Article
Oncology
Summer Y. Y. Ha, Yasuaki Anami, Chisato M. Yamazaki, Wei Xiong, Candice M. Haase, Scott D. Olson, Jangsoon Lee, Naoto T. Ueno, Ningyan Zhang, Zhiqiang An, Kyoji Tsuchikama
Summary: The glutamic acid-glycine-citrulline (EGCit) linker has been found to address the stability issues of Valine-citrulline linker in drug delivery, without compromising drug release and ADC therapeutic efficacy. EGCit conjugates resist degradation by neutrophil proteases and show potent antitumor activity with minimal blood and liver toxicity.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Chemistry, Medicinal
Jianjun Qi, Zihua Zeng, Zhenghu Chen, Cole Nipper, Xiaohui Liu, Quanyuan Wan, Jian Chen, Ching-Hsuan Tung, Youli Zu
Summary: Gemcitabine is a chemotherapeutic drug that may have adverse effects on patients due to lack of tumor cell specificity. To improve its therapeutic efficacy, researchers synthesized a novel aptamer-drug conjugate that carries a high drug payload and allows controlled drug release. This approach achieved higher therapeutic efficacy and reduced off-target effects compared to free-drug chemotherapy.
Article
Chemistry, Multidisciplinary
Fei Wu, Pei-Ming Chen, Thomas C. Gardinier, Melik Z. Turker, Aranapakam M. Venkatesan, Vaibhav Patel, Tin Khor, Michelle S. Bradbury, Ulrich B. Wiesner, Gregory P. Adams, Geno Germano, Feng Chen, Kai Ma
Summary: An ultrasmall folate receptor alpha (FR alpha) targeted silica nanoparticle (C'Dot) drug conjugate (CDC) was developed to address the limitations of current systemic drug delivery for cancer management. The lead candidate formulation demonstrated specific targeting, multivalent binding properties, enzymatic responsive payload cleavage, stability in human plasma, rapid clearance, and minimal organ retention. It also showed superior efficacy in tumor penetration, cytotoxicity, and therapeutic outcome in various tumor models expressing different levels of FR alpha.
Article
Chemistry, Medicinal
Meghan K. O'Leary, Asraa Ahmed, Christopher A. Alabi
Summary: Novel antimicrobial agents are needed to treat infections caused by multidrug-resistant extracellular pathogens. Antibody-drug conjugates have shown success in delivering highly cytotoxic drugs directly to target cells, and this strategy can be applied to the treatment of infections by utilizing an antibody to deliver an antimicrobial agent.
ACS INFECTIOUS DISEASES
(2023)
Article
Chemistry, Medicinal
Meghan K. O'Leary, Christopher A. Alabi, Asraa Ahmed
Summary: The development of an antibody-bactericide conjugate (ABC) that targets the antimicrobial peptide oligoTEA to treat infections caused by multidrug-resistant extracellular pathogens such as Pseudomonas aeruginosa is proposed. The ABC binds to the bacterial cell surface and releases the oligoTEA payload, exhibiting antipseudomonal activity.
ACS INFECTIOUS DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Nicola Ashman, Jonathan D. Bargh, Stephen J. Walsh, Ryan D. Greenwood, Arnaud Tiberghien, Jason S. Carroll, David R. Spring
Summary: Antibody-drug conjugates with peroxide-cleavable arylboronic acid linkers are developed to target cancer cells with high levels of reactive oxygen species (ROS). These linkers can rapidly release drugs in the presence of hydrogen peroxide while remaining stable in plasma. The peroxide-cleavable ADCs targeting HER2 and PD-L1 exhibit potent cytotoxicity in vitro.
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Seetharamsing Balamkundu, Chuan-Fa Liu
Summary: Antibody-drug conjugates (ADCs) are a powerful therapeutic modality for cancer treatment, and the success of ADCs depends on the development of linker systems that allow for targeted release of drugs. Currently, there is a focus on improving the stability of ADC linkers in human plasma while maintaining lysosomal cleavability. This review provides an overview of recent advances in the design and structure-activity relationship studies of various peptide/peptidomimetic linkers in this field.
Article
Chemistry, Medicinal
Michal Nowak, Andrzej S. Skwarecki, Joanna Pilch, Justyna Gorska, Piotr Szweda, Maria J. Milewska, Slawomir Milewski
Summary: Conjugates composed of C2-18 fatty acid residues as carriers and 5-fluorocytosine as an active agent showed good in vitro activity against Candida spp. The most active conjugates containing C8, C10, C12, or C14 acid residues had MIC values in the range of 2-64 mu g mL-1, except for Candida krusei. The less active conjugates containing C2, C16, or C18 fatty acids were slowly hydrolyzed by esterase and poorly taken up by Candida cells, similar to their analogs with a fluorescent label instead of 5-FC.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jacopo F. A. A. Amari, Sara Sangiorgio, Eleonora Pargoletti, Marco Rabuffetti, Federica Zaccheria, Fabio Usuelli, Valeria Quaranta, Giovanna Speranza, Giuseppe Cappelletti
Summary: Polyglycerol fatty acid esters (PGFAEs) were synthesized using enzymatic esterification and their emulsifying properties were compared with chemically synthesized and commercially available esters.
Article
Chemistry, Multidisciplinary
Jonathan D. Bargh, Stephen J. Walsh, Nicola Ashman, Albert Isidro-Llobet, Jason S. Carroll, David R. Spring
Summary: A novel enzyme cleavable linker for antibody-drug conjugates, utilizing a highly hydrophilic dual-cleavable 3-O-sulfo-beta-galactose linker, shows excellent cytotoxicity and selectivity in targeted cells when used to synthesize an alpha-HER2 antibody-drug conjugate.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Matthew Drayton, Morgan A. Alford, Daniel Pletzer, Evan F. Haney, Yoan Machado, Haiming D. Luo, Christopher M. Overall, Jayachandran N. Kizhakkedathu, Robert E. W. Hancock, Suzana K. Straus
Summary: A novel PEG-HDP conjugate was designed targeting MMPs at sites of inflammation and infection, enhancing antimicrobial activity through enzymatic cleavage while improving biocompatibility, demonstrated by strong antibacterial efficacy in a mouse abscess model with high-density MRSA infection.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Materials Science, Multidisciplinary
Roberto Bernasconi, Emanuele Mauri, Arianna Rossetti, Stefano Rimondo, Raffaella Suriano, Marinella Levi, Alessandro Sacchetti, Salvador Pane, Luca Magagnin, Filippo Rossi
Summary: Targeted drug delivery is a promising approach that utilizes stimuli-responsive materials to control drug release with spatial and temporal precision. This study describes coating magnetically controlled microdevices with functionalized alginate-based hydrogels for drug release at specific pH values, showcasing the potential for spatially and temporally controlled release. The functional microtransporters hold promise for in-vivo applications, particularly in environments with pH differences like the digestive tract.
MATERIALS & DESIGN
(2021)
Article
Medicine, Research & Experimental
Tong-Fei Li, Hua-Zhen Xu, Yong-Hong Xu, Ting-Ting Yu, Jun-Ming Tang, Ke Li, Chao Wang, Xing-Chun Peng, Qi-Rui Li, Xue-Yu Sang, Mei-Yan Zheng, Yan Liu, Li Zhao, Xiao Chen
Summary: This study successfully addressed the limitations of Chlorin e6 (Ce6) in tumor photodynamic therapy by using functionalized superparamagnetic iron oxide nanoparticles as carriers. The nanoparticles significantly increased Ce6 uptake in melanoma cells, leading to enhanced therapeutic effects.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Sajini D. Hettiarachchi, Emel Kirbas Cilingir, Heidi Maklouf, Elif S. Seven, Suraj Paudyal, Steven Vanni, Regina M. Graham, Roger M. Leblanc
Summary: This study compared three different covalent carbon dots systems for doxorubicin release and cancer cell viability under acidic and physiological conditions. Results indicated that the pH stimuli C-dots-HBA-dox system showed the highest efficacy in doxorubicin release in acidic pH, while the redox stimuli C-dots-S-S-dox system performed well in physiological conditions.
Article
Multidisciplinary Sciences
Paria Pouyan, Anne Zemella, Jeffrey L. Schlosshauer, Ruben M. Walter, Rainer Haag, Stefan Kubick
Summary: With over 20 FDA-approved PEG modified drugs on the market, PEG is the preferred polymer for bioconjugation due to its improved stability and blood circulation time. However, reports have shown allergic reactions to PEG, which can lead to reduced drug efficiency and anaphylactic reactions. This study introduces linear polyglycerol (LPG) as an alternative to PEG for bioconjugation, demonstrating similar characteristics and promising potential.
SCIENTIFIC REPORTS
(2023)
Article
Materials Science, Multidisciplinary
Sana Azim, Lindsey A. Bultema, Michiel B. de Kock, Ernesto Rafael Osorio-Blanco, Marcelo Calderon, Josef Gonschior, Jan-Philipp Leimkohl, Friedjof Tellkamp, Robert Buecker, Eike C. Schulz, Sercan Keskin, Niels de Jonge, Gunther H. Kassier, R. J. Dwayne Miller
Summary: Liquid-phase transmission electron microscopy is a technique that allows for simultaneous imaging of sample structure and dynamics in a liquid environment. By adjusting the thickness of the liquid layer and controlling the electron dose, high-resolution observations of low mass-thickness contrast objects can be achieved. The use of an environmental liquid cell (ELC) enables researchers to study hydration effects and investigate liquid samples in situ.
MICROSCOPY AND MICROANALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Ankita Singh, Shashwat Malhotra, Devla Bimal, Lydia M. Bouchet, Stefanie Wedepohl, Marcelo Calderon, Ashok K. Prasad
Summary: Novel pyrimidine-based cationic amphiphiles were synthesized using naturally occurring biocompatible precursors, demonstrating excellent anti-tubercular activity, with one compound showing significantly higher activity against multidrug-resistant clinical isolates of Mycobacterium tuberculosis compared to first-line anti-tubercular drugs streptomycin and isoniazid.
Article
Polymer Science
Julio C. Cuggino, Matias L. Picchio, Agustina Gugliotta, Milagros Burgi, Ludmila Ronco, Marcelo Calderon, Marina Etcheverrigaray, Cecilia I. Alvarez Igarzabal, Roque J. Minari, Luis M. Gugliotta
Summary: Nanomedicine for cancer therapy has shown success in reducing the side effects of chemotherapeutics like paclitaxel through the use of alternative nanocarriers. Casein micelles, a low-cost protein, can efficiently encapsulate PTX and be used as promising nanoformulations for cancer therapy. The chemically crosslinked casein micelles present a potential candidate for parenteral administration with passive targeting and controlled drug release in tumor microenvironment.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Materials Science, Biomaterials
Anna Puiggali-Jou, Stefanie Wedepohl, Loryn E. Theune, Carlos Aleman, Marcelo Calderon
Summary: A semi-interpenetrated nanogel designed to release and sense diclofenac as a photothermal agent for cancer cell ablation shows promise when combined with chemotherapy. The study demonstrates the potential of semi-interpenetrated nanogels for drug delivery, sensing capabilities, and mild photothermal therapy, with the ability to kill 95% of cells in vitro.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Edurne Marin, Neha Tiwari, Marcelo Calderon, Jose-Ramon Sarasua, Aitor Larranaga
Summary: Polymer capsules fabricated via the layer-by-layer approach show promise for controlled enzymatic reactions and drug release in response to biologically relevant stimuli, with the potential to target multiple mediators of inflammatory diseases.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Neha Tiwari, Ernesto Rafael Osorio-Blanco, Ana Sonzogni, David Esporrin-Ubieto, Huiyi Wang, Marcelo Calderon
Summary: Nanosized carrier systems offer a promising alternative for improving skin penetration of therapeutic molecules with minimal damage to the skin's natural barrier. The use of nanoparticles for delivering drugs, genetic material, and vaccines into the skin is discussed, along with the importance of nanotoxicology studies and recent clinical developments in shedding light on their potential for market translation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Maria Soledad Orellano, Oihane Sanz, Sandra Camarero-Espinosa, Ana Beloqui, Marcelo Calderon
Review
Nanoscience & Nanotechnology
Huiyi Wang, Matias L. Picchio, Marcelo Calderon
Summary: Inspired by the development of nanomedicine and nanotechnology, the field of cancer theranostics has seen significant progress in recent years. Nanogels, with their unique attributes such as high stability and encapsulation capacity, have been extensively studied for drug delivery and various bioimaging techniques.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Polymer Science
Emanuel A. Glitscher, Julian Bergueiro, Marcelo Calderon
Summary: The novel strategy of incorporating anisotropic gold nanoparticles into polymeric thermoresponsive nanogels has expanded their potential applications in the field of nanomedicine.
EUROPEAN POLYMER JOURNAL
(2022)
Meeting Abstract
Ophthalmology
Arantxa Acera, David Esporrin, Aitor Diaz, Juliana De Souza, Mercedes Fernandez, Jorge Burgos, Javier Zabalza, Xandra Pereiro, Marcelo Calderon, Damien Dupin, Elena Vecino
ACTA OPHTHALMOLOGICA
(2022)
Article
Engineering, Biomedical
Maria Beatrice Bianchi, Chunyang Zhang, Elise Catlin, Giuseppina Sandri, Marcelo Calderon, Eneko Larraneta, Ryan F. Donnelly, Matias L. Picchio, Alejandro J. Paredes
Summary: Egels are emerging soft ionic materials with excellent elasticity, non-volatile nature, and adhesion properties, making them suitable for drug delivery. This study reports the first example of adhesive Egels loading drug nanocrystals for controlled delivery to mucosal tissues.
MATERIALS TODAY BIO
(2022)
Article
Polymer Science
Miren Aguirre, Nicholas Ballard, Edurne Gonzalez, Shaghayegh Hamzehlou, Haritz Sardon, Marcelo Calderon, Maria Paulis, Radmila Tomovska, Damien Dupin, Ren H. Bean, Timothy E. Long, Jose R. Leiza, Jose M. Asua
Summary: The water-based emulsion polymerization process has led to the continuous growth in commercial use of polymer colloids due to its high efficiency and versatility in production. This perspective highlights the challenges in synthesis and application of polymer colloids, including the transition towards sustainable feedstocks and reduced environmental impact in their primary applications, as well as the design and application of novel polymer colloids in emerging areas. Unconventional processing techniques utilizing the unique colloidal nature are also presented.
Article
Polymer Science
Alexis Wolfel, Huiyi Wang, Ernesto Rafael Osorio-Blanco, Julian Bergueiro, Marcelo Ricardo Romero, Cecilia Ines Alvarez Igarzabal, Marcelo Calderon
Summary: Advancements in nanogel applications require precise control over their size, structure, and functionalization. In this work, a post-synthesis reaction strategy was developed to modify the structure and functionalization of thermoresponsive nanogels. The incorporation of a cleavable crosslinker allows control over the crosslinking degree and architecture of the nanogels, and introduces alpha-oxoaldehydes for subsequent bio-conjugation. This strategy provides a valuable tool for fine-tuning drug delivery nanodevices in a post-synthetic step.
Article
Materials Science, Biomaterials
Julian Bergueiro, Emanuel A. Glitscher, Marcelo Calderon
Summary: Temperature-trigger chemotherapy is an advanced anti-tumoral strategy in nanomedicine. A nanogel system composed of a thermoresponsive polymer cross-linked by plasmonic gold nanoparticles (AuNPs) has been constructed for temperature-trigger chemotherapy. Experimental results showed that the temperatures reached in the in vivo near infrared irradiation had a negative effect on the inhibition of the tumor growth, while the drug loaded systems considerably reduced the tumor sizes.
BIOMATERIALS ADVANCES
(2022)
Review
Materials Science, Biomaterials
Balram Singh, Smriti Arora, Alain D'Souza, Narendra Kale, Gourishankar Aland, Atul Bharde, Mohiuddin Quadir, Marcelo Calderon, Pankaj Chaturvedi, Jayant Khandare
Summary: This article discusses the revolutionary progress in next-generation clinically relevant technologies achieved through advanced materials and chemo-specific designs at the nano/micrometer-scale, focusing on the complexities of isolating and enumerating CTCs in cancer diagnostics. The importance of utilizing chemically specific substrates and methods for enhancing cell interaction specificity and efficiency with targeted tumor cells is highlighted, along with the significance of CTC capture and downstream processes for real-time detection of metastases progression and chemotherapy treatment response in cancer patients.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
