Article
Cardiac & Cardiovascular Systems
Jwan A. Naser, Eunjung Lee, Christopher G. Scott, Austin M. Kennedy, Patricia A. Pellikka, Grace Lin, Sorin Pislaru, Barry A. Borlaug
Summary: This study aimed to investigate the prevalence and incidence of DD in patients with new-onset AF compared with SR. The results showed that patients with new-onset AF have high-risk features for HFpEF at diagnosis and accelerated progression in DD over time.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Alena Yakimenka, Dina Labib, Steven Dykstra, Yoko Mikami, Alessandro Satriano, Jacqueline Flewitt, Patricia Feuchter, Sandra Rivest, Andrew G. Howarth, Carmen P. Lydell, F. Russell Quinn, Stephen B. Wilton, James A. White
Summary: This prospective cohort study aimed to evaluate the sex-based differences in cardiac phenotype and their influence on AF recurrence following first-time PVI. The study found that females had significantly poorer left atrial (LA) contractile health and higher risk of AF recurrence. Assessment of LA contractile health may be valuable in identifying female patients at elevated risk of AF recurrence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Henry Sutanto, Dobromir Dobrev, Jordi Heijman
Summary: The RAAS system plays a crucial role in cardiovascular health and disease, with short-term activation being beneficial but long-term activation detrimental. Natriuretic peptides are activated to counterbalance the effects of RAAS, facilitating water and salt excretion and causing vasodilation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Matteo Gadaleta, Patrick Harrington, Eric Barnhill, Evangelos Hytopoulos, Mintu P. Turakhia, Steven R. Steinhubl, Giorgio Quer
Summary: Early identification of atrial fibrillation (AF) is crucial in reducing the risk of serious cardiovascular outcomes. This study developed a model using a deep learning approach to predict the near-term risk of AF based on electrocardiogram (ECG) data. The model showed high accuracy in predicting AF over a two-week period, providing a potential digital strategy for improving diagnosis and treatment initiation.
NPJ DIGITAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aseel Alfuhied, Benjamin A. Marrow, Sara Elfawal, Gaurav S. Gulsin, Mathew P. Graham-Brown, Christopher D. Steadman, Prathap Kanagala, Gerry P. McCann, Anvesha Singh
Summary: The test-retest reproducibility of LA strain and strain rate assessment using CMR is moderate to poor, while LA volume and emptying fraction assessment is more reproducible. Intra- and inter-observer variabilities were good for most parameters except for conduit function. Further improvements in LA strain quantification are necessary before widespread clinical application.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, Research & Experimental
Michael L. Fitch, Raihan Kabir, Obialunanma V. Ebeneb, Nicole Taube, Haley Garbus, Prithvi Sinha, Nadan Wang, Sumita Mishra, Brian L. Lin, Grace K. Muller, Mark J. Kohr
Summary: The aim of this study was to investigate the effects of chronic cadmium exposure on the structure and function of the heart. Male mice exhibited significant reductions in left ventricular ejection fraction and fractional shortening, along with increased ventricular volume and decreased interventricular septal thickness with cadmium exposure. Interestingly, these changes were not observed in female mice. Further investigation revealed decreased protein expression of sarco/endoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) and phosphorylated phospholamban levels in male hearts with cadmium exposure. These findings provide important insights into the sex-specific effects of cadmium on cardiovascular disease.
Article
Medicine, General & Internal
P. Krisai, P. Hammerle, S. Blum, P. Meyre, S. Aeschbacher, P. Melchiorre-Mayer, O. Baretella, N. Rodondi, D. Conen, S. Osswald, M. Kuhne, C. S. Zuern
Summary: The presence of atrial fibrillation (AF) on a single surface ECG is significantly associated with increased risk of mortality and hospitalizations for congestive heart failure in AF patients, suggesting that these patients are a high-risk group that may benefit from intensified treatment.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Gautam K. Singh, Conor McClenaghan, Manish Aggarwal, Hongjie Gu, Maria S. Remedi, Dorothy K. Grange, Colin G. Nichols
Summary: This study characterizes high-output cardiac hypertrophy in subjects with Cantu syndrome caused by gain-of-function variants in ABCC9, indicating that these patients exhibit significant left ventricular hypertrophy and low blood pressure, which may progress to high-output heart failure.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Vinithra Varadarajan, Samuel S. Gidding, Colin Wu, J. Jeffrey Carr, Joao A. C. Lima
Summary: The increasing prevalence of obesity, hypertension, and diabetes, along with worsening environmental factors, has led to a growing burden of cardiovascular diseases worldwide. Noninvasive imaging techniques, including vascular ultrasound, echocardiography, and magnetic resonance imaging, play a significant role in identifying early cardiovascular disease phenotypes. This article reviews the various imaging modalities used for the evaluation, characterization, and quantification of early subclinical cardiovascular diseases.
CIRCULATION RESEARCH
(2023)
Article
Medicine, General & Internal
Philipp Krisai, Laurent Roten, Ivan Zeljkovic, Nikola Pavlovic, Peter Ammann, Tobias Reichlin, Eric Auf Der Maur, Olivia Streicher, Sven Knecht, Michael Kuhne, Stefan Osswald, Jan Novak, Christian Sticherling
Summary: The study found a high proportion of post-ablation AF in cAFL patients during standardized follow-up, indicating the need for consideration when deciding on long-term oral anticoagulation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Eunice Yang, David Spragg, Steven Schulman, Nisha A. Gilotra, Ahmet Kilic, Rawn Salenger, Glenn Whitman, Thomas S. Metkus
Summary: Rhythm control in HF patients with POAF after cardiac surgery can lead to early restoration of sinus rhythm. Both rate and rhythm control are reasonable options for managing AF in HF patients post-cardiac surgery.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Surgery
Mark E. Taylor, Adam K. McDiarmid, Iain G. Matthews, Jayant Kakarla, Janet M. McComb, Gareth Parry, Stephen W. Lord
Summary: Atrial flutter is a significant late complication post cardiac transplantation, and patients treated with ablation in the modern era had improved survival compared to those managed medically.
CLINICAL TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Yihang Wu, Pengchao Tian, Lin Liang, Yuyi Chen, Jiayu Feng, Boping Huang, Liyan Huang, Xuemei Zhao, Jing Wang, Jingyuan Guan, Xinqing Li, Jian Zhang, Yuhui Zhang
Summary: Cardiac power output (CPO) is a strong predictor of adverse outcomes in heart failure (HF). The prognostic performance of RAP-corrected CPO (CPORAP) is unknown in heart failure with preserved ejection fraction (HFpEF). This study found that CPORAP was more effective than CPO in predicting outcomes in HFpEF patients with pulmonary hypertension.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Mark N. Belkin, Francis J. Alenghat, Stephanie A. Besser, Sean P. Pinney, Jonathan Grinstein
Summary: This study investigated the inclusion of RAP in the derivation of CPO and found that CPO-RAP was significantly associated with the primary outcome.
JOURNAL OF CARDIAC FAILURE
(2022)
Review
Chemistry, Analytical
Chuyu Tang, Zhirong Liu, Linlin Li
Summary: Cardiovascular disease is a leading cause of death worldwide. Monitoring cardiovascular indicators in real-time is crucial for early intervention. Flexible wearable/implantable sensors have attracted significant interest for monitoring vital signs. Mechanical sensors, with their high sensitivity and flexibility, can directly reflect pressure fluctuations in the cardiovascular system. This article introduces recent advances in four types of mechanical sensors for cardiovascular monitoring and discusses the importance and challenges of real-time physiological monitoring in cardiovascular disease treatment.