期刊
NMR IN BIOMEDICINE
卷 28, 期 3, 页码 384-394出版社
WILEY
DOI: 10.1002/nbm.3262
关键词
MR fingerprinting; high-field MRI; preclinical; mouse; kidney; brain; respiratory motion artifacts
资金
- NIH/NIDDK [RO1 DK085099, K12 DK100014]
- NIH/NCI [R01 CA179956]
- NIH/NIBIB [R01 EB017219]
- Case Comprehensive Cancer Center [NIH/NCI P30 CA43703]
- Clinical and Translation Science Collaborative of Cleveland [NIH/NCATS UL1 TR000439]
High-field preclinical MRI scanners are now commonly used to quantitatively assess disease status and the efficacy of novel therapies in a wide variety of rodent models. Unfortunately, conventional MRI methods are highly susceptible to respiratory and cardiac motion artifacts resulting in potentially inaccurate and misleading data. We have developed an initial preclinical 7.0-T MRI implementation of the highly novel MR fingerprinting (MRF) methodology which has been described previously for clinical imaging applications. The MRF technology combines a priori variation in the MRI acquisition parameters with dictionary-based matching of acquired signal evolution profiles to simultaneously generate quantitative maps of T-1 and T-2 relaxation times and proton density. This preclinical MRF acquisition was constructed from a fast imaging with steady-state free precession (FISP) MRI pulse sequence to acquire 600 MRF images with both evolving T-1 and T-2 weighting in approximately 30 min. This initial high-field preclinical MRF investigation demonstrated reproducible and differentiated estimates of in vitro phantoms with different relaxation times. In vivo preclinical MRF results in mouse kidneys and brain tumor models demonstrated an inherent resistance to respiratory motion artifacts as well as sensitivity to known pathology. These results suggest that MRF methodology may offer the opportunity for the quantification of numerous MRI parameters for a wide variety of preclinical imaging applications. Copyright (c) 2015 John Wiley & Sons, Ltd.
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