期刊
JOURNAL OF CONTROLLED RELEASE
卷 152, 期 3, 页码 349-355出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2011.02.026
关键词
Microprojection; Vaccine coating; Thermostability
资金
- Australian Research Council [DP077464]
- National Health and Medical Research Council [569726, 456150]
- Queensland Government, Australia
- Bill & Melinda Gates Foundation
Dry-coated microprojections can deliver vaccine to abundant antigen-presenting cells in the skin and induce efficient immune responses and the dry-coated vaccines are expected to be thermostable at elevated temperatures. In this paper, we show that we have dramatically improved our previously reported gas-jet drying coating method and greatly increased the delivery efficiency of coating from patch to skin to from 6.5% to 32.5%, by both varying the coating parameters and removing the patch edge. Combined with our previous dose sparing report of influenza vaccine delivery in a mouse model, the results show that we now achieve equivalent protective immune responses as intramuscular injection (with the needle and syringe), but with only 1/30th of the actual dose. We also show that influenza vaccine coated microprojection patches are stable for at least 6 months at 23 degrees C. inducing comparable immunogenicity with freshly coated patches. The dry-coated microprojection patches thus have key and unique attributes in ultimately meeting the medical need in certain low-resource regions with low vaccine affordability and difficulty in maintaining cold-chain for vaccine storage and transport. (C) 2011 Elsevier B.V. All rights reserved.
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