Review
Pharmacology & Pharmacy
Claudia Viegas, Ana B. Patricio, Joao M. Prata, Akhtar Nadhman, Pavan Kumar Chintamaneni, Pedro Fonte
Summary: Solid-lipid nanoparticles and nanostructured lipid carriers are delivery systems that enhance drug solubility, permeability, and bioavailability. The use of liquid and solid lipids in nanostructured lipid carriers allows for higher drug loading, improved drug release properties, and increased stability. This review discusses the production methods, characterization, and performance of solid lipid nanoparticles and nanostructured lipid carriers, and also addresses the toxicity concerns.
Article
Pharmacology & Pharmacy
Marianna Araujo Ferreira, Renato Ferreira de Almeida Junior, Thiago Souza Onofre, Bruna Renata Casadei, Kleber Juvenal Silva Farias, Patricia Severino, Camilo Flamarion de Oliveira Franco, Fernanda Nervo Raffin, Tulio Flavio Accioly Moura, Raquel de Melo Barbosa
Summary: Annatto, widely used as a food pigment, has been found to possess healing and antioxidant properties, as well as effectiveness against leishmaniasis. Incorporating the oil from annatto seeds into a nanostructured lipid carrier (NLC) showed promising results in terms of physicochemical properties and biological activity against Leishmania major, indicating its potential as a therapeutic agent.
Article
Chemistry, Multidisciplinary
A. Sofia Pinho, Catarina L. Seabra, Claudia Nunes, Salette Reis, M. Cristina Martins, Paula Parreira
Summary: Bacterial biofilms, including those formed by Helicobacter pylori, are highly resistant to antibiotics. This study found that nanostructured lipid carriers (NLC) can effectively reduce biofilm biomass and kill both biofilm and planktonic bacteria of H. pylori. Additionally, the combination of docosahexaenoic acid (DHA) and NLC showed a synergistic effect in treating H. pylori biofilms.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Florina Veider, Zeynep Burcu Akkus-Dagdeviren, Patrick Knoll, Andreas Bernkop-Schnuerch
Summary: In this study, PEG-free and zeta potential changing lipid-based nanocarriers were developed to enhance cellular uptake. The results showed that the nanocarriers released phosphate under intestinal alkaline conditions through polyphosphate coating, resulting in significant zeta potential changes and improved cellular uptake.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Physical
Anna Czajkowska-Kosnik, Emilia Szymanska, Robert Czarnomysy, Julia Jacyna, Michal Markuszewski, Anna Basa, Katarzyna Winnicka
Summary: The study focused on using Nanostructured lipid carriers (NLC) as carriers for Etodolac, optimizing their composition and properties, providing a safe and effective approach for dermal delivery.
Article
Pharmacology & Pharmacy
Rute Chitas, Claudia Nunes, Salette Reis, Paula Parreira, Maria Cristina L. Martins
Summary: Chronic infection with Helicobacter pylori is a major risk factor for gastric cancer. Blank nanostructured lipid carriers (NLC) have shown potential for H. pylori eradication. Anionic NLC proved to be effective in completely clearing both rod and coccoid morphologies of H. pylori.
Article
Pharmacology & Pharmacy
Amira Motawea, Walaa Ebrahim Abd El Hady, Ghada Ahmed El-Emam
Summary: Nanoparticles were designed to improve the protective effects of trimebutine maleate (TMB) in ulcerative colitis. Nanostructured lipid carriers (NLC) of TMB were prepared using hot homogenization and ultra-sonication method. A factorial design was used to study the impact of different factors on particle size, polydispersity index, and entrapment efficiency. The optimized formula showed controlled release and alleviated the severity of colitis in rats. This research aimed to provide superior drug safety profile for the treatment of acute colitis.
Article
Pharmacology & Pharmacy
Hoda Atapour-Mashhad, Mojgan Nejabat, Farzin Hadizadeh, Afsaneh Hoseinsalari, Shiva Golmohammadzadeh
Summary: This study investigated the effect of solid lipids and surfactant type on the physical characteristics of Q10-NLC and found the optimum formulation for producing stable NLC with high entrapment efficiency. Atomistic M.D. simulations confirmed the stability of the best formulation.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Pharmacology & Pharmacy
Shang-Wen Lin, Yan-Jye Shyong, Ping-Chung Kuo, Jui-Chen Tsai
Summary: Sebacoyl dinalbuphine ester (SDE) is a prodrug of nalbuphine (NA) that can prolong the duration of NA in vivo, maximizing its efficacy in pain and pruritus management. The study successfully encapsulated SDE into NLC, improving its stability and enhancing skin penetration through hair follicles for sustained release during pruritus management. The topical application of SDE-NLCs significantly reduced scratching in pruritus-induced mice, demonstrating the potential for improving the quality of life for patients with chronic pruritus.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Sebastian Scioli-Montoto, Maria Laura Sbaraglini, Jose Sebastian Cisneros, Cecilia Yamil Chain, Valeria Ferretti, Ignacio Esteban Leon, Vera Alejandra Alvarez, Guillermo Raul Castro, German Abel Islan, Alan Talevi, Maria Esperanza Ruiz
Summary: This study developed an optimized nanostructured lipid carrier (NLC) containing the antiepileptic drug phenobarbital. The optimized formulation resulted in the delivery of the drug to the site of action in an adequate amount and time for therapeutic effects, without neurotoxicity.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Veerawat Teeranachaideekul, Putita Boribalnukul, Boontida Morakul, Varaporn Buraphacheep Junyaprasert
Summary: The study revealed that different types and content of oil had an impact on the chemical stability and release of lutein, with NLC and NE prepared from coconut oil showing higher release but those prepared from rice bran oil exhibiting better penetration through the skin.
Article
Biochemistry & Molecular Biology
Anna Czajkowska-Kosnik, Emilia Szymanska, Katarzyna Winnicka
Summary: In this study, nanostructured lipid carrier (NLC) gels containing etodolac (ETD) were developed for topical drug delivery. The gels exhibited favorable drug release and permeation properties, as well as stability, as confirmed by tests on pH, viscosity, rheological, mechanical, and bioadhesive properties.
Article
Pharmacology & Pharmacy
Shahram Mozaffar, Mohsen Radi, Sedigheh Amiri, David Julian McClements
Summary: A new approach of creating spray-dried NLCs by mixing them with salt prior to dehydration was developed in this study. Powders obtained contained particles with different dimensions, morphologies, and aggregation states. The particle sizes of the NLCs increased after redispersion of the spray-dried powders in water, but the mean diameters were still relatively low, indicating good flowability of the samples.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Claudia Pina Costa, Joao Nuno Moreira, Jose Manuel Sousa Lobo, Ana Catarina Silva
Summary: The management of CNS disorders is challenging due to the need for drugs to cross the BBB and reach the brain. Using the intranasal route combined with lipid-based nanocarriers has shown promising results in targeting drugs to the brain. Although the exact mechanism remains unclear, these systems are more effective than other routes and are expected to be approved by regulatory authorities in the future.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Pharmacology & Pharmacy
Sushrut Marathe, Gauri Shadambikar, Tabish Mehraj, Suresh P. Sulochana, Narendar Dudhipala, Soumyajit Majumdar
Summary: This study aimed to develop PTX-loaded NLCs to improve ocular bioavailability, with formulations demonstrating desirable physicochemical properties and stability under refrigerated conditions.
Correction
Polymer Science
Sajan Jose, Thomas A. A. Cinu, Rosmy Sebastian, M. H. Shoja, N. A. Aleykutty, Alessandra Durazzo, Massimo Lucarini, Antonello Santini, Eliana B. B. Souto
Review
Pharmacology & Pharmacy
Amanda Cano, Alvaro Munoz-Morales, Elena Sanchez-Lopez, Miren Ettcheto, Eliana B. Souto, Antonio Camins, Merce Boada, Agustin Ruiz
Summary: Neurodegenerative diseases have unknown etiology in many cases and lack effective treatments. The blood-brain barrier poses a challenge for drug delivery. Exosomes, secreted vesicles, have emerged as promising therapeutic tools due to their natural origin and molecular similarities. They are particularly promising for targeting neurodegenerative diseases due to the difficulty of accessing the brain and the complexity of the diseases.
Article
Pharmacology & Pharmacy
Gerard Esteruelas, Eliana B. Souto, Marta Espina, Maria Luisa Garcia, Marta Switalska, Joanna Wietrzyk, Anna Gliszczynska, Elena Sanchez-Lopez
Summary: Cancer is a leading cause of death worldwide, but there is still a need for an effective treatment with minimal adverse effects. Diclofenac, a non-steroidal anti-inflammatory drug, has shown promise as an antitumoral agent, but its prolonged use can lead to adverse effects. In this study, biodegradable polymeric nanoparticles were used to deliver diclofenac in a controlled manner, resulting in prolonged release and demonstrating antitumoral effects without cytotoxicity to non-tumoral cells.
Article
Pharmacology & Pharmacy
Ruth M. Galindo-Camacho, Isabel Haro, Maria J. Gomara, Marta Espina, Joel Fonseca, Carlos Martins-Gomes, Antoni Camins, Amelia M. Silva, Maria L. Garcia, Eliana B. Souto
Summary: The biocompatibility of cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles was evaluated in Caco-2 cell lines, demonstrating non-cytotoxicity, while the anti-inflammatory activity of the nanoparticles was tested in RAW 264.7 cell lines. Freeze-drying with different cryoprotectants was performed to prevent particle aggregation and physical stress. An in-situ forming gel based on poloxamer 407 containing Licochalcone-A-loaded PLGA nanoparticles functionalized with B6 and Tet-1 was developed for ocular administration, providing viscoelasticity, suitable mechanical properties, and mucoadhesive performance.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Audrey R. S. T. Silva, Amanda M. B. Costa, Sona Jain, Patricia Severino, Ricardo Scher, Rogeria S. Nunes, Eliana B. Souto, Silvio S. Dolabella
Summary: Leishmaniases are parasitic diseases that need cheaper, safer, and more effective treatment options. The anti-fungal compound 3carene (3CR) has potential as a treatment for Leishmania, but its hydrophobicity limits therapeutic uses. In this study, micellar systems made from poloxamers were developed to carry 3CR and enhance its activity against Leishmania braziliensis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Zielinska, Raquel da Ana, Joel Fonseca, Milena Szalata, Karolina Wielgus, Faezeh Fathi, M. Beatriz P. P. Oliveira, Rafal Staszewski, Jacek Karczewski, Eliana B. Souto
Summary: Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC) were used to encapsulate CBD, and their physicochemical characteristics were investigated. The results showed that CBD-loaded SLN had a mean particle size of 217.2 +/- 6.5 nm, PDI of 0.273 +/- 0.023, and EE of about 74%, while CBD-loaded NLC had Z-Ave of 158.3 +/- 6.6 nm, PDI of 0.325 +/- 0.016, and EE of about 70%. Rheological analysis indicated that both lipid nanoparticle formulations exhibited more elasticity than viscosity. SEM study confirmed the morphology and shape of the nanoparticles.
Article
Pharmacology & Pharmacy
Ian M. R. Blanco, Raquel de Melo Barbosa, Julita M. P. Borges, Silvio A. B. Vieira de Melo, Ramon dos Santos El-Bacha, Cesar Viseras, Patricia Severino, Elena Sanchez-Lopez, Eliana B. B. Souto, Elaine Cabral-Albuquerque
Summary: Traditional medicine uses resin oils from plants for medicinal purposes, and this study focuses on understanding their pharmacological properties. Liposomes containing resin oils or extracts from Copaifera sabulicola leaves were prepared and characterized. The liposomes showed cytotoxic effects against cancer cells and have potential applications in chemotherapy.
Review
Health Care Sciences & Services
Raquel da Ana, Anna Gliszczynska, Elena Sanchez-Lopez, Maria L. Garcia, Karolline Krambeck, Andjelka Kovacevic, Eliana B. Souto
Summary: Oxidation of lipids and lipoproteins contributes to inflammation processes that promote the development of eye diseases. Targeting lipid metabolism to treat ocular diseases is an interesting and effective approach.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Environmental Sciences
Sara A. Santos, Ricardo G. Amaral, Ariel S. Graca, Silvana V. F. Gomes, Fabricio P. Santana, Iza B. de Oliveira, Luciana N. Andrade, Patricia Severino, Ricardo L. C. de Albuquerque-Junior, Sandra L. Santos, Eliana B. Souto, Adriana A. Carvalho
Summary: The objective of this study was to evaluate the effects of combining the antineoplastic drug 5-fluorouracil (5-FU) with Matricaria recutita flowers extract (MRFE) to treat mice transplanted with sarcoma 180. The results showed that the combination of 5-FU and MRFE 200 mg/kg/day had a more significant tumor reduction compared to 5-FU alone. However, using MRFE 200 mg/kg/day may cause intense weight loss and splenic atrophy, but has minimal effects on cardiac and renal function. Therefore, the combination of 5-FU and MRFE 200 mg/kg/day may positively interfere with antitumor activity and reduce chemotherapy toxicity.
Review
Food Science & Technology
Beatriz N. Guedes, Faezeh Fathi, Amelia M. Silva, Antonello Santini, M. Beatriz P. P. Oliveira, Eliana B. Souto
Summary: Prickly pear, also known as Opuntia ficus-indica (OFI), is a beneficial plant with dietary fibers, vitamins and various bioactive compounds. This article reviews its nutritional composition, biological activities, and extraction techniques commonly used for different parts of the plant.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Cristina Galocha-Leon, Cristina Antich, Ana Voltes-Martinez, Juan A. Marchal, Mireia Mallandrich, Lyda Halbaut, Maria J. Rodriguez-Lagunas, Eliana B. Souto, Beatriz Clares-Naveros, Patricia Galvez-Martin
Summary: This study developed a hydrogel loaded with human mesenchymal stromal cells (hMSCs) for the treatment of superficial skin injuries. The hydrogel, using poloxamer 407 as a biomaterial, showed excellent physical, mechanical, morphological, and biological properties. It demonstrated high swelling capacity and did not affect the viability and healing capacity of keratinocytes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Aleksandra Zielinska, Jacek Karczewski, Piotr Eder, Tomasz Kolanowski, Milena Szalata, Karolina Wielgus, Marlena Szalata, Dohun Kim, Su Ryon Shin, Ryszard Slomski, Eliana B. Souto
Summary: Scaffolds are commonly used implants for delivering cells, drugs, and genes, with their porous structure providing support for cell attachment, proliferation, differentiation, and migration. Various techniques are used to fabricate scaffolds, and they have applications in tissue engineering and multiple medical fields.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Venancio A. Amaral, Juliana Ferreira de Souza, Thais F. R. Alves, Fernando Batain, Denicezar A. Baldo, Patricia Severino, Norberto Aranha, Eliana B. Souto, Marco V. Chaud
Summary: The aim of this study was to develop a dense lamellar scaffolding composed of collagen, silk fibroin, and polyethylene glycol 400, and to evaluate the influence of freezing parameters on its structure. The results showed that freezing rate could modulate the pore size, connectivity, and anisotropy of the scaffolds. This study provides important insights for potential tissue engineering applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Tatiana N. Pashirova, Andrey V. Nemtarev, Eliana B. Souto, Vladimir F. Mironov
Summary: This review provides a systematic survey of studies on mitochondria-targeted nanosystems containing triphenylphosphonium vector groups, summarizing the design principles and preparation methods for these nanosystems and analyzing the relationship between key parameters and biological action.
RUSSIAN CHEMICAL REVIEWS
(2023)
Article
Green & Sustainable Science & Technology
Faezeh Fathi, Reza M. Kouchaksaraee, Samad N. Ebrahimi, Anabela S. G. Costa, Eliana B. Souto, Joao A. Prior, M. Beatriz P. P. Oliveira, Rita C. Alves
Summary: This study aimed to develop an antioxidant-rich grape seed (GS) fraction and formulate appropriate delivery systems for oral administration. Phenolic compounds were enriched in a hydroethanolic extract of GS using adsorbent resin column chromatography, resulting in a 4-fold increase in phenolic content compared to the crude extract. The enriched fraction was loaded into cholesterol-incorporated phytosomes to improve stability, gut absorption, and oral bioavailability. Different polysaccharide-based polymers were tested as natural-based coatings to improve stability and protection against gastrointestinal degradation, while providing a modified-release profile. The phytosomes showed potential as smart nutraceuticals for dietary supplements.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)