Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Review
Immunology
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
Summary: The lungs have an immune defense mechanism that uses various cells to eliminate harmful pathogens and activate T cell immune response. In addition to immune cells, other lung cells also participate in antigen presentation and T cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alice Coillard, Elodie Segura
Summary: This study reviews the research on mouse mo-DC, evaluates the in vivo evidence for monocyte-derived antigen-presenting cells, and proposes that mo-DC may present antigens to effector T cells locally in tissues, playing a complementary role to cDCs.
MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takuya Sakamoto, Terutsugu Koya, Misa Togi, Kenichi Yoshida, Tomohisa Kato, Yasuhito Ishigaki, Shigetaka Shimodaira
Summary: This study evaluated the function and preclinical validation of human dendritic cell (DC) dexosomes, small DC-secreted vesicles that contain immune signals, for cancer vaccination. The researchers characterized a potential dexosome model using immature and mature DCs derived from a cell line called MUTZ3, and found that one type of MUTZ3-derived DC dexosomes exhibited potential immunogenicity and higher antigen presentation potency, making them potential resources for cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Tim B. Fessenden, Lauren E. Stopfer, Fiona Chatterjee, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Esmee P. Hoefsmit, Christian Blank, Forest White, Stefani Spranger
Summary: Cytotoxic CD8(+) T cells must recognize tumor-derived antigens to achieve effective tumor elimination. Our study shows that dendritic cells induce cytotoxic CD8(+) T-cell responses by cross-presenting tumor-derived peptides, and the proportion of membrane-derived neoantigens is associated with reduced survival and treatment response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biotechnology & Applied Microbiology
Juan Yu, Chaoqun Xu, Chuanwei Lu, Qian Liu, Jifu Wang, Fuxiang Chu
Summary: The sustainable polymeric micelles synthesized from rosin and vegetable oils via ATRP demonstrate great promise for efficient doxorubicin delivery and potential industrial applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Veterinary Sciences
Patricia Cunha, Florence B. Gilbert, Jennifer Bodin, Lise Godry, Pierre Germon, Sebastien Holbert, Rodrigo Prado Martins
Summary: Dendritic cells are important for understanding the immune response and can be produced in a simplified manner using conventional and serum-free media. These cells can be used for flow cytometry-based antigen presentation assays with fresh or frozen cells. The simplified protocols described in this study are significant for studying cell-mediated immune responses in bovine.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Physical
Peng Ding, Wei Liu, Xuhong Guo, Martien A. Cohen Stuart, Junyou Wang
Summary: The study systematically investigates the effects of pH, salt concentration, and cross-linker fractions on the formation and properties of PDMAEMA nanogels, achieving important breakthroughs in optimizing and controlling the synthesis of nanogels. The obtained PDMAEMA nanogel exhibits dual-responses to pH and salt, allowing for selective loading and controlled release of substances.
Review
Immunology
Ray A. Ohara, Kenneth M. Murphy
Summary: Cross-priming, initially recognized in cytotoxic T lymphocyte (CTL) responses, involves the presentation of minor histocompatibility antigens by antigen presenting cells (APCs) derived from immunizing cells. As understanding of T cell receptor antigen recognition progressed, cross-priming was redefined as cross-presentation and expanded to include different forms of antigens and APCs not involved in in vivo CTL priming. In vitro cell models have been utilized for studying cross-presentation, but recent studies have shown differences between these models and in vivo APCs. Current research focuses on validating in vivo pathways and gene candidates for cross-presentation, and evaluating their contributions to CTL responses across different antigens and immunologic settings.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Carolina Henriques Cavalcante, Renata Salgado Fernandes, Juliana de Oliveira Silva, Caroline Mari Ramos Oda, Elaine Amaral Leite, Geovanni Dantas Cassali, Ives Charlie-Silva, Bianca Helena Ventura Fernandes, Lucas Antonio Miranda Ferreira, Andre Luis Branco de Barros
Summary: The developed pH-sensitive micelles encapsulating DOX showed promising results with small diameter, high stability, low toxicity, and significantly better inhibition of tumor growth compared to other forms of DOX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Zuha Imtiyaz, Jiaxi He, Qixin Leng, Atul K. Agrawal, A. James Mixson
Summary: Researchers are exploring various nanoparticle methods to deliver chemotherapeutic agents to tumors with higher accumulation. pH-dependent histidine-based nanoparticles show promising potential for treatment, but challenges remain in clinical trials.
Article
Cell Biology
Ryosuke Tashiro, Kuniyasu Niizuma, Jun Kasamatsu, Yuko Okuyama, Sherif Rashad, Atsuo Kikuchi, Miki Fujimura, Shigeo Kure, Naoto Ishii, Teiji Tominaga
Summary: The study found that RNF213 plays a critical role in antigen uptake, processing, and presentation, with Rnf213-KO and Rnf213-KI mice experiments showing that RNF213 deficiency leads to decreased antigen uptake and processing capabilities, resulting in the inability to effectively activate antigen-specific T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dandan Liu, Xiangmin Ding, Jian Ding, Jing Sun
Summary: This study analyzes the assemblies formed by charged polyelectrolytes via electrostatic interactions and demonstrates the superior stability of the polypeptoid/folic acid complex as compared to other polymers. By encapsulating the anticancer drug in the complex vesicles, enhanced therapeutic efficacy is achieved through receptor-mediated endocytosis. pH-responsive morphological transformations were also observed.
Article
Polymer Science
Meirong Zhao, Weiwei Jiang, Xinrong Xie, Yogini Jaiswal, Leonard Williams, Mei Wei, Ying Mo, Yifu Guan, Hua Yang
Summary: In this paper, a new drug carrier was synthesized using self-assembled polymeric micelles to load paclitaxel. The drug-loading content of the carrier prepared by the optimized method was 1.97%. The results indicate that the developed carrier has good pH sensitivity and potential for increased solubility and clinical efficacy of paclitaxel.
Article
Chemistry, Physical
Shuting Wang, Yu Fang, Zequn Zhang, Qiao Jin, Jian Ji
Summary: In this study, pH-responsive prodrug micelles were prepared to enhance the antimicrobial activity of photodynamic therapy, demonstrating negative charge in normal physiological environment and turning to positive charge in bacterial infection microenvironment for improved antibacterial activity. These micelles have shown great potential in the treatment of stubborn bacterial infections, as proven by in vivo experiments.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
L. Simon, N. Marcotte, J. M. Devoisselle, S. Begu, V. Lapinte
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Chemistry, Medicinal
Koceila Doufene, Yohan Malki, Laure-Anais Vincent, Pierre Cuq, Jean-Marie Devoisselle, Nicolas Masurier, Anne Aubert-Pouessel
Summary: This study aimed to conduct a preformulation study on JMV5038 as a new potent cytotoxic agent and to develop its formulation within vegetable oil-based hybrid submicron particles to combat melanoma. JMV5038-loaded HNP showed high loading efficiency and exhibited sustained release in vitro over one month, with slightly enhanced cytotoxic activity against melanoma cells while maintaining safety on NIH 3T3 cells. The results suggest that JMV5038-loaded HNP could serve as an efficient and safe drug delivery system for further evaluation in preclinical studies.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Koceila Doufene, Ilaria Basile, Aurelien Lebrun, Nelly Pirot, Aurelie Escande, Joel Chopineau, Jean-Marie Devoisselle, Nadir Bettache, Anne Aubert-Pouessel
Summary: The study demonstrated the potential of vegetable oil-based hybrid microparticles as an efficient and safe drug delivery system for subcutaneous administration. These microparticles, prepared through a specific process, were able to encapsulate and release active ingredients, while also showing biocompatibility in both cell and animal models.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Daria Mamaeva, Zhour Jazouli, Mattia L. DiFrancesco, Nejla Erkilic, Gregor Dubois, Cecile Hilaire, Isabelle Meunier, Hassan Boukhaddaoui, Vasiliki Kalatzis
Summary: This study investigates the role of different ion channels in human-induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium (RPE) functions. The research demonstrates the importance of various channels in processes such as phagocytosis and vascular endothelial growth factor (VEGF) secretion, highlighting the potential of hiPSC-derived RPE as a model for studying RPE functions.
Article
Chemistry, Multidisciplinary
Giang Ngo, Gautier Felix, Christophe Dorandeu, Jean-Marie Devoisselle, Luca Costa, Pierre-Emmanuel Milhiet, Yannick Guari, Joulia Larionova, Joel Chopineau
Summary: By controlling parameters such as precursor concentration, nature of functional groups, or lipid properties, fine control over the size, morphology, and surface coverage of Prussian Blue nanostructures can be achieved. This approach allows the growth of PB nanopyramids and nanocubes on different surfaces, as well as the design of thin films over a wide area.
Article
Chemistry, Physical
L. Simon, C. Picard, L. S. Calixto, V Lapinte, J. M. Devoisselle, S. Begu
Summary: The study evaluated the behavior of polyoxazolines based mixed micelles and lipid nanocapsules on a nonbiological human skin surface model, assessing their potential for topical delivery. The research found that both formulations showed good affinity with the skin surface and the residual film left on the surface modified the skin model physicochemical properties, leading to a better interaction with hydrophilic and polar compounds. The impact of each excipient on the surface physicochemical properties further explained the resulting formulation behavior on the skin surface model, highlighting the crucial role of the main component.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Multidisciplinary
Alexis Fayd'herbe De Maudave, Wilhem Leconet, Karine Toupet, Michael Constantinides, Guillaume Bossis, Marion de Toledo, Jerome Vialaret, Christophe Hirtz, Adolfo Lopez-Noriega, Christian Jorgensen, Daniele Noel, Pascale Louis-Plence, Sylvestre Grizot, Martin Villalba
Summary: Monoclonal antibodies have high therapeutic potential for cancer or autoimmune diseases, but intravenous administration can lead to off-target effects. Utilizing a local controlled-delivery approach with in situ forming depot technology can help address this issue.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Cell Biology
Amel Nasri, Florent Foisset, Engi Ahmed, Zakaria Lahmar, Isabelle Vachier, Christian Jorgensen, Said Assou, Arnaud Bourdin, John De Vos
Summary: Mesenchymal cells play crucial roles in lung development, regeneration, and diseases, especially in chronic obstructive pulmonary disease.
Review
Biochemistry & Molecular Biology
Yujie Song, Christian Jorgensen
Summary: This review highlights the potential of mesenchymal stromal cells (MSCs) in treating osteoarthritis (OA), focusing on their chondrogenic and immunomodulatory potential. The review provides an overview of the effects of MSCs in preclinical and clinical studies of OA treatment, comparing different MSC sources. Furthermore, the review summarizes the current evidence for the assessment of cartilage in OA using magnetic resonance imaging (MRI) and second-look arthroscopy after MSC therapy.
Article
Cell & Tissue Engineering
Carla Sanjurjo-Soriano, Nejla Erkilic, Krishna Damodar, Hassan Boukhaddaoui, Michalitsa Diakatou, Marcela Garita-Hernandez, Daria Mamaeva, Gregor Dubois, Zhour Jazouli, Carla Jimenez-Medina, Olivier Goureau, Isabelle Meunier, Vasiliki Kalatzis
Summary: This study demonstrates the importance of supplemented media for culturing retinal organoids and shows that retinoic acid plays a crucial role in inducing rod cell fate and enhancing the organization of the photoreceptor layer.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Extracellular vesicles (EVs) isolated from induced pluripotent stem cells (iMSCs) show promise in regenerative medicine for the treatment of various diseases. However, the heterogeneity between MSC donors may lead to batch-to-batch variability in the use of EVs as cell-free therapeutic agents.
Article
Chemistry, Medicinal
Benoit Gautier, Melanie Fore Jacquard, Sophie Guelfi, Scarlette Abbou, Elisa Gonzalez, Jade Berthelot, Hassan Boukhaddaoui, Aurelien Lebrun, Baptiste Legrand, Nicolas Tricaud, Nicolas Inguimbert
Summary: This study investigates the binding mechanism of VDAC, the most abundant protein on the outer mitochondrial membrane, to HK and enhances its ability to prevent peripheral nerve demyelination by modifying peptides. The findings provide new insights into the interaction between VDAC and HK, potentially leading to the development of therapeutic compounds for demyelinating peripheral neuropathies.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Corine Tourne-Peteilh, Maeva Barege, Mathieu Lions, Jean Martinez, Jean-Marie Devoisselle, Anne Aubert-Pouessel, Gilles Subra, Ahmad Mehdi
Summary: Hybrid hydrogels based on silylated polyethylene glycol (Si-PEG) were evaluated as matrices for controlled release of bovine serum albumin (BSA), with investigations into the parameters affecting the hydrogel structure and protein release behavior. The study provided insights into the stability, swelling, and mechanical properties of the network, as well as the impact of different factors on the protein release profiles.
Article
Materials Science, Biomaterials
Maelle Cahu, Lamiaa M. A. Ali, Saad Sene, Jerome Long, Franck Camerel, Mathieu Ciancone, Fabrice Salles, Joel Chopineau, Jean-Marie Devoisselle, Gautier Felix, Nicolas Cubedo, Mireille Rossel, Yannick Guari, Nadir Bettache, Joulia Larionova, Magali Gary-Bobo
Summary: Through a one-step self-assembly reaction, Mn2+ can replace up to 32% of Fe3+ in the Prussian blue structure, with higher proportions resulting in a different structure. The photothermal conversion efficiency of the nanoparticles is dependent on the Mn/Na-Mn-Fe ratio and nanoparticle concentration. Evaluation on MDA-MB-231 cells confirmed the excellent photothermal efficiency of these nanoparticles.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Pharmacology & Pharmacy
Sarah Le Saux, Anne Aubert-Pouessel, Lyria Ouchait, Khaled Elhady Mohamed, Pierre Martineau, Laurence Guglielmi, Jean-Marie Devoisselle, Philippe Legrand, Joel Chopineau, Marie Morille
Summary: This article highlights the importance of proteins as drugs, discusses the significance of intracellular targeting therapy, explores the challenges faced by therapeutic proteins, and reviews the latest advancements in delivery system research.
ADVANCED THERAPEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)