Review
Food Science & Technology
Victoria Nahum, Abraham J. Domb
Summary: The health food industry has significantly influenced the market, prompting food industries to focus on utilizing bioactive compounds. However, the sensitive and lipophilic nature of these compounds presents challenges in terms of stability and bioavailability. Researchers have turned to solid lipid-based carriers, such as solid lipid particles, to improve the delivery and effectiveness of these bioactive compounds in food matrices.
Article
Biochemical Research Methods
Peer Erfle, Juliane Riewe, Heike Bunjes, Andreas Dietzel
Summary: The coaxial lamination mixer (CLM) enables efficient production of stable, scalable lipid nanoparticles loaded with poorly soluble drugs, ensuring high throughput parallelization.
Article
Chemistry, Multidisciplinary
Sohyung Lee, Joseph de Rutte, Robert Dimatteo, Doyeon Koo, Dino Di Carlo
Summary: Researchers have developed a scalable method for manufacturing hydrogel microparticles with defined shapes and chemical functionalization. The process involves using a two-phase system and microfluidic technology, and allows for localized surface chemistry on the microparticles. These microparticles can be used for cell loading and single-cell secretion analysis.
Article
Pharmacology & Pharmacy
Eliza Wolska, Marta Brach
Summary: The distribution of drug substances in solid lipid microparticles (SLM) was studied in order to distinguish the localization of drugs in the lipid matrix and on the surface of the microspheres. The traditional characterization methods based on entrapment efficiency (EE) and drug loading (DL) parameters were found to be insufficient. A new distribution test method was proposed to demonstrate the localization of drugs within the microspheres. This research provides new opportunities for the development and use of SLM as a carrier for prolonged drug release and other advantages.
Article
Mechanics
Desiree Ruiz-Martin, Javier Rivero-Rodriguez, Mario Sanchez-Sanz
Summary: This work focuses on the dynamics of solid particles flowing near a deformable interface formed by two co-flowing immiscible fluids in a microchannel. The study systematically analyzes the influence of various parameters on the hydrodynamic force exerted on the particles. The analysis includes both the pure inertial regime and the pure capillary regime, revealing the interaction mechanisms between the particles and the interface.
JOURNAL OF FLUID MECHANICS
(2022)
Review
Chemistry, Multidisciplinary
Lijun Cai, Feika Bian, Hanxu Chen, Jiahui Guo, Yongan Wang, Yuanjin Zhao
Summary: Anisotropic microparticles have attracted significant scientific interest due to their unique morphology, composition, and multifunctionality. Microfluidic techniques enable precise flow control for producing anisotropic microparticles with excellent mono-dispersity and uniformity. This review provides an overview of anisotropic microparticles from microfluidics, covering fabrication approaches, applications, and future development prospects.
Article
Pharmacology & Pharmacy
Leon Yoon Ho, Zi Shun Xiang, Renuga Gopal, Saif A. Khan
Summary: This paper demonstrates a microfluidics-enabled process for engineering monodisperse solid lipid microparticles with uniform drug loading and particle size, making it applicable to various drugs and lipid formulations. The method utilizes a volatile solvent and microfluidic flow extrusion to achieve high precision in particle size and drug loading, enhancing monodispersity and enabling the formulation of SLMs with diverse solid-state outcomes for different drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Instruments & Instrumentation
Edward Weaver, Federica Sommonte, Andrew Hooker, Nunzio Denora, Shahid Uddin, Dimitrios A. Lamprou
Summary: A novel in-house method of microfluidic production of biologic-encapsulated SLNs is proposed, which allows for high encapsulation efficiencies of both large hydrophilic and small hydrophobic active pharmaceutical ingredients. The study provides useful insight into sustained kinetics through in vitro analysis, which is valuable for future in vivo studies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Polymer Science
Jiwoo Bae, Hye Min Seo, Kyounghee Shin, Jihyun Choi, Dong Ryeol Lee, Zhiting Jiang, Di Shen, Jin Woong Kim
Summary: This study introduces a cellulose nanofiber surfactant system that effectively envelops solid lipid microparticles (SLMs) by modifying the fiber surface with different alkyl chain structures. The research shows that alkyl chains with specific molecular structures can facilitate the assembly of cellulose nanofibers at the lipid-water interface, resulting in the formation of a dense and tough fibrillary membrane that envelopes the SLMs. Furthermore, this technology enables the immobilization of oil-soluble antioxidants while maintaining their long-term storage stability.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Nanoscience & Nanotechnology
Chun-Dong Xue, Jia-Ming Zhao, Zhong-Ping Sun, Jing-Tong Na, Yong-Jiang Li, Kai-Rong Qin
Summary: This study proposes a novel strategy for microfluidic focusing of microparticles based on negative magnetophoresis and oscillatory flow. A simulation model is developed to calculate particle motion and analyze the non-monotonic size dependence of particle focusing. The effects of oscillatory flow field and magnetic field on particle focusing are quantitatively investigated. The proposed strategy can guide real applications such as the enrichment and separation of sensitive biological particles.
MICROFLUIDICS AND NANOFLUIDICS
(2021)
Article
Pharmacology & Pharmacy
Eliza Wolska, Martyna Szymanska
Summary: The release profiles of active substances from microspheres in solid lipid microparticles (SLM) are crucial but difficult to compare due to the lack of clearly defined testing methods and conditions for novel dosage forms. This study aimed to identify influencing factors and choose the most appropriate method for testing drug substance release from SLM. Different dissolution methods were used, and significant differences were observed in release profiles depending on the chosen method, membrane, acceptor fluid, and concentration differences. The method using a dialysis bag was selected as the most suitable.
Article
Fisheries
Manish Mahotra, Hong Yu, Qunying Xu, Woei Chang Liew, Sharad Kharel, Lydia Shun En Tan, Say Chye Joachim Loo
Summary: This study investigated the use of Solid Lipid Microparticles (SLMs) as a microencapsulation system for methionine in fish feed. The results showed that SLMs provided slow release of methionine and Trimyristin-based SLMs had better digestion in fish.
Article
Nanoscience & Nanotechnology
Iat Wai Leong, Makusu Tsutsui, Kazumichi Yokota, Sanae Murayama, Masateru Taniguchi
Summary: By using partial dielectric coatings, the nonlinear ionic current through a pore can be altered, allowing the pore to behave like a resistor, diode, and bipolar junction transistor. The reasons for asymmetric ion transport in the pore and the relationship between specifically charged surfaces and electroosmotic flow are revealed through numerical simulations. These findings provide a direct approach to modify the electroosmotic-flow-driven ionic current rectification in channel-based devices via dielectric coatings.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Ming-Lin Yeh, Geng-Ming Chang, Yi-Je Juang
Summary: This study proposed and demonstrated the conformal coating of microparticles with a positively charged polyelectrolyte using an acoustofluidic microchip. The results showed that the microfluidic approach achieved rapid and uniform coating of microparticles. The zeta potentials of the coated microparticles exhibited charge reversal, with little variation influenced by the microchannel width or PAH concentration.
Article
Engineering, Chemical
Chao Yang, Ning Sun, Ziqiang Zhang, Baoqing Liu
Summary: The study investigated the combination of a coaxial mixer with micromixing in solid-liquid systems, finding that the outer impeller significantly improved micromixing performance but had limitations at high speeds. Additionally, the corotation mode was found to be more economical and efficient than the counter-rotation mode in terms of power and segregation index.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Cell Biology
Francesca Mancuso, Mario Calvitti, Domenico Milardi, Giuseppe Grande, Giulia Falabella, Iva Arato, Stefano Giovagnoli, Federica Vincenzoni, Francesca Mancini, Claudio Nastruzzi, Maria Bodo, Tiziano Baroni, Massimo Castagnola, Riccardo Marana, Alfredo Pontecorvi, Riccardo Calafiore, Giovanni Luca
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2018)
Article
Toxicology
Francesca Mancuso, Iva Arato, Cinzia Lilli, Catia Bellucci, Maria Bodo, Mario Calvitti, Maria Chiara Aglietti, Marco dell'Omo, Claudio Nastruzzi, Riccardo Calafiore, Giovanni Luca, Lorella Marinucci
TOXICOLOGY IN VITRO
(2018)
Article
Polymer Science
Elisabetta Esposito, Maddalena Sguizzato, Christian Bories, Claudio Nastruzzi, Rita Cortesi
Article
Pharmacology & Pharmacy
Elisabetta Esposito, Alessandra Pecorelli, Maddalena Sguizzato, Markus Drechsler, Paolo Mariani, Federica Carducci, Franco Cervellati, Claudio Nastruzzi, Rita Cortesi, Giuseppe Valacchi
CURRENT DRUG DELIVERY
(2018)
Article
Materials Science, Multidisciplinary
Gabriele Pitingolo, Antoine Riaud, Claudio Nastruzzi, Valerie Taly
ADVANCED ENGINEERING MATERIALS
(2019)
Article
Biochemical Research Methods
Gabriele Pitingolo, Valerie Taly, Claudio Nastruzzi
Article
Chemistry, Analytical
Gabriele Pitingolo, Antoine Riaud, Claudio Nastruzzi, Valerie Taly
Review
Pharmacology & Pharmacy
Elisabetta Esposito, Claudio Nastruzzi, Maddalena Sguizzato, Rita Cortesi
CURRENT PHARMACEUTICAL DESIGN
(2019)
Article
Nanoscience & Nanotechnology
Elisabetta Esposito, Maddalena Sguizzato, Markus Drechsler, Paolo Mariani, Federica Carducci, Claudio Nastruzzi, Giuseppe Valacchi, Rita Cortesi
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2019)
Article
Nanoscience & Nanotechnology
Silvia Mannucci, Federico Boschi, Barbara Cisterna, Elisabetta Esposito, Rita Cortesi, Claudio Nastruzzi, Enrica Cappellozza, Paolo Bernardi, Andrea Sbarbati, Manuela Malatesta, Laura Calderan
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Article
Pharmacology & Pharmacy
Fatih Yanar, Ali Mosayyebi, Claudio Nastruzzi, Dario Carugo, Xunli Zhang
Article
Chemistry, Analytical
Anna Nastruzzi, Gabriele Pitingolo, Giovanni Luca, Claudio Nastruzzi
Article
Medicine, Research & Experimental
Letizia Penolazzi, Elisabetta Lambertini, Stefania D'Agostino, Michela Pozzobon, Maria Pina Notarangelo, Pantaleo Greco, Pasquale De Bonis, Claudio Nastruzzi, Roberta Piva
Summary: The ability of degenerate intervertebral disc (IVD) cells to respond to physiological conditions in their niche, such as hypoxic environment and trophic factors, was investigated. Results showed that degenerate IVD cells were able to re-acquire discogenic phenotype and adapt to hypoxia after exposure to appropriate stimuli. This study opens new possibilities for engineering IVD by manipulating degenerated IVD cells to promote cell activity and repair.
Article
Materials Science, Multidisciplinary
Anna Nastruzzi, Franco Cicerchia, Annalisa Fortini, Claudio Nastruzzi
Summary: Infections acquired in public spaces pose a burden on health systems, and antimicrobial material surfaces play a role in infection prevention.
EMERGENT MATERIALS
(2021)
Article
Multidisciplinary Sciences
Elisabetta Esposito, Maddalena Sguizzato, Markus Drechsler, Paolo Mariani, Federica Carducci, Claudio Nastruzzi, Rita Cortesi
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)