Active site similarity between human and Plasmodium falciparum phosphodiesterases: considerations for antimalarial drug design

Drug to Genome to Drug: Discovery of New Antiplasmodial Compounds

(2011) Terence B. Beghyn et al.   JOURNAL OF MEDICINAL CHEMISTRY

That Was Then But This Is Now: Malaria Research in the Time of an Eradication Agenda

(2010) S. H. I. Kappe et al.   SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

(2009) Michael P. DeNinno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

(2009) Helen M. Taylor et al.   EUKARYOTIC CELL

Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†† Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

(2009) Patrick R. Verhoest et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Cyclic GMP Signalling Module That Regulates Gliding Motility in a Malaria Parasite

(2009) Robert W. Moon et al.   PLoS Pathogens

Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEα, a non-essential cGMP-specific PDE that is an integral membrane protein

(2008) Laurent Wentzinger et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Disruption of aPlasmodium falciparumcyclic nucleotide phosphodiesterase gene causes aberrant gametogenesis

(2008) Cathy J. Taylor et al.   MOLECULAR MICROBIOLOGY

Structural basis for the catalytic mechanism of human phosphodiesterase 9

(2008) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gametogenesis in Malaria Parasites Is Mediated by the cGMP-Dependent Protein Kinase

(2008) Louisa McRobert et al.   PLOS BIOLOGY