Microfluidic controlling monodisperse microdroplet for 5-fluorouracil loaded genipin-gelatin microcapsules

This paper demonstrates a proof-of-concept approach for producing genipin-gelatin microcapsules of precisely controlled and monodisperse size distributions by the microfluidic channels. We have demonstrated that one could control the size of emulsions from 130 mu m to 580 mu m in diameter (with a variation of less than 5%) by altering the relative sheath/sample flow rate ratio. In addition, Results show that the encapsulation and in vitro release of a model drug. 5-fluorouracil, to enhance the effect of controlled release. We demonstrated that the appropriate particle size for different release patterns is predictable, enabling better application of genipin-gelatin microcapsules as a drug carrier. The proposed microfluiclic chip better a bli pp ng ena is capable of generating relatively uniform micro-droplets with well controllable diameter, and it has the added advantages of being a simple, low cost, and high throughput process. Crown Copyright (c) 2009 Published by Elsevier B.V. All rights reserved.