Interrogating HIV integrase for compounds that bind- a SAMPL challenge

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase–LEDGF/p75 interaction

(2013) Erik Serrao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Clinical Use of HIV Integrase Inhibitors: A Systematic Review and Meta-Analysis

(2013) Peter Messiaen et al.   PLoS One

Non-Catalytic Site HIV-1 Integrase Inhibitors Disrupt Core Maturation and Induce a Reverse Transcription Block in Target Cells

(2013) Mini Balakrishnan et al.   PLoS One

The antiretroviral drug pipeline

(2013) Charles Flexner et al.   Current Opinion in HIV and AIDS

Emerging patterns and implications of HIV-1 integrase inhibitor resistance

(2012) Anna Maria Geretti et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

(2012) Thomas S. Peat et al.   PLoS One

Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression

(2011) Paradise Madlala et al.   AIDS

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

(2011) Laura De Luca et al.   ANTIVIRAL RESEARCH

Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: A scaffold hopping approach using salicylate and catechol groups

(2011) Xing Fan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Crystal Structures of Novel Allosteric Peptide Inhibitors of HIV Integrase Identify New Interactions at the LEDGF Binding Site

(2011) David I. Rhodes et al.   CHEMBIOCHEM

Inhibitors of the Interactions between HIV-1 IN and the Cofactor LEDGF/p75

(2011) Laura De Luca et al.   ChemMedChem

Role of the PWWP Domain of Lens Epithelium-derived Growth Factor (LEDGF)/p75 Cofactor in Lentiviral Integration Targeting

(2011) Rik Gijsbers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vitro DNA Tethering of HIV-1 Integrase by the Transcriptional Coactivator LEDGF/p75

(2011) Melissa McNeely et al.   JOURNAL OF MOLECULAR BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

(2010) Frauke Christ et al.   Nature Chemical Biology

Pharmacophore-Based Discovery of Small-Molecule Inhibitors of Protein-Protein Interactions between HIV-1 Integrase and Cellular Cofactor LEDGF/p75

(2009) Laura De Luca et al.   ChemMedChem

Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex

(2009) Manuel Tsiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75

(2009) Stephen Hare et al.   PLoS Pathogens

Surface Plasmon Resonance Based Assay for the Detection and Characterization of Promiscuous Inhibitors

(2008) Anthony M. Giannetti et al.   JOURNAL OF MEDICINAL CHEMISTRY