Article
Environmental Sciences
Xian Wen Sun, Ying Ni Lin, Yong Jie Ding, Shi Qi Li, Hong Peng Li, Jian Ping Zhou, Liu Zhang, Ji Min Shen, Qing Yun Li
Summary: Epidemiologic studies have shown that PM2.5 exacerbates chronic airway inflammation and Surfaxin can protect the alveolar epithelium from PM2.5 in airway inflammation through increasing SPs levels.
ENVIRONMENTAL RESEARCH
(2022)
Article
Cell Biology
Takae Tanosaki, Yu Mikami, Hideo Shindou, Tomoyuki Suzuki, Tomomi Hashidate-Yoshida, Keisuke Hosoki, Shizuko Kagawa, Jun Miyata, Hiroki Kabata, Katsunori Masaki, Ryuji Hamamoto, Hidenori Kage, Naoya Miyashita, Kosuke Makita, Hirotaka Matsuzaki, Yusuke Suzuki, Akihisa Mitani, Takahide Nagase, Takao Shimizu, Koichi Fukunaga
Summary: This study investigated the role of LPCAT1 in the pathology of COPD. The findings showed that mice with Lpcat1 gene knockout had significantly worsened elastase-induced emphysema, which was not improved by supplementing with surfactant that is mainly synthesized by LPCAT1. Additionally, cigarette smoke extract was found to downregulate the expression of LPCAT1 in human lung cells and induce apoptosis. These results suggest that the downregulation of LPCAT1 by cigarette smoke may contribute to the exacerbation of pulmonary emphysema through increasing the susceptibility of alveolar epithelial cells to apoptosis, highlighting LPCAT1 as a potential therapeutic target for irreversible emphysema.
Article
Pharmacology & Pharmacy
Leonidas Gkionis, Harmesh Aojula, Lynda K. Harris, Annalisa Tirella
Summary: Microfluidics technology enables precise control over the continuous mixing of fluid phases at the micrometre scale, aiming to optimize processing parameters and facilitate scale-up feasibility. This study successfully utilized microfluidics to rapidly screen manufacturing parameters and phosphatidylcholine formulations to obtain monodispersed and stable liposomal formulations with a narrow size distribution, which showed sustained release of doxorubicin. The drug release profiles varied as a function of DMPC/DSPC mol content in the lipid bilayer, with DMPC-based liposomes exhibiting sustained release compared to DSPC liposomes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Chanhee Oh, Ok Hwa Jeon, Junhee Han, Kyungsu Kim, Hyun Koo Kim, Ji-Ho Park
Summary: Inhalable nanotherapeutics using exogenous pulmonary surfactant (PS) were developed to treat lung adenocarcinoma, showing selective interaction with adenocarcinoma cells in vitro and prolonged retention in the alveolar space after inhalation. Inhalation treatments with paclitaxel-loaded PSNVs significantly inhibited tumor growth in a lung cancer mouse model compared to free paclitaxel and synthetic NVs, suggesting great potential for treating lung adenocarcinoma.
ACS APPLIED NANO MATERIALS
(2023)
Article
Medicine, Research & Experimental
Olivia Amanda Oest Mullertz, Peter Andersen, Dennis Christensen, Camilla Foged, Aneesh Thakur
Summary: The mucosal surfaces of the lungs are a major site for entry of airborne pathogens and pulmonary vaccination can induce protective mucosal immunity. Researchers found that altering the surface charge of liposomes can enhance specific T-cell responses, but the impact on mucosal immunity remains unclear.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Domizia Baldassi, Thi My Hanh Ngo, Olivia M. Merkel
Summary: This study aimed to investigate how coating with a pulmonary surfactant affects the physicochemical parameters and in vitro behavior of polyethylenimine (PEI) polyplexes for pulmonary siRNA delivery. The results showed that the coating improved the internalization and gene silencing efficiency of the polyplexes in lung epithelial cells. Furthermore, the optimal coating ratio was identified to achieve diffusion through the mucus layer while retaining gene silencing activity in a 3D air-liquid interface culture model. This study highlights the importance of pulmonary surfactant coating in improving local siRNA delivery to the lungs.
PHARMACEUTICAL RESEARCH
(2022)
Article
Instruments & Instrumentation
Shruti S. Sawant, Suyash M. Patil, Snehal K. Shukla, Nishant S. Kulkarni, Vivek Gupta, Nitesh K. Kunda
Summary: Inhalable OB liposomes were developed to limit systemic toxicity and locally accumulate at tumor sites. Active loading of OB into liposomes resulted in higher cytotoxicity and potential for inhibiting lung cancer growth compared to passive loading methods.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Mojtaba Falahati, Anwarul Hasan, Hojjat Alizadeh Zeinabad, Vahid Serpooshan, J. H. von der Thusen, Timo L. M. ten Hagen
Summary: This review explores the interaction between inhaled nanoparticles (NPs) and pulmonary surfactant (PSf), and discusses the engineering of PSf in the lung environment. It provides valuable insights into the role of biofluids in the cellular uptake of NPs and their nanotoxic effects.
Article
Chemistry, Multidisciplinary
Dongjun Li, Ang Zhao, Jiafei Zhu, Chunjie Wang, Jingjing Shen, Zixuan Zheng, Feng Pan, Zhuang Liu, Qian Chen, Yang Yang
Summary: By evaluating the sustainability of various components, researchers found that neutral liposomes are suitable for delivering metformin and nintedanib for pulmonary fibrosis treatment. Moreover, repeated noninvasive aerosol inhalation of metformin and nintedanib loaded liposomes can effectively reduce fibrosis development and improve lung function.
Article
Biophysics
Olga Canadas, Alejandra Saenz, Alba de Lorenzo, Cristina Casals
Summary: This study reveals that β-D-glucan inhibits the biophysical function of pulmonary surfactant by extracting phospholipid molecules from surfactant membranes, resulting in increased membrane fluidity and reduced surface tension. Surfactant preparations containing surfactant protein A (SP-A) are more resistant to β-D-glucan inhibition. These findings enhance the potential use of SP-A in surfactant replacement therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Tiffany Guitton-Spassky, Florian Junge, Abhishek Kumar Singh, Boris Schade, Katharina Achazi, Marta Maglione, Stephan Sigrist, Rashmi Rashmi, Rainer Haag
Summary: Enzymes are more selective and efficient than synthetic catalysts, but difficult to recycle. This can be overcome by immobilization, specifically through encapsulation. Fluorinated dendritic amphiphiles have been found to self-assemble into perforated bilayer vesicles, known as stomatosomes, which show increased porosity while retaining larger biomolecules.
Article
Engineering, Biomedical
Pranav Ponkshe, Sheng Feng, Chalet Tan
Summary: Inhalation delivery of liposomal drugs offers advantages for treating pulmonary diseases, with several inhalable liposomes currently in clinical trials for various indications in the lungs. This review discusses the general principles of pulmonary delivery and the clinical development of inhalable liposomal drugs.
BIOMEDICAL MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Zhimei Xiao, Bo Zhuang, Guoli Zhang, Miao Li, Yiguang Jin
Summary: This study explored the combination of cationic liposomal hydroxycamptothecin (CLH) and 5-aminolevulinic acid (5-ALA) for chemo-sonodynamic therapy (Chemo-SDT) of metastatic lung cancer via intratracheal administration. The results demonstrated that this combination showed higher anticancer efficacy by enhancing cancer cell apoptosis and reactive oxygen species production.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Ipek Sahin, Cagatay Ceylan, Oguz Bayraktar
Summary: Ruscogenin, a steroid saponin, has significant effects on the phase transition, order, dynamics, and hydration state of model membranes. It disordered the zwitterionic model membrane but increased the order of the charged model membrane.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Pharmacology & Pharmacy
Cristina Loira-Pastoriza, Kevin Vanvarenberg, Bernard Ucakar, Maria Machado Franco, Aurelie Staub, Muriel Lemaire, Jean-Christophe Renauld, Rita Vanbever
Summary: Immunotherapy using immunostimulatory agents delivered intratumorally has shown promising efficacy in the treatment of lung cancer. Encapsulation of unmethylated oligodeoxynucleotides containing CpG motifs (CpG) and polyinosinic-polycytidylic acid (poly I:C) double-stranded RNA in liposomes can enhance their antitumor activity by increasing uptake by lung phagocytes and activating toll-like receptors. CpG encapsulation in DOTAP/DPPC liposomes significantly enhances its antitumor effects in lung cancer by inducing immune responses and delaying tumor growth.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
