Article
Pharmacology & Pharmacy
Runqiao Dong, J. Axel Zeitler
Summary: The dissolution of coated pharmaceutical tablets is a complex process that depends on the structure of the coating and its interaction with the tablet core. This study used terahertz pulsed imaging to investigate the penetration of the dissolution medium into coated tablets. The analysis revealed a discontinuity in density at the interface between the coating and core, which affected the liquid transport and dissolution performance. The study provides insights into the role of coating in tablet dissolution.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Runqiao Dong, Marwa Nassar, Barry Friend, Jason Teckoe, J. Axel Zeitler
Summary: Coated tablets introduce complexity to the dissolution process, even with readily soluble immediate release coating layers. The current study uses terahertz pulsed imaging to visualise the hydration process of microcrystalline cellulose (MCC) tablet cores that were film coated with an immediate release coating formulation upon exposure to the dissolution medium. The penetration rate through the coating layer and the tablet core both strongly depended on coating thickness and core porosity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Moritz Anuschek, Thomas Kvistgaard Vilhelmsen, J. Axel Zeitler, Jukka Rantanen
Summary: Traditional methods for quality control of pharmaceutical tablets are time-consuming and resource-consuming, and not suitable for continuous manufacturing. Terahertz time-domain spectroscopy reflection measurements offer a fast and non-destructive approach to measure tablet porosity, height, and mass, providing an opportunity to determine the tablet's mechanical strength.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Celine van Haaren, Marieke De Bock, Sergei G. G. Kazarian
Summary: One of the major challenges in developing oral pharmaceutical formulations is the poor solubility of active ingredients. Standard dissolution tests provide limited information, but ATR-FTIR spectroscopic imaging offers high spatial and chemical specificity to study tablet dissolution processes. Understanding these mechanisms is crucial for effective formulation development.
Article
Engineering, Chemical
Lars Pasternak, Martin Sommerfeld, Pradeep Muramulla, Fei-Liang Yuan, Srikanth Gopireddy, Nora Urbanetz, Thomas Profitlich
Summary: In the pharmaceutical industry, coating of granulates or tablets is a crucial production step. Numerical simulation of the tablet coating process allows prediction of coating results without time-consuming lab-scale experiments. Knowledge of spray droplet properties and measurements using Phase Doppler Anemometry (PDA) are essential for successful simulation. The measurements provided valuable data on droplet size and velocity distributions in different spray cross-sections.
Article
Pharmacology & Pharmacy
Qi Zeng, Xin Gao, Long Wang, Guangpu Fang, Jiahe Qian, Hai Liu, Zheng Li, Wenlong Li
Summary: This study investigated the minimum Raman mapping area required for predicting sustained-release tablet dissolution profiles based on intra-tablet homogeneity. The sample set was constructed by controlling the blending time to introduce variability in tablet homogeneity. Dissolution prediction models were established using partial least squares regression under different mapping areas. The accuracy of the prediction results was evaluated and the implications were discussed. The results showed that tablet homogeneity affects the minimum required mapping area, and tablets with higher homogeneity exhibit higher prediction accuracy using the same mapping area.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ningyun Sun, Liang Chang, Yi Lu, Wei Wu
Summary: The study used Raman mapping-based reverse engineering to analyze the critical attributes of nifedipine formulation, finding that particle size plays a crucial role in release pattern and bioavailability. Tablets with a particle size comparable to a commercial product showed similar in vitro release profiles and bioequivalence to the reference listed drug.
Article
Pharmacology & Pharmacy
Lian Shen, Xiaohong Yu, Hui Fu, Sainan Wei, Weiguang Shan, Yan Yang
Summary: Capsules were coated using two thermoforming coating techniques, VFC and CFC, with VFC process being more suitable for lower temperature. Drug release rate decreased with increasing film thickness, and the optimal coatings exhibited sustained-release properties.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Dorian Laszlo Galata, Boldizsar Zrisos, Gabor Knyihar, Orsolya Peterfi, Lilla Alexandra Meszaros, Ferenc Ronkay, Brigitta Nagy, Edina Szabo, Zsombor Kristof Nagy, Attila Farkas
Summary: In this work, a state-of-the-art fast Raman imaging apparatus is used to determine the concentration and particle size of HPMC in sustained release tablets and predict their dissolution profile. Convolutional neural networks (CNNs) are employed for the first time to process chemical images and directly predict the dissolution profile. The CNN shows the ability to recognize patterns in the data and provides detailed information for better understanding of the manufacturing processes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Hao Lou, Michael J. Hageman
Summary: Computational fluid dynamics methods were used to investigate the influence of tablet location on polymer erosion and drug release of surface-erodible sustained-release tablets. The results showed that tablet deformation was faster at off-center positions, but had minimal impact on drug release rate, indicating the reliability of the USP apparatus II for dissolution testing of such tablets.
Article
Pharmacology & Pharmacy
Brigitta Nagy, Agnes Szabados-Nacsa, Gergo Fulop, Aniko Turak Nagyne, Dorian Laszlo Galata, Attila Farkas, Lilla Alexandra Meszaros, Zsombor Kristof Nagy, Gyorgy Marosi
Summary: As the pharmaceutical industry adopts Pharma 4.0, there is a need to predict product quality based on manufacturing or in-process data. Artificial neural networks (ANNs) were developed and interpreted to increase process understanding by analyzing developmental or manufacturing data. The ANNs provided better results for predicting tablet dissolution and hardness compared to NIR or Raman spectra. They were also used to identify the root causes of batch-to-batch variability and control the tableting process.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Engineering, Chemical
Jiandong Zuo, Biqin Dong, Feng Xing, Chaoyun Luo, Jia Zhan, Lei Wang
Summary: Corrosion inhibitor microcapsules prepared by centrifugation-coating method showed excellent surface morphology, thermal stability, and mechanical properties, with thicker walls obtained at higher weight gain rates of wall material leading to slower release rates. Polymethyl methacrylate as wall material released drugs faster than ethyl cellulose in simulated concrete pore solution.
Article
Pharmacology & Pharmacy
Leo Picart, Vincent Mazel, Aline Moulin, Vanessa Bourgeaux, Pierre Tchoreloff
Summary: This study focuses on the influence of geometrical and process parameters on the release attributes of press-coated tablets, while maintaining a constant formulation. The results show that by adjusting compression pressure, layer thickness, and band thickness, the lag-time and release kinetics can be controlled, which is crucial for achieving delayed drug release.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Endocrinology & Metabolism
Li-xin Guo, Guo-en Liu, Li Chen, Hai-fang Wang, Jian Guo, Xian-ling Zheng, Bin-hong Duan, De-zhong Wang, Wei Zhu, Kun Wang, Wan-shou Tan, Qiu Chen, Quan-zhong Li, Jing Yang, Qiu Zhang, Pei-feng Xie, Min-xiang Lei
Summary: Metformin hydrochloride sustained-release (SR) tablet (II) produced by Dulening and the original metformin hydrochloride tablet produced by Glucophage exhibit similar therapeutic efficacy in the treatment of T2DM, but the Dulening group has a significantly lower overall incidence of ADRs as well as gastrointestinal ADR compared to the Glucophage group.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yaser Mansuroglu, Jennifer Dressman
Summary: Hot-melt extrusion is widely used in the pharmaceutical industry to increase the solubility of poorly soluble drugs. This study investigated the release of flurbiprofen from sustained-release hot-melt extrudates with different Eudragit polymers. The choice of polymer and particle size reduction by milling were found to be key factors influencing the release profile, while drug loading and hydrodynamics had minimal impact. Hot-melt extrusion allows for tailored drug release through particle size and polymer selection, with robustness under various hydrodynamic conditions.
Article
Pharmacology & Pharmacy
Yixuan Wang, Thomas Rades, Holger Grohganz
Summary: In this study, the composition evolution of the ternary co-amorphous system CAR-TRP-HPMC was investigated by adding HPMC to previously formed binary systems (CAR - TRP + HPMC, CAR - HPMC + TRP and TRP - HPMC + CAR) prepared by ball milling. The miscibility of CAR with TRP was reduced by the addition of HPMC, as hydrogen bonds formed between CAR and polymer. Phase separation and crystallization of CAR and TRP were observed when their solubility limit in HPMC was exceeded. All ternary co-amorphous systems eventually reached the same composition, but followed different paths depending on the initially used binary system.
Article
Pharmacology & Pharmacy
Xiaoyue Xu, Thomas Rades, Holger Grohganz
Summary: It has been observed that water, as a plasticizer, can increase molecular mobility and decrease the glass transition temperature (Tg) in amorphous systems. However, a recent study found an anti-plasticizing effect of water on prilocaine (PRL), which could be used to moderate the plasticizing effect of water in co-amorphous systems. Nicotinamide (NIC) can form co-amorphous systems with PRL. In this study, the Tgs and molecular mobility of hydrated co-amorphous NIC-PRL systems were compared with those of anhydrous systems to investigate the effect of water.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Katharina Holzapfel, Thomas Rades, Claudia S. Leopold
Summary: The influence of an enantiomeric co-former and the preparation method on the solid-state properties and physical stability of co-amorphous systems was investigated in this study. It was found that the chirality of the co-former and the preparation method had an impact on the solid-state properties and physical stability of the systems.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Editorial Material
Pharmacology & Pharmacy
Shyamal Das, Thomas Rades, Arlene McDowell
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Samuel J. Harris, C. John McAdam, Pawel Wagner, Joseph I. Mapley, Keith C. Gordon
Summary: The vibrational and electronic properties of six systematicallyaltered donor-acceptor dyes were investigated using DFT, spectroscopy, and electrochemical techniques. The results showed that the geometry of the dyes was planar with extended pi-systems. The absorption and emission spectra demonstrated pi-pi* and charge transfer transitions, respectively, and the emission behavior was influenced by the acceptor units.
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Materials Science, Textiles
Sophie A. Wilson, Raechel M. Laing, Eng Tan, Cheryl A. Wilson, P. Samanali Garagoda Arachchige, Keith C. Gordon, Sara J. Fraser-Miller
Summary: Creating a stable sensor using dipping and encapsulation processes on a knit fabric is feasible, but the deposition location is not well understood. Various characterization tools, such as microscopy and spectroscopy, were used to investigate the effects of two graphene treatments and three encapsulants on single jersey fabrics made of wool and cotton. Microscopic analysis showed that the fabric structure, yarns, and fibers remained largely unchanged, while Raman analysis was found to be a more preferable method for determining the chemical composition of the treatments compared to FTIR.
JOURNAL OF THE TEXTILE INSTITUTE
(2023)
Article
Instruments & Instrumentation
Mette Klitgaard, Maja Norgaard Kristensen, Ramakrishnan Venkatasubramanian, Priscila Guerra, Jette Jacobsen, Ragna Berthelsen, Thomas Rades, Anette Mullertz
Summary: This study aimed to improve the preclinical evaluation of new oral drug formulations by investigating the DSS-induced colitis model. Various parameters were evaluated, and the disease activity index, colon length, and histological evaluation of the colon were identified as effective indicators of colitis in rats. The study also found that the DSS-induced colitis affected luminal pH, lipase activity, and concentrations of bile salts, polar lipids, and neutral lipids.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Afnan Bany Odeh, Boushra El-Sayed, Matthias Manne Knopp, Thomas Rades, Lasse Ingerslev Blaabjerg
Summary: This study investigates the influence of PVP concentration and molecular weight on the precipitation inhibition of poorly soluble drugs, albendazole, ketoconazole, and tadalafil. The results showed that increasing the PVP concentration leads to a higher onset of nucleation and a lower precipitation rate, while the medium viscosity has no significant effect on the nucleation and precipitation rate.
Article
Pharmacology & Pharmacy
Peter I. I. I. J. G. Remoto, Karlis Berzins, Sara J. Fraser-Miller, Timothy M. Korter, Thomas Rades, Jukka Rantanen, Keith C. Gordon
Summary: The solid-state landscape of carbamazepine during dehydration was investigated using both low- (-300 to -15, 15 to 300 cm(-1)) and mid- (300 to 1800 cm(-1)) frequency Raman spectroscopy. Density functional theory with periodic boundary conditions was employed to characterize the carbamazepine dihydrate and different forms, which showed good agreement with experimental Raman spectra. The dehydration process of carbamazepine dihydrate at various temperatures (40, 45, 50, 55, and 60 ?) was explored using principal component analysis and multivariate curve resolution, revealing different transformation pathways of solid-state forms. Low-frequency Raman spectroscopy was found to effectively detect the rapid growth and subsequent decline of carbamazepine form IV, which was not as well observed by mid-frequency Raman spectroscopy. These findings highlight the potential benefits of low-frequency Raman spectroscopy in pharmaceutical process monitoring and control.
Article
Chemistry, Multidisciplinary
Joshua Kirkham, Timothy M. Korter, Karlis Berzins, Cushla M. McGoverin, Keith C. Gordon, Sara J. Fraser-Miller
Summary: Low-frequency Raman spectroscopy and solid-state density functional theory were used to characterize variably substituted hydroxyapatites with Sr2+, F-, and CO3 (2-) as the substituting species in the crystalline and amorphous forms. The study demonstrated clear differences between amorphous and crystalline forms and systematic changes in the crystalline spectra with the level of substitution. A new crystallinity index (CI) based on low-frequency Raman intensities was proposed and showed better correlation with the XRPD-based CI compared to previous methods.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Pharmacology & Pharmacy
Jacob Rune Jorgensen, Wolfgang Mohr, Matthias Rischer, Andreas Sauer, Shilpa Mistry, Thomas Rades, Anette Muellertz
Summary: The use of amorphous solid dispersions (ASDs) is a commonly applied formulation strategy to improve the oral bioavailability of poorly water-soluble drugs. However, establishing a predictive model for the in vitro-in vivo relationship (IVIVR) has been challenging. This study suggests that drug absorption may be overestimated in in vitro dissolution-permeation (D/P) setups, and proposes a modified D/P setup to improve predictability by avoiding direct dissolution of drug particles in the permeation barrier.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Joseph I. Mapley, Jordan N. Smith, Georgina E. Shillito, Sara J. Fraser-Miller, Nigel T. Lucas, Keith C. Gordon
Summary: Spectroscopy was used to study the excited states of chromophore-connected HBC-dppz complexes with rhenium(I) and ruthenium(II). The HBC-substituted dppz ligand and its corresponding complexes were synthesized and characterized. The interplay of their excited states and the perturbation of the HBC were investigated. These studies provide insight into the design of polyaromatic systems and contribute to the knowledge of dppz systems.
INORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Mengwei Wang, Junbo Gong, Thomas Rades, Ines C. B. Martins
Summary: Ball milling can reduce the particle size of pharmaceutical powders and induce changes in their physical properties. In this study, we prepared three crystal forms of furosemide and used X-ray diffraction and modulated differential scanning calorimetry to characterize the samples. We found that forms I and III directly converted into an amorphous phase, while form II first underwent a polymorphic transition to form I and then gradually lost its crystallinity. The structural relaxation time of the amorphous fraction was longer for forms I and II, while it was shorter for form III, indicating an amorphous-to-amorphous transformation phenomenon.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Yuehua Deng, Shiyuan Liu, Yanbin Jiang, Ines C. B. Martins, Thomas Rades
Summary: Multicomponent solid forms can enhance the properties of low molecular weight drugs, but predicting their formation in the early stages of formulation development is challenging. Empirical and computational methods have been developed, with artificial intelligence being the latest research focus.
Article
Chemistry, Multidisciplinary
Ines C. B. Martins, Anders S. Larsen, Anders O. Madsen, Olivia Aalling Frederiksen, Alexandra Correia, Kirsten M. O. Jensen, Henrik S. Jeppesen, Thomas Rades
Summary: Polyamorphism is a controversial solid-state phenomenon that is still not fully understood. In this study, three distinct polyamorphic forms of hydrochlorothiazide were discovered and their interconversions were investigated. Molecular dynamics simulations revealed differences in dihedral angle distributions between two of the polyamorphs, which may explain their different physicochemical properties.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
