Review
Pharmacology & Pharmacy
Jia Nong, Patrick M. Glassman, Vladimir R. Muzykantov
Summary: Acute inflammation is a common component of many prevalent conditions, and targeting endothelial cells for therapeutic intervention shows promise in correcting the damaging effects of inflammation. However, current drugs and drug delivery systems lack precision and effectiveness.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Instruments & Instrumentation
Carlos A. Franco-Urquijo, J. Angel Navarro-Becerra, Amelia Rios, Bruno Escalante
Summary: The study evaluated a hybrid delivery system consisting of liposomes loaded with vascular agonists conjugated to microbubbles for targeted release using UMMD.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Lauren B. Grimsley, Phillip C. West, Callie D. McAdams, Charles A. Bush, Stacy S. Kirkpatrick, Joshua D. Arnold, Michael R. Buckley, Raymond A. Dieter, Michael B. Freeman, Michael M. McNally, Scott L. Stevens, Oscar H. Grandas, Deidra J. H. Mountain
Summary: The research has made progress in developing targeted liposomal nanocarriers for preferential collagen IV binding under static vascular flow conditions, showing potential for future clinical applications.
Article
Cell Biology
Sofia K. H. Morsing, Timo Rademakers, Sanne L. N. Brouns, Anne-Marieke D. van Stalborch, Marjo M. P. C. Donners, Jaap D. van Buul
Summary: The study reveals that endothelial ADAM10 plays a role in facilitating neutrophil transendothelial migration by cleaving ICAM-1, supporting the efficient release of neutrophils from the endothelium. Silencing or inhibiting endothelial ADAM10 leads to a significantly longer diapedesis step for neutrophils due to impaired dissociation from ICAM-1. Increased ICAM-1 levels on transmigrating neutrophils and potential membrane transfer from endothelium to neutrophils are also observed.
Review
Pharmacology & Pharmacy
Mah Noor Zafar, Waad H. Abuwatfa, Ghaleb A. Husseini
Summary: In order to improve current cancer treatments, nanomaterials are used as smart drug delivery vehicles that can be designed to specifically target cancer cells and respond to stimulation. These nanocarriers can encapsulate chemotherapy drugs and deliver them to the affected area, reducing the side effects associated with conventional systemic administration. Different sonosensitive liposomal formulations that can be stimulated using acoustic methods are discussed in this review. Emulsion liposomes (eLiposomes) are highlighted for their ability to promote drug release at low intensities and short exposure times compared to regular liposomes. Other formulations incorporating microbubbles and nanobubbles are also explored.
Review
Pharmacology & Pharmacy
Yanning Bao, Weiyue Lu
Summary: In recent years, cerebral diseases have posed a threat to public health. However, the blood-brain barrier makes it difficult for therapeutic proteins to enter the central nervous system. Fortunately, there have been emerging strategies to overcome this barrier and deliver macromolecular therapeutic proteins.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Biochemical Research Methods
Tri Vu, Yuqi Tang, Mucong Li, Georgii Sankin, Shanshan Tang, Shigao Chen, Pei Zhong, Junjie Yao
Summary: The study developed an integrated HIFU-PACT system for detecting vascular rupture in mechanical HIFU treatment. They demonstrated the use of singular value decomposition to enhance hemorrhage detection and validated the system's performance on phantoms and in vivo animal tumor models. This PACT-HIFU system is expected to have practical applications in oncology research using small animal models.
BIOMEDICAL OPTICS EXPRESS
(2021)
Review
Biotechnology & Applied Microbiology
Tingting Hu, Zhou Qin, Chao Shen, Han-Lin Gong, Zhi-Yao He
Summary: Mitochondria play crucial roles in cancer cells, and precise delivery of anticancer agents to mitochondria can be a novel strategy for enhanced cancer treatment. Overcoming the challenge of mitochondrial negative potential preventing molecules from reaching them, advancements in nanosystems such as liposomes, nanoparticles, and nanomicelles provide hope for targeted drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alison Domingues, Alessandro Fantin
Summary: The vascular endothelium acts as a selective barrier to regulate macromolecule exchange, but its integrity is compromised in various pathological conditions, leading to increased vascular hyperpermeability. VEGFA is a potent permeability factor, and NRP1 may play a fundamental role in regulating VEGFA-induced responses in vascular endothelial cells.
Article
Materials Science, Biomaterials
Chunmei Wang, Zhifang Li, Jianwen Bai
Summary: High intensity focused ultrasound (HIFU) is a promising cancer treatment mode due to its minimal invasiveness and irradiation-free nature. However, its therapeutic potency is relatively low, limiting its clinical application. In this study, CaO2@SiO2 nanoparticles were developed to enhance the efficacy of HIFU surgery against tumors. These nanoparticles can release O-2 and H2O2, improving US imaging signals and the potency of HIFU surgery. Furthermore, local temperature increase during HIFU treatment can trigger O-2 generation, further enhancing the efficacy of HIFU treatment.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biochemistry & Molecular Biology
Max L. B. Gronloh, Janine J. G. Arts, Sebastian Palacios Martinez, Amerens A. van Der Veen, Lanette Kempers, Abraham C. van Steen, Joris J. T. H. Roelofs, Martijn A. Nolte, Joachim Goedhart, Jaap D. van Buul
Summary: Using a photoconvertible probe, researchers traced and identified the original endothelial transmigration hotspots, and found that these hotspots function to limit vascular leakage during transmigration events. The distribution of ICAM-1 determines the location of the transmigration hotspot.
Review
Cell Biology
Jan K. Hennigs, Christiane Matuszcak, Martin Trepel, Jakob Koerbelin
Summary: Endothelial cells play crucial roles in facilitating physiological processes throughout the body, demonstrating tremendous cellular diversity. Different endothelial cell populations adapt to the specific needs of various organs and tissues, influencing vascular tone, blood coagulation, and cellular adhesion.
Article
Materials Science, Biomaterials
Dhiraj Kumar, Mahdieh Moghiseh, Kenny Chitcholtan, Isha Mutreja, Chiara Lowe, Ajeet Kaushik, Anthony Butler, Peter Sykes, Nigel Anderson, Aamir Raja
Summary: Emerging multifunctional nanoparticulate formulations, with nano-meter scale size and surface chemistry, can act as therapeutic delivery agents and diagnostic tools for non-invasive real-time monitoring using imaging technologies. This study evaluated the selective uptake of 18 nm and 80 nm sized gold nanoparticles (AuNPs) by ovarian cancer (OC) cells in vitro, and found that the 18 nm AuNPs were taken up 4 times more by SKOV3 cells compared to OVCAR5 cells. Luteinizing hormone-releasing hormone (LHRH) was conjugated to the surface of the AuNPs, making them potential contrast agents for novel spectral photon-counting CT imaging technology and a promising approach for targeted therapy of ovarian cancer.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Pharmacology & Pharmacy
Nicola Ingram, Laura E. McVeigh, Radwa H. Abou-Saleh, Damien V. B. Batchelor, Paul M. Loadman, James R. McLaughlan, Alexander F. Markham, Stephen D. Evans, P. Louise Coletta
Summary: Advanced drug delivery systems, such as ultrasound-mediated drug delivery, have the potential to increase the therapeutic index. This study investigates the effect of altering ultrasound parameters on drug delivery and finds that a short tone burst provides the best parameters for tumoral drug delivery.
Article
Engineering, Biomedical
Jingyi Sheng, Yang Liu, He Ding, Linyuan Wu, Lan Liu, Guangxiang Si, Yan Shen, Fang Yang, Ning Gu
Summary: This study demonstrates the potential of magnetic targeting as an effective strategy for delivering cancer vaccines and activating the immune response. By targeting antigen-loaded magnetic liposomes to the lymph nodes, the population of active dendritic cells and cytotoxic T lymphocytes is increased, resulting in effective tumor growth inhibition.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Lillie O'steen, Robert J. Amdur, Christopher G. Morris, Kathryn E. Hitchcock, William M. Mendenhall
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2019)
Article
Otorhinolaryngology
William M. Mendenhall, Christopher G. Morris, Robert J. Amdur, Kathryn E. Hitchcock, Natalie L. Silver, Peter T. Dziegielewski
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Otorhinolaryngology
Peter T. Dziegielewski, Stewart Bernard, William M. Mendenhall, Kathryn E. Hitchock, Charles Parker Gibbs, Joy Wang, Robert J. Amdur, Natalie L. Silver, John Hardeman, Hadi Seikaly, William J. Reschly, Deepa Danan, Raja Sawhney
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Otorhinolaryngology
James E. Bates, Kathryn E. Hitchcock, William M. Mendenhall, Peter T. Dziegielewski, Robert J. Amdur
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Oncology
Robert J. Amdur, Roi Dagan, Adam Holtzman, Anamaria R. Yeung, Kathryn E. Hitchcock, William M. Mendenhall
Article
Otorhinolaryngology
William M. Mendenhall, Christopher G. Morris, Robert J. Amdur, Kathryn E. Hitchcock, Neil Cheddha, Peter T. Dziegielewski
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Editorial Material
Oncology
Kathryn E. Hitchcock
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Otorhinolaryngology
Emma J. Djabali, Jason Rotter, Neil N. Chheda, Robert J. Amdur, Kathryn Hitchcock, William Mendenhall, Peter T. Dziegielewski
Summary: The study suggests that wood hardness classification may be useful in predicting pharyngoesophageal stricture formation in salvage laryngectomy patients, providing potential for implementing preventive measures. The negative association between wood hardness and stricture development was consistent, with some analyses showing statistical significance in certain scenarios.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Article
Physiology
Amy Fullerton, Yuhan Mou, Natalie Silver, Neil N. Chheda, Kathryn Hitchcock, Karen Hegland
Summary: The study found reduced airflow during reflexive cough in advanced stage head and neck cancer survivors, with even lower airflow in aspirators. Surprisingly, patients recently post-treatment showed worse cough airflow compared to those further post-treatment.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Otorhinolaryngology
Alexandra N. de Leo, Roi Dagan, Christopher G. Morris, Adam L. Holtzman, Kathryn E. Hitchcock, Curtis M. Bryant, Robert J. Amdur, William M. Mendenhall
Summary: This study assessed the outcomes of radiotherapy in patients with T2 and select T3 glottic SCC. The addition of concurrent platinum-based chemotherapy to radiotherapy appeared to be safe and worthy of further investigation in patients with impaired cord mobility.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Acoustics
Robert T. Kleven, Shenwen Huang, Samantha M. Ford, Karthikeyan Sakthivel, Seth R. Thomas, Mario Zuccarello, Andrew B. Herr, Christy K. Holland
Summary: Transcranial ultrasound exposure was hypothesized to improve thrombolysis for intracerebral hemorrhage (ICH). However, the study found no enhancement of rt-PA-induced thrombolysis with the addition of ultrasound, likely due to the lack of exogenous cavitation nuclei. This research has important implications for surgical intervention in ICH.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Acoustics
Kevin J. J. Haworth, Nuria Gonzales Salido, Maxime Lafond, Daniel Suarez Escudero, Christy K. K. Holland
Summary: Data-adaptive spatial filtering improves the performance of passive cavitation imaging (PCI) beamforming, enhancing source localization and image quality while reducing computation time.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Acoustics
Daniel Suarez Escudero, Kevin J. Haworth, Curtis Genstler, Christy K. Holland
Summary: The objective of this study was to quantify the spatial and temporal distribution of cavitation activity induced by Definity infused through the EKOS catheter. Different acoustic parameters were found to have a significant impact on the energy, location, and duration of cavitation activity. A cavitation dose metric based on energy density was used to measure the influence of different acoustic parameters on cavitation activity.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ibrahim Nassour, Austin Parrish, Lucy Baptist, Sarah Voskamp, Komal Handoo, Sherise Rogers, Jesus Fabregas, Thomas George, Kathryn Hitchcock, Alessandro Paniccia, Steven Hughes
Summary: The use of neoadjuvant systemic therapy in the treatment of pancreatic cancer has surpassed the traditional standard of upfront surgery followed by adjuvant therapy, indicating a national shift in clinical management of the disease.
Review
Dentistry, Oral Surgery & Medicine
William M. Mendenhall, Adam L. Holtzman, Roi Dagan, Curtis M. Bryant, Kathryn E. Hitchcock, Robert J. Amdur, Rui P. Fernandes
Summary: The primary role of radiotherapy in the management of oral cavity SCC is in the postoperative setting, with palliative radiotherapy being reserved for patients with very advanced disease. The likelihood of cure varies depending on the extent of disease, and treatment may include surgery, radiotherapy, chemotherapy, or supportive care.
CRANIOMAXILLOFACIAL TRAUMA & RECONSTRUCTION
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)