Article
Chemistry, Applied
Fan Jiang, Chunwei Du, Ning Zhao, Wenqian Jiang, Xiuzhu Yu, Shuang-kui Du
Summary: Quinoa starch nanoparticles (QSNPs) prepared under optimal conditions as a carrier for quercetin showed smaller particle size and higher loading capacity compared to maize starch nanoparticles (MSNPs), resulting in more effective protection and prolongation of quercetin bioactivity.
Article
Chemistry, Multidisciplinary
Joseph Rosenfeld, Francois Ganachaud, Daeyeon Lee
Summary: Flow-based nanoprecipitation, which involves rapid mixing of two miscible liquids, is a scalable strategy for manufacturing nanoparticles with various shapes and morphologies. However, controlling the size of nanoparticles in this process is often done through empirical variations in flow rate ratios or total flow rate. In this study, coprecipitation of oil and polymer to form nanocapsules was investigated using glass capillary microfluidics, revealing the importance of supersaturation in determining the average diameter of the fabricated capsules. The control over nanocapsule size by varying the extent of supersaturation provides a systematic approach to controlling the size of nanoparticles via continuous nanoprecipitation.
Review
Biochemistry & Molecular Biology
Guangyan Zhang, Hui Yi, Chenhui Bao
Summary: Poly(aspartamide) derivatives, with excellent biocompatibility and biodegradability, are suitable for biomedical applications. Stimuli-responsive poly(aspartamide) derivatives can be used for drug release and control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Meliha Ekinci, Clenilton Costa dos Santos, Luciana Magalhaes Rebelo Alencar, Hasan Akbaba, Ralph Santos-Oliveira, Derya Ilem-Ozdemir
Summary: The necessity of new drugs for lung cancer therapy and imaging is increasing, and the development of specific and selective drugs capable of reaching the tumor is required. This study successfully developed and characterized target-specific atezolizumab-conjugated PLA/PVA nanoparticles for lung cancer diagnosis and therapy. The results showed good in vitro efficacy, demonstrating the potential of these nanoparticles for clinical applications.
Article
Biochemistry & Molecular Biology
Marta Rubio-Camacho, Maria Jose Martinez-Tome, Amalia Mira, Ricardo Mallavia, Carmen Reyes Mateo
Summary: This study developed fluorescent nanoparticles with pH-sensitive properties, capable of holding drugs in acidic media and releasing them at physiological pH. Furthermore, these nanoparticles have potential use as image probes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Xu Fang, Yunan Qing, Yan Lou, Xin Gao, Hao Wang, Xingyue Wang, Yixuan Li, Yanguo Qin, Junqi Sun
Summary: This study fabricates poly(vinyl alcohol) (PVA)-based supramolecular plastics capable of degrading in soil and recycling under mild conditions. The plastics exhibit satisfactory mechanical strength in watery environment due to the hydrogen-bond-cross-linked hydrophobic domains, and can rapidly degrade into harmless hydrogel pieces in seawater.
ACS MATERIALS LETTERS
(2022)
Article
Polymer Science
Cristiana L. Zaccaria, Valeria Cedrati, Andrea Nitti, Enrica Chiesa, Antxon Martinez de Ilarduya, Montserrat Garcia-Alvarez, Massimiliano Meli, Giorgio Colombo, Dario Pasini
Summary: A novel approach for constructing biocompatible graft copolymers starting from bacterial poly(gamma-glutamic acid) and incorporating poly(lactic acid) was reported. The synthesis strategy is controlled at different levels to achieve controlled grafting of polylactic fragments to bacterial gamma-PGA propargyl ester. Characterization of the graft copolymers includes thermal and macromolecular properties, molecular modeling for conformational preferences, and evaluation of cytotoxicity.
Article
Pharmacology & Pharmacy
Austin D. Fergusson, Rui Zhang, Judy S. Riffle, Richey M. Davis
Summary: Flash nanoprecipitation (FNP) is a reliable method for producing polymer nanoparticles loaded with hydrophobic drugs. By incorporating ion pairing agents (IPs) into the FNP formulation, hydrophobic drug salts can be efficiently precipitated. In this study, we investigated the effects of two hydrophobic IPs, palmitic acid (PA) and hexadecylphosphonic acid (HDPA), on the loading and size of LY294002-loaded nanoparticles. HDPA resulted in well-defined colloidally stable particles, while PA resulted in ill-defined aggregates. This approach opens up possibilities for intravenous administration of previously unusable hydrophobic drugs.
Article
Polymer Science
Bruna Vieira Tiburcio, Livia Rodrigues de Menezes, Laura Coelho Merat, Lizandra Viana Maurat da Rocha, Emerson Oliveira da Silva, Maria Ines Bruno Tavares
Summary: Orange oil was encapsulated in PCL/Pluronic F68-based nanoparticles prepared by the nanoprecipitation technique. The encapsulation improved the solubility of orange oil and maintained its properties. The nanosystems had monodispersed distributions and nanometric diameters. The encapsulated orange oil exhibited stabilizing and cryoprotective effects on the colloidal dispersions, and its release sustained for approximately 7 h.
Article
Chemistry, Physical
Voitto Kankanen, Micaela Fernandes, Zehua Liu, Jani Seitsonen, Sami-Pekka Hirvonen, Janne Ruokolainen, Joao F. Pinto, Jouni Hirvonen, Vimalkumar Balasubramanian, Helder A. Santos
Summary: This study reports the development of poly(ethylene glycol)-block-(e-caprolactone) (PEG-b-PCL) nanoparticles using a microfluidic technique for intravenous drug delivery. The optimized formulation achieved spherical morphology, small particle size (dH < 80 nm), uniform size distribution (PDI < 0.2), high drug loading degree (16%), and encapsulation efficiency of 54%. Furthermore, the nanoparticles exhibited stability and sustained release of sorafenib in vitro over several days. Overall, this research demonstrates the use of microfluidic approach in optimizing drug delivery systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Atharva R. Bhide, Anil B. Jindal
Summary: The objective of this study was to prepare and evaluate artemether-loaded PLGA nanorods through mechanical stretching of nanospheres, demonstrating sustained drug release and lower hemolysis compared to nanospheres. This method provides a new approach for intravenous delivery of antimalarial drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biophysics
Da-xia Zhang, Rui Wang, Haichao Cao, Jian Luo, Tong-fang Jing, Bei-xing Li, Wei Mu, Feng Liu, Youming Hou
Summary: A study was conducted to synthesize an ecofriendly polymer for nanogel delivery system of pesticide, which showed favorable stability and efficient pest control under various conditions. The nanogel demonstrated prolonged pest control period and effective bioactivity against pests, indicating a promising future for pesticide delivery.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Yulia A. Kadina, Ekaterina V. Razuvaeva, Dmitry R. Streltsov, Nikita G. Sedush, Eleonora V. Shtykova, Alevtina I. Kulebyakina, Alexander A. Puchkov, Dmitry S. Volkov, Alexey A. Nazarov, Sergei N. Chvalun
Summary: Nanoparticles based on biocompatible mPEG(113)-b-P(D,L)LA(n) copolymers were prepared for the delivery of the anticancer agent oxaliplatin via a nanoprecipitation technique. It was found that an increase in the hydrophobic PLA block length resulted in larger nanoparticle size and decreased oxaliplatin loading content.
Article
Chemistry, Physical
Ekaterina Razuvaeva, Nikita Sedush, Evgeniya Shirokova, Stanislav Moskvichev, Dmitry Streltsov, Sergei Chvalun
Summary: This study synthesized spherical nano-sized particles of poly(D,L-lactide-co-glycolide) (PLGA) using a non-toxic catalyst and a nanoprecipitation method. The effect of formulation parameters on the properties of PLGA particles was investigated. The formation mechanism and stabilization factors of the PLGA particles were proposed and analyzed.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Polymer Science
Mahdi Forouharshad, Fatemeh Ajalloueian
Summary: The study demonstrated that by making small changes in the process parameters, it is possible to adjust the entrapment efficiency and modify the release rate of the drug without altering the physical properties of the original drug substance and polymer.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)