systemic treatment capabilities.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Acoustics
Xiaoxiao Zhao, Alex Wright, David E. Goertz
Summary: Therapeutic focused ultrasound combined with encapsulated microbubbles have the ability to induce different bioeffects in the microvasculature. This study examines how the behavior and emissions of microbubbles change with different channel diameters and pressures. The results provide new insights into microbubble behavior in small vessels at higher pressures.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Matteo Petrini, Wouter J. M. Lokerse, Agnieszka Mach, Martin Hossann, Olivia M. Merkel, Lars H. Lindner
Summary: The study demonstrates the potential of positively charged nanocarriers in targeting tumor-angiogenic endothelial cells. The absence of PEG in cationic TSLs promoted more efficient liposome-cell interactions and drug delivery. Dual-targeted cationic TSLs showed selective drug release in the intracellular compartment under hyperthermia, with optimal drug delivery demonstrated by DPPG(2)-based anionic TSL.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemical Research Methods
Tri Vu, Yuqi Tang, Mucong Li, Georgii Sankin, Shanshan Tang, Shigao Chen, Pei Zhong, Junjie Yao
Summary: The study developed an integrated HIFU-PACT system for detecting vascular rupture in mechanical HIFU treatment. They demonstrated the use of singular value decomposition to enhance hemorrhage detection and validated the system's performance on phantoms and in vivo animal tumor models. This PACT-HIFU system is expected to have practical applications in oncology research using small animal models.
BIOMEDICAL OPTICS EXPRESS
(2021)
Article
Oncology
Laura Spiers, Michael Gray, Paul Lyon, Shivan Sivakumar, Noor Bekkali, Shaun Scott, Linda Collins, Robert Carlisle, Feng Wu, Mark Middleton, Constantin Coussios
Summary: This study aims to enhance drug delivery to patients with pancreatic ductal adenocarcinomas by using ultrasound-mediated hyperthermia.
Review
Pharmacology & Pharmacy
Rachel Chapla, Katherine T. Huynh, Carolyn E. Schutt
Summary: Targeted delivery of therapeutics is crucial for reducing systemic toxicity and optimizing therapeutic efficacy. Ultrasound-controlled targeting is an externally-stimulated drug delivery strategy, using ultrasound waves to stimulate gas-filled microbubbles and deliver attached cargo to surrounding cells. The attachment of nanocarrier particles to microbubbles greatly enhances drug delivery capabilities.
Article
Radiology, Nuclear Medicine & Medical Imaging
Cyril J. Ferrer, Lambertus W. Bartels, Fiji A. van der Velden, Holger Gruell, Edwin Heijman, Chrit T. W. Moonen, Clemens Bos
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Oncology
Arina Riabinska, Daria Lehrman, Ron Daniel Jachimowicz, Gero Knitter, Christian Fritz, Anna Schmitt, Aenne Geyer, Carola Heneweer, Maike Wittersheim, Lukas P. Frenzel, Alessandro Torgovnick, Janica Lea Wiederstein, Claudia Maria Wunderlich, Monika Ortmann, Arlette Paillard, Wilhelm Woessmann, Arndt Borkhardt, Stefan Burdach, Martin-Leo Hansmann, Andreas Rosenwald, Sven Perner, Gita Mall, Wolfram Klapper, Andrea Merseburg, Marcus Krueger, Holger Gruell, Thorsten Persigehl, Frank Thomas Wunderlich, Martin Peifer, Olaf Utermoehlen, Reinhard Buettner, Filippo Beleggia, Hans Christian Reinhardt
Correction
Pharmacology & Pharmacy
Maike Trommer, Sin Yuin Yeo, Thorsten Persigehl, Anne Bunck, Holger Gruell, Max Schlaak, Sebastian Theurich, Michael von Bergwelt-Baildon, Janis Morgenthaler, Jan M. Herter, Eren Celik, Simone Marnitz, Christian Baues
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Automation & Control Systems
Daniel A. Deenen, Bert Maljaars, Lukas C. Sebeke, Bram de Jager, Edwin Heijman, Holger Grull, W. P. Maurice H. Heemels
Summary: Hyperthermia therapy is valuable in cancer treatment. A model predictive control setup is developed to improve temperature regulation in MR-HIFU treatments, effectively addressing plant-model mismatch and modeling errors in practice. In vivo experiments on porcine thigh muscle demonstrate the controller's performance.
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
(2021)
Article
Oncology
Julia Simoes Correa Galendi, Sin Yuin Yeo, Dusan Simic, Holger Gruell, Stephanie Stock, Dirk Mueller
Summary: This study conducted a TD-ABC analysis to determine the resource consumption and total costs of MR-HIFU treatment for cancer-induced bone pain. The results showed that the total cost per patient was euro5147, indicating that MR-HIFU can be considered a first-line treatment for CIBP and can support reimbursement negotiations.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Immunology
Anja Meyer, Shuaifeng Yan, Viktoria Golumba-Nagy, Ruth L. Esser, Verena Barbarino, Stuart J. Blakemore, Lisa Rusyn, Anastasia Nikiforov, Tamina Seeger-Nukpezah, Holger Gruell, Christian P. Pallasch, David M. Kofler
Summary: The study found significantly altered post-translational phosphorylation of kinase related proteins, including GPSM2, PTK6, and VTNC, in CD4+ T cells from rheumatoid arthritis (RA) patients, with GPSM2 being revealed to promote Treg cell migration in healthy individuals. Treatment with interleukin-6 receptor blocking antibodies can restore GPSM2 expression and improve Treg cell migration in RA patients. This highlights the potential of multiplex kinase activity arrays for identifying RA-related proteins as potential targets for novel treatments.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Chemistry, Multidisciplinary
Lukas Christian Sebeke, Juan Daniel Castillo Gomez, Edwin Heijman, Pia Rademann, Alexandra Claudia Simon, Sandra Ekdawi, Susan Vlachakis, Dennis Toker, Ben Lasse Mink, Claudia Schubert-Quecke, Sin Yuin Yeo, Patrick Schmidt, Christina Lucas, Susanne Brodesser, Martin Hossann, Lars H. Lindner, Holger Gruell
Summary: In this article, the localized release of doxorubicin (DOX) from thermosensitive liposomes was achieved using MR-HIFU mediated hyperthermia in a swine model. The study showed a significant increase in DOX concentration in the muscle tissue after hyperthermia treatment, and there was a correlation between the pharmacokinetics of DOX in the bloodstream and its accumulation in the target tissue.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Environmental Sciences
Julia Simoes Correa Galendi, Ann-Cathrine Siefen, Debora M. M. Moretti, Sin Yuin Yeo, Holger Gruell, Grischa Bratke, Alessio Giuseppe Morganti, Alberto Bazzocchi, Chiara Gasperini, Francesca De Felice, Roberto Blanco Sequeiros, Mira Huhtala, Ingrid M. M. Nijholt, Martijn F. F. Boomsma, Clemens Bos, Helena M. M. Verkooijen, Dirk Mueller, Stephanie Stock
Summary: Magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) is an innovative treatment for painful bone metastases. However, its adoption is influenced by various factors, and addressing these factors from different clusters is crucial for its widespread use.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Oncology
Sin Yuin Yeo, Grischa Bratke, Holger Gruell
Summary: High Intensity Focused Ultrasound (HIFU) is a non-invasive method for ablating tumors and treating painful bone lesions. It has been used for pain relief in bone metastases and primary tumors for 20 years, as well as for local treatment of bone tumors. This review summarizes 20 years of literature on HIFU treatment of bone malignancies, focusing on pain palliation, treatment efficacy, and safety.
Article
Oncology
Sven Nouwens, Maarten Paulides, Johannes Lindemeyer, Lukas Sebeke, Ricky van Kampen, Holger Gruell, Maurice Heemels
Summary: This study proposes a new frequency-domain estimation method for quality assurance in thermal therapy, which can provide unbiased estimates of specific absorption rate (SAR) and thermal diffusivity. By periodically modulating the power of focused ultrasound and recording the response with MRI thermometry, spatial Fourier coefficients are used to estimate the thermal response and parameters. The experimental results show that this method has a high signal-to-noise ratio (SNR) and reproducible estimates, with insensitivity to B 0 drift and non-steady-state initial temperature distributions.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2023)
Proceedings Paper
Automation & Control Systems
D. A. Deenen, E. Maljaars, L. Sebeke, B. de Jager, E. Heijman, H. Gruell, W. P. M. H. Heemels
Article
Oncology
Lukas Christian Sebeke, Pia Rademann, Alexandra Claudia Maul, Claudia Schubert-Quecke, Thorsten Annecke, Sin Yuin Yeo, Juan Daniel Castillo-Gomez, Patrick Schmidt, Holger Grull, Edwin Heijman
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2020)
Article
Oncology
Lukas Christian Sebeke, Pia Rademann, Alexandra Claudia Maul, Sin Yuin Yeo, Juan Daniel Castillo Gomez, Daniel A. Deenen, Patrick Schmidt, Bram de Jager, W. P. M. H. Heemels, Holger Gruell, Edwin Heijman
Summary: This study reports the in-vivo application of a model-predictive control algorithm for MR-HIFU hyperthermia and investigates its performance in the presence of heterogeneous perfusion. Results show that the MPC algorithm performed well, allocating heating power based on the blood vessel distribution visible on contrast-enhanced MRI images. The rapid thermometry feedback and flexible power allocation allowed for temperature distributions with a narrow spectrum inside the target ROI despite the spatiotemporal heterogeneity in perfusion.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Review
Oncology
H. Petra Kok, Erik N. K. Cressman, Wim Ceelen, Christopher L. Brace, Robert Ivkov, Holger Gruell, Gail ter Haar, Peter Wust, Johannes Crezee
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2020)
Article
Oncology
L. Sebeke, D. A. Deenen, E. Maljaars, E. Heijman, B. de Jager, W. P. M. H. Heemels, H. Gruell
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2019)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)