Elaborate ligand-based modeling coupled with QSAR analysis and in silico screening reveal new potent acetylcholinesterase inhibitors

Extensive ligand-based modeling and in silico screening reveal nanomolar inducible nitric oxide synthase (iNOS) inhibitors

(2012) Ghadeer A.R.Y. Suaifan et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Ligand-based modelling followed by synthetic exploration unveil novel glycogen phosphorylase inhibitory leads

(2011) Maha Habash et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Elaborate ligand-based modeling and subsequent synthetic exploration unveil new nanomolar Ca2+/calmodulin-dependent protein kinase II inhibitory leads

(2011) Rand Shahin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of New Antifungal Leads via Pharmacophore Modeling and QSAR Analysis of Fungal N-Myristoyl Transferase Inhibitors Followed by In Silico Screening

(2011) Mutasem O. Taha et al.   Chemical Biology & Drug Design

Discovery of new nanomolar peroxisome proliferator-activated receptor γ activators via elaborate ligand-based modeling

(2011) Belal O. Al-Najjar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Elaborate ligand-based modeling reveal new submicromolar Rho kinase inhibitors

(2011) Rand Shahin et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Discovery of new renin inhibitory leads via sequential pharmacophore modeling, QSAR analysis, in silico screening and in vitro evaluation

(2011) Afaf H. Al-Nadaf et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Lead Finding for Acetyl Cholinesterase Inhibitors from Natural Origin: Structure Activity Relationship and Scope

(2011) P. K. Mukherjee et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Elaborate ligand-based pharmacophore exploration and QSAR analysis guide the synthesis of novel pyridinium-based potent β-secretase inhibitory leads

(2010) Afaf Al-Nadaf et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration

(2010) Reema Abu Khalaf et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel CDK1 inhibitors by combining pharmacophore modeling, QSAR analysis and in silico screening followed by in vitro bioassay

(2010) Mahmoud A. Al-Sha’er et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Elaborate Ligand-Based Modeling Reveals New Nanomolar Heat Shock Protein 90α Inhibitors

(2010) Mahmoud A. Al-Sha’er et al.   Journal of Chemical Information and Modeling

Hybrid Molecules from Xanomeline and Tacrine: Enhanced Tacrine Actions on Cholinesterases and Muscarinic M1Receptors

(2010) Lei Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bivalent β-Carbolines as Potential Multitarget Anti-Alzheimer Agents

(2010) Yvonne Rook et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacophore Modeling, Quantitative Structure−Activity Relationship Analysis, and Shape-Complementedin SilicoScreening Allow Access to Novel Influenza Neuraminidase Inhibitors

(2009) Areej M. Abu Hammad et al.   Journal of Chemical Information and Modeling

Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties

(2008) Michael Decker et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of tacrine–ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates

(2008) Lei Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of DPP IV Inhibitors by Pharmacophore Modeling and QSAR Analysis followed by in silico Screening

(2008) Ihab M. Al-masri et al.   ChemMedChem

Amyloid-cholinesterase interactions

(2008) Nibaldo C. Inestrosa et al.   FEBS Journal

Pharmacophore Modeling, Quantitative Structure–Activity Relationship Analysis, and in Silico Screening Reveal Potent Glycogen Synthase Kinase-3β Inhibitory Activities for Cimetidine, Hydroxychloroquine, and Gemifloxacin

(2008) Mutasem O. Taha et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combining Ligand-Based Pharmacophore Modeling, Quantitative Structure−Activity Relationship Analysis and in Silico Screening for the Discovery of New Potent Hormone Sensitive Lipase Inhibitors

(2008) Mutasem O. Taha et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of NO-Donor-Tacrine Hybrids as Hepatoprotective Anti-Alzheimer Drug Candidates

(2008) Lei Fang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of new MurF inhibitors via pharmacophore modeling and QSAR analysis followed by in-silico screening

(2007) Mutasem O. Taha et al.   BIOORGANIC & MEDICINAL CHEMISTRY