Article
Chemistry, Multidisciplinary
Binglin Sui, Mingming Wang, Chen Cheng, Quanguang Zhang, Jiajia Zhang, Daping Fan, Peisheng Xu
Summary: The Nano-ERASER technique, utilizing an antibody-conjugated polymer nanogel system, facilitates targeted intracellular delivery, release, and degradation of specific endogenous proteins, showing promising efficacy and convenience in studying protein function and potentially serving as a novel therapeutic modality for cancer and other diseases.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Polymer Science
Brielle Stawicki, Tyler Schacher, Hyunah Cho
Summary: Chemotherapy and radiation are mainstays in cancer treatment globally, but some therapies have limited specificity and cause harsh side effects in patients. Nanogels, as a unique drug delivery system, show promise in the treatment of brain cancer, despite complications such as handling and chemical stability. Ongoing development of nanogels offers a patient-centered approach for managing brain cancer.
Article
Polymer Science
Ngoc The Nguyen, Quynh Anh Bui, Hoang Huong Nhu Nguyen, Tien Thanh Nguyen, Khanh Linh Ly, Ha Le Bao Tran, Vu Nguyen Doan, Tran Thi Yen Nhi, Ngoc Hoa Nguyen, Ngoc Hao Nguyen, Ngoc Quyen Tran, Dinh Trung Nguyen
Summary: This study successfully developed a nanogel capable of co-loading curcuminoid and cisplatin hydrate, demonstrating high stability and accelerated drug release. In vitro and in vivo experiments confirmed the significant antitumor activity and prolonged survival time achieved by the dual-drug platform.
Article
Biochemistry & Molecular Biology
Francesca Anson, Pintu Kanjilal, S. Thayumanavan, Jeanne A. Hardy
Summary: Cytosolic protein delivery shows promise in various applications. However, the use of fluorescent tags can lead to undesired consequences which are often overlooked, making distinguishing between cytosolically released and endosomally entrapped proteins challenging. The development of a caspase-3 variant tagged with GFP aims to address this issue and facilitate the study of therapeutic properties and apoptotic cell death mechanisms.
Article
Chemistry, Multidisciplinary
Tianbao Chen, Jie Xu, Lijuan Zhu, Deyue Yan
Summary: Researchers developed a targeted nanodrug delivery system using the cationic amphiphilic chemodrug mitoxantrone (Mito), which interacts with Bcl-2 ASO through electrostatic interaction and self-assembles into nanoparticles (NP[Bcl-2/Mito]). NP[Bcl-2/Mito] protects the ASO from degradation during delivery and combines gene- and chemotherapies to improve the anticancer effect. Cancer cell membranes (CCMs) derived from homologous tumors were used to camouflage NP[Bcl-2/Mito] (NP[Bcl-2/Mito]@CCM) for immune escape and tumor targeting. Both in vitro and in vivo assessments demonstrate the excellent performance of NP[Bcl-2/Mito]@CCM for drug-resistant breast tumor therapy.
Article
Chemistry, Multidisciplinary
Aroa Duro-Castano, Ana Sousa-Herves, Ana Arminan, David Charbonnier, Juan Jose Arroyo-Crespo, Stefanie Wedepohl, Marcelo Calderon, Maria J. Vicent
Summary: The research team utilized poly-amino acid-based nanogels (NGs) as a drug delivery platform to successfully inhibit TNBC lung metastasis and almost completely suppress lymph node metastasis in a mouse model.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Sachchidanand Tiwari, Surender Kharbanda, Harpal Singh
Summary: The disruption and overexpression of the PI3K-AKT signaling pathway in cancer can be targeted by co-delivery of a PI3-K delta/HDAC6 dual inhibitor and Epirubicin using polymeric nanoparticles, resulting in increased efficacy and reduced toxicity of the anti-cancer treatment.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Materials Science, Multidisciplinary
Xiangke Zhang, Ming Chen, Yuping Kan, Yumeng Dong, Xinyu Zhang, Xueying Wang, Hui Su, Shiyi Xu, Xueying Yan
Summary: Doxorubicin and indocyanine green were loaded into silica nanoparticles and wrapped with manganese dioxide to create DOX-IR820@MSN-MnO2 nanoparticles. These nanocomposites exhibit tumor microenvironment response characteristics and excellent photodynamic and photothermal properties. The combination therapy using these nanoparticles significantly reduces cell viability and shows promising applications in cancer treatment.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Applied
Jae-Hyeon Lee, Seong-Bin Yang, Jun-Hyuck Lee, Hansol Lim, Seokwoo Lee, Tae-Bong Kang, Ji-Hong Lim, Young Jun Kim, Jooho Park
Summary: In this study, heparin was used as a drug carrier to directly conjugate the anticancer drug doxorubicin, forming heparin-doxorubicin conjugates. These conjugates exhibited significant cytotoxicity to CT26 tumor cells by generating reactive oxygen species, without increasing anticoagulant activity. The self-assembled nanoparticles of heparin-doxorubicin conjugates effectively inhibited tumor growth and metastasis in CT26-bearing Balb/c animal models. Therefore, this cytotoxic doxorubicin-based heparin conjugate holds promise as a potential new anticancer therapeutic.
CARBOHYDRATE POLYMERS
(2023)
Article
Polymer Science
Hyun-Chul Kim, Eunjoo Kim, Se Guen Lee, Sung Jun Lee, Sang Won Jeong, Young Jae Lee, Mi Kyung Kwon, Seong-Kyoon Choi, Jun Seong Hwang, Eunsook Choi
Summary: ROS-responsive nanocarriers have been synthesized for controlled release of anticancer drugs. The DTTP micelles are highly sensitive to ROS, releasing drugs in tumor cells with strong antitumor activity.
Article
Biochemistry & Molecular Biology
Zifei Han, Shelli R. McAlpine, Robert Chapman
Summary: This study demonstrates the successful delivery of inhibitors to block the interaction between Hsp70 and HOP using polymer nanogels. The results show the effectiveness of these inhibitors in inhibiting Hsp70 and inducing cancer cell death.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ali Maruf, Malgorzata Milewska, Anna Lalik, Sebastian Student, Ilona Wandzik
Summary: In this study, acrylamide-based nanogels containing cationic groups and redox-sensitive crosslinkers were developed for cellular delivery of anti-miR21 (a-miR21). Successful miRNA loading was confirmed and stable miRNA release was achieved.
Article
Chemistry, Multidisciplinary
Hae Hyun Hwang, Hyung Shik Kim, Dong Yun Lee
Summary: The conjugate of lactoferrin and heparin can attenuate angiogenic activity by binding to growth factors around the tumor tissue, and it can be orally absorbed and delivered to brain tumors through the blood-brain barrier. It inhibits angiogenesis in glioblastoma and shows potential as a new oral medication for treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
Sachchidanand Tiwari, Priya Gupta, Mohd Anees, Harshdeep Kaur, Surender Kharbanda, Harpal Singh
Summary: In this study, a series of novel Pluronic(R)-modified PLA based hybrid block copolymers were synthesized for the encapsulation of Epirubicin, aiming to reduce its toxicity and enhance anti-cancer therapeutic efficacy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biophysics
Hong Yu Yang, Moon-Sun Jang, Yi Li, Jia Meng Du, Changling Liu, Jung Hee Lee, Yan Fu
Summary: In this study, a chlorine e6-functionalized and pH-responsive dynamically cross-linked nanogel was developed for co-delivery of photosensitizers and protein drugs to enhance the efficiency of synergistic cancer therapy. The nanogel demonstrated excellent systemic stability under normal physiological conditions and could be further cationized to enhance cell uptake in acidic extracellular environment. Upon internalization, the nanogel could release the photosensitizers and protein drugs, leading to the generation of cytotoxic singlet oxygen and improved photodynamic therapy of cancer.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Eugene Lih, Ki Wan Park, So Young Chun, Hyuncheol Kim, Tae Gyun Kwon, Yoon Ki Joung, Dong Keun Han
ACS APPLIED MATERIALS & INTERFACES
(2016)
Review
Pharmacology & Pharmacy
Mahmoud A. Elnaggar, Ramesh Subbiah, Dong Keun Han, Yoon Ki Joung
EXPERT OPINION ON DRUG DELIVERY
(2017)
Article
Polymer Science
Youngjin Cho, Si Yoong Seo, Bang Ju Park, Yoon Ki Joung, Dong Keun Han
MACROMOLECULAR RESEARCH
(2017)
Article
Materials Science, Biomaterials
Seong Min Kim, Sung-Bin Park, Tarek M. Bedair, Man-Ho Kim, Bang Ju Park, Yoon Ki Joung, Dong Keun Han
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2017)
Review
Polymer Science
Sung-Bin Park, Eugene Lih, Kwang-Sook Park, Yoon Ki Joung, Dong Keun Han
PROGRESS IN POLYMER SCIENCE
(2017)
Article
Chemistry, Multidisciplinary
Eugene Lih, Chang Hun Kum, Wooram Park, So Young Chun, Youngjin Cho, Yoon Ki Joung, Kwang-Sook Park, Young Joon Hong, Dong June Ahn, Byung-Soo Kim, Tae Gyun Kwon, Myung Ho Jeong, Jeffrey A. Hubbell, Dong Keun Han
Article
Engineering, Biomedical
Kwang-Sook Park, Byoung-Ju Kim, Eugene Lih, Wooram Park, Soo-Hong Lee, Yoon Ki Joung, Dong Keun Han
ACTA BIOMATERIALIA
(2018)
Article
Chemistry, Multidisciplinary
Hye Jung Jang, Sung-Bin Park, Tarek M. Bedair, Min-Kyu Oh, Dong-June Ahn, Wooram Park, Yoon Ki Joung, Dong Keun Han
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Eugene Lih, Wooram Park, Ki Wan Park, So Young Chun, Hyuncheol Kim, Yoon Ki Joung, Tae Gyun Kwon, Jeffrey A. Hubbell, Dong Keun Han
ACS CENTRAL SCIENCE
(2019)
Article
Chemistry, Multidisciplinary
Chungwon Park, Kwang-Sook Park, Mi Jin Jeong, Han Byul Kim, Inho Bae, Kyung Seob Lim, Mei-Xian Li, Young Joon Hong, Dong Keun Han, Yoon Ki Joung
Summary: A universal method of using cell-made extracellular matrices (ECMs) to coat substrates for therapeutic cell delivery is recommended to improve integration of implantable materials with surrounding tissues. ECM-coated substrates show promising results in supporting endothelial regeneration and inhibiting neointimal growth in in vivo experiments, making them more effective than traditional stents.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Su-Yeon Choi, Mei-Xian Li, Jong Hee Kang, Dae Hyeok Yang, Yoon Ki Joung
Summary: The study synthesized novel SMOs with zwitterion and fluorine for blending with PVC, enhancing anti-thrombotic performance through anti-fouling effect. Results showed successful migration of SMOs to the PVC surface, improving resistivity to adsorption and inhibiting platelet adhesion and activation for enhanced anti-thrombotic effect. The synergistic effect of sulfobetaine and fluorine in SMOs-blended PVCs demonstrated promising potential for anti-thrombotic surface modification in cardiovascular applications.
SURFACES AND INTERFACES
(2021)
Article
Cell & Tissue Engineering
Dong-Heon Ga, Chung-Man Lim, Yoonsun Jang, Tae Il Son, Dong Keun Han, Yoon Ki Joung
Summary: By combining zwitterionic polyurethane additives with metal ions, the hydrophilicity of polyurethanes was significantly improved, leading to enhanced anti-fouling effects. The introduction of metal ions decreased the effectiveness of the additives in protein adsorption tests.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Ju-Ro Lee, Woo-Sup Sim, Hun-Jun Park, Bong-Woo Park, Yoon Ki Joung
Summary: The modulation of inflammatory responses is important in the development of cardiac failure. In this study, apoptotic bodies-mimetic nanovesicles derived from apoptotic fibroblasts were developed as a therapeutic strategy for ischemia-reperfusion (IR)-injured hearts. These nanovesicles actively targeted the ischemic myocardium and polarized macrophages to alleviate inflammation. Injection of the nanovesicles attenuated cardiac remodeling and prevented cardiac function exacerbation in IR-injured hearts.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Engineering, Biomedical
Mei-Xian Li, Qian-Qi Wei, Hui-Lin Mo, Yu Ren, Wei Zhang, Huan-Jun Lu, Yoon Ki Joung
Summary: Arterial occlusive disease is a common cause of cardiovascular diseases that often requires revascularization. However, current synthetic vascular grafts have limitations in small-diameter applications due to infection, thrombosis, and intimal hyperplasia. The development of tissue engineering and regenerative medicine technology has allowed the creation of biological tissue-engineered vascular grafts that can integrate, remodel, and repair host vessels. This paper evaluates advanced fabrication technologies for small-diameter vascular grafts and discusses future perspectives for their clinical application.
BIOMATERIALS RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Mahmoud Elnaggar, Md Lemon Hasan, Suk Ho Bhang, Yoon Ki Joung
Summary: The study aimed to engineer an endothelium-mimetic surface using lipid bilayers extracted from endothelial cells with embedded organoselenium catalyst for nitric oxide generation. The resulting bilayer demonstrated endothelium-similar properties and selective responses to different cell types. This innovative approach provides valuable insights for the rational design and development of vascular implantable devices and potentially nonvascular biointerfacing devices.
ACS APPLIED BIO MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)