Article
Toxicology
Maria Battistoni, Francesca Metruccio, Francesca Di Renzo, Renato Bacchetta, Elena Menegola
Summary: The present study compared different methodologies to identify craniofacial malformations in Xenopus laevis assay. The results suggest that the deglutition test is a reliable method for rapidly screening craniofacial abnormalities.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Health Care Sciences & Services
Valentin Kerkfeld, Lara Schorn, Rita Depprich, Julian Lommen, Max Wilkat, Norbert Kubler, Majeed Rana, Ulrich Meyer
Summary: This study compared the outcome of facial symmetry in patients with craniofacial malformations who underwent simultaneous digitally planned patient-specific implant (PSI-) based orthognathic surgery and polyether ether ketone (PEEK) bone augmentation. The results showed that simultaneous PEEK bone augmentation significantly improves facial symmetry compared to conventional orthognathic surgery, even in patients with syndrome-related underdevelopment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Hannah J. Petty, Jacob E. Barrett, Erin G. Kosmowski, Dandre S. Amos, Sean M. Ryan, Lucas D. Jones, Christopher S. Lassiter
Summary: In this study, the effects of spironolactone on cardiovascular and craniofacial development in zebrafish embryos were investigated. The results suggest that further research on the impact of spironolactone on embryonic development is necessary.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Madleen Busse, Jaroslaw P. Marciniszyn, Simone Ferstl, Melanie A. Kimm, Franz Pfeiffer, Tanja Gulder
Summary: Conventional histology is based on evaluating 2D slices of a 3D biopsy, while 3D X-ray histology overcomes this limitation by enhancing soft tissue X-ray contrast through tissue staining before CT imaging. The ideal X-ray contrast agent, dibromo fluorescein barium salt, allows for 3D imaging and subsequent complementing counterstaining using standard histological techniques.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Environmental Sciences
Zekun Li, Kun Jia, Xiaomei Chen, Jun Guo, Zhiguo Zheng, Weihua Chen, Yuan Peng, Yuhao Yang, Huiqiang Lu, Jian Yang
Summary: This study investigated the developmental toxicity of Butylparaben (BuP) in zebrafish embryos, and found that exposure to BuP caused severe craniofacial deformities, periocular edema, cardiac dysplasia, and delayed otolith development in zebrafish larvae. The oxidative stress response was enhanced, and the activities of catalase and superoxide dismutase were reduced while the concentration of malondialdehyde was elevated. In addition, ALP activity and the expression of chondrocyte marker genes were decreased. These findings indicate that BuP-induced oxidative stress inhibits the proliferation of neural crest cells (NCCs), leading to craniofacial deformities.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Manufacturing
Jacques Kruger, Anton du Plessis, Gideon van Zijl
Summary: Concrete structures produced by extrusion-based 3D printing exhibit orthotropic mechanical behavior and relative weakness in interfacial regions. The microstructure, including porosity content and distribution, plays a key role in these properties and can be visualized and quantified using X-ray computed tomography. Further research is needed to understand the effect of stress concentrations at micro-cracks or voids in 3D printed concrete on mechanical behavior.
ADDITIVE MANUFACTURING
(2021)
Article
Computer Science, Artificial Intelligence
Stylianos Ploumpis, Evangelos Ververas, Eimear O'Sullivan, Stylianos Moschoglou, Haoyang Wang, Nick Pears, William A. P. Smith, Baris Gecer, Stefanos Zafeiriou
Summary: The study introduces the most complete 3DMM of the human head to date, which combines existing models of different overlapping head parts to achieve state-of-the-art performance. The new model builds a combined face-and-head shape model that blends the variability and facial detail of an existing face model with the full head modelling capability of an existing head model.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2021)
Article
Developmental Biology
Ryan P. Liegel, Megan N. Michalski, Sanika Vaidya, Elizabeth Bittermann, Erin Finnerty, Chelsea A. Menke, Cassandra R. Diegel, Zhendong A. Zhong, Bart O. Williams, Rolf W. Stottmann
Summary: Researchers created a mouse model using gene editing technology to study the pathogenicity of FZD2 variants and found potential therapeutic interventions for Robinow syndrome.
Article
Computer Science, Artificial Intelligence
Yuan Li, Jian Wang, Weibo Liang, Hui Xue, Zhenan He, Jiancheng Lv, Lin Zhang
Summary: This study proposes a novel craniofacial reconstruction method to identify human remains by synthesizing corresponding craniofacial images from 2D skull images. The method utilizes deep generative adversarial nets to automatically transform skull data to facial images. Experimental results demonstrate that the method can be used as an effective forensic tool.
PATTERN RECOGNITION
(2022)
Article
Pharmacology & Pharmacy
Andrzej Hudecki, Weronika Wolany, Wirginia Likus, Jaroslaw Markowski, Renata Wilk, Aleksandra Kolano-Burian, Katarzyna Luczak, Magdalena Zorychta, Marek Kawecki, Marek J. Los
Summary: The reconstruction of large cavities in the skull and facial regions is crucial for restoring health and correcting facial distortions, as visible deformities can impact mental wellness and social perception. With the degradation of the natural environment, cancer is expected to become a leading cause of morbidity and mortality in the coming years. This review focuses on the causes of injuries leading to orbital cavity removal and reconstruction, as well as the materials used for reconstruction and the challenges faced in facial and craniofacial reconstruction in cancer patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Anatomy & Morphology
Sejin Choi, Kyung Hyun Kim, Seung-Ki Kim, Kyu-Chang Wang, Ji Yeoun Lee
Summary: This study successfully visualized the gross morphology of chick embryos at different developmental stages and presented the detailed structure of the caudal cell mass from HH12 to 16. It also showed the spatiotemporal relationship between the caudal cell mass, floor plate of the neural tube, and notochord, as well as described the dynamic changes during early stages of secondary neurulation.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Surgery
Debra A. Bourne, Jacqueline Bliley, Isaac James, Albert D. Donnenberg, Vera S. Donnenberg, Barton F. Branstetter, Gretchen L. Haas, Elizabeth Radomsky, Ernest Michael Meyer, Melanie E. Pfeifer, Spencer A. Brown, Kacey G. Marra, Sydney Coleman, J. Peter Rubin
Summary: This study assessed the outcomes of surgical autologous fat transfer (AFT) for traumatic and postsurgical craniofacial deformities, demonstrating that AFT is less invasive and safer than traditional reconstructive options, while also positively impacting quality of life.
Review
Biochemistry & Molecular Biology
Shoko Onodera, Toshifumi Azuma
Summary: This article introduces the important roles of various signaling mediators in the Hh family in different stages of development, and the significance of the Hh pathway in bone tissue development and tumorigenesis. Gorlin syndrome is a skeletal and tumorigenic disorder caused by gain-of-function mutations in Hh signaling. The article first presents the phenotype of Gorlin syndrome and the relationship between genotype and phenotype in bone and craniofacial tissues, including the causative gene as well as other Hh-related genes. Next, the importance of new diagnostic methods using next-generation sequencing and multiple gene panels is discussed. Finally, the article summarizes Hh-related genetic disorders, including cilia disease, and the genetics of Hh-related bone diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Alba Scerrati, Francesco Travaglini, Clarissa Ann Elisabeth Gelmi, Andrea Lombardo, Pasquale De Bonis, Michele Alessandro Cavallo, Paolo Zamboni
Summary: The study introduced a new method using 3D printing to produce patient specific PMMA cranioplasty, with a total of seven procedures performed. The average surgery time was 80 minutes, and all cranioplasties matched the patient specific anatomy perfectly without any complications.
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
(2022)
Article
Multidisciplinary Sciences
Jonathan Schwartz, Chris Harris, Jacob Pietryga, Huihuo Zheng, Prashant Kumar, Anastasiia Visheratina, Nicholas A. Kotov, Brianna Major, Patrick Avery, Peter Ercius, Utkarsh Ayachit, Berk Geveci, David A. Muller, Alessandro Genova, Yi Jiang, Marcus Hanwell, Robert Hovden
Summary: The authors demonstrate real-time tomography with dynamic 3D tomographic visualization integrated in tomviz, enabling rapid interpretation of specimen structure and obtaining high-quality tomograms in a short period of time.
NATURE COMMUNICATIONS
(2022)
