Inflation of correlation in the pursuit of drug-likeness

Medicinal chemistry matters – a call for discipline in our discipline

(2012) Craig Johnstone   DRUG DISCOVERY TODAY

Impact of Lipophilic Efficiency on Compound Quality

(2012) Ákos Tarcsay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Computation, experiment and molecular design

(2011) Peter W. Kenny   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

If we designed airplanes like we design drugs…

(2011) Walter S. Woltosz   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Getting physical in drug discovery: a contemporary perspective on solubility and hydrophobicity

(2010) Alan P. Hill et al.   DRUG DISCOVERY TODAY

The graphical representation of ADME-related molecule properties for medicinal chemists

(2010) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Computational Medicinal Chemistry

(2010) Martin Stahl et al.   JOURNAL OF MEDICINAL CHEMISTRY

The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

(2010) Dennis A. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Hydrogen Bonding, Electrostatic Potential, and Molecular Design

(2009) Peter W. Kenny   Journal of Chemical Information and Modeling

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

High throughput solubility determination with application to selection of compounds for fragment screening

(2008) Nicola Colclough et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY