Article
Immunology
Xiaoyu Gu, Xue Qiao, Simiao Yu, Xiaorui Song, Lingling Wang, Linsheng Song
Summary: CgLSD1 is an important epigenetic regulator in hematopoiesis, playing a key role in regulating hemocyte proliferation in oysters.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhao Lv, Limei Qiu, Weilin Wang, Zhaoqun Liu, Qing Liu, Lingling Wang, Linsheng Song
Summary: This study identified a specific hemocyte population, RGD(+) hemocytes, which exhibit high migration activity in response to pathogen infection and potentially enhance antimicrobial peptide production by highly expressing IL-17s.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Zhicheng Guo, Jiejie Sun, Xiaoqian Lv, Tong Zhang, Hongsheng Yao, Wei Wu, Zhen Xing, Ning Kong, Lingling Wang, Linsheng Song
Summary: Ferroptosis is a form of cell death in vertebrates that is dependent on iron and oxidation, typically mediated by redox-related molecules. In this study, homologues of glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11, xCT) were identified from the oyster Crassostrea gigas (designated as CgGPX4 and CgxCT). The mRNA transcripts of CgGPX4 and CgxCT were found in various tissues, with the highest expression in the haemocytes. Treatment with erastin induced ferroptosis in oyster haemocytes, as evidenced by cell malformation, cell death, mitochondrial atrophy, and changes in gene expression.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Biet Thanh Tran, Keun-Yong Kim, Jung Soo Heo, Su-Jin Park, Hong Keun Park, Youn Hee Choi
Summary: Fecal DNA metabarcoding is a valuable tool for studying diet composition in marine animals, but few studies have focused on bivalves. This pilot study investigated the diet composition of the Pacific oyster Magallana gigas in two aquaculture farms in South Korea. The results showed differences in diet diversity and stability between the two farms and variations over different seasons. Dinoflagellates, diatoms, and green algae were the predominant species, and harmful dinoflagellates were detected in both farms. The study highlights the potential of fecal DNA metabarcoding for providing information on M. gigas diet, aiding in aquaculture management.
Article
Immunology
Zhihao Jia, Shuai Jiang, Mengqiang Wang, Xiudan Wang, Yu Liu, Zhao Lv, Xiaorui Song, Yiqun Li, Lingling Wang, Linsheng Song
Summary: A novel member of DM9 domain containing protein, CgDM9CP-4, was identified from Pacific oyster, shown to be a mannose-specific binding pattern-recognition receptor enriched in hemocytes and gill. Its transcripts level were decreased after various pathogen stimulations. The recombinant protein displayed broad binding spectrum and was mainly expressed in non-phagocytic cells. This suggests its potential role in immune recognition of pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Snezhanna Saydakova, Ksenia Morozova, Olga Snytnikova, Maryana Morozova, Lidiya Boldyreva, Elena Kiseleva, Yuri Tsentalovich, Elena Kozhevnikova
Summary: Dietary composition has a significant impact on human health and can influence the development of complex diseases such as obesity, inflammation, and cancer. This study investigated the effects of major dietary phospholipids (PLs) on the morphology of intestinal epithelial cells in mice subjected to high-dose feeding. The results showed that high levels of PLs caused mitochondrial damage and lipid droplet accumulation, making the mitochondria more vulnerable to respiratory uncoupling. However, these mitochondrial changes did not induce intestinal permeability. It is suggested that caution should be exercised when using PL supplementation in individuals with mitochondrial disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Alfredo Loor, Peter Bossier, Nancy Nevejan
Summary: The study found that Delta mnn9 cells can be efficiently ingested and digested by Pacific oyster spat, serving as a suitable alternative to microalgal diets and potentially improving the growth performance of Pacific oysters.
Article
Chemistry, Medicinal
Xing-Wei Xiang, Hui-Zhen Zheng, Rui Wang, Hui Chen, Jin-Xing Xiao, Bin Zheng, Shu-Lai Liu, Yu-Ting Ding
Summary: Oyster peptides have protective effects on immune regulation and gut microbiota in mice, promoting cytokine secretion and activating the NF-kappa B signaling pathway. Additionally, they modify gut microbiota structure, reduce intestinal damage caused by cyclophosphamide, and may be used as a beneficial ingredient in functional foods for immune regulation.
Article
Physiology
Kaidi Jin, Qianqian Jin, Zhongqiang Cai, Baoyu Huang, Lei Wei, Meiwei Zhang, Wen Guo, Yaqiong Liu, Xiaotong Wang
Summary: Recent studies reveal that retinoic acid receptors have a higher expression level in mollusks, potentially playing a role in development and metabolism. After injection with retinoic acid, both receptors showed elevated expression levels, indicating a potential regulatory mechanism in mollusks. Additionally, the receptors can interact to form a heterodimer complex, suggesting a conserved function in signaling pathways.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qianqian Jin, Chuncao Huo, Wenhao Yang, Kaidi Jin, Shuai Cai, Yanxin Zheng, Baoyu Huang, Lei Wei, Meiwei Zhang, Yijing Han, Xuekai Zhang, Yaqiong Liu, Xiaotong Wang
Summary: This study investigates the effect of all-trans retinoic acid (ATRA) on the transcriptome of the Pacific oyster Crassostera gigas. A total of 586 differentially expressed genes (DEGs) were identified, with ATRA affecting the development, metabolism, reproduction, and immunity of C. gigas. Several tyrosinase genes and Tyr-related genes were upregulated by ATRA, and the DNA-binding activity of the RA receptors CgRAR and CgRXR, as well as their interaction with RAREs in the Tyr-2 promoter, were confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuyang Ma, Runfang Wang, Tietao Zhang, Yunsheng Xu, Suisui Jiang, Yuanhui Zhao
Summary: The study found that HHP treatment improved the water content and texture parameters of oysters, adjusted the fatty acid content, and enhanced the volatile flavor compounds, reducing fishiness and positively impacting on the edible qualities.
Article
Agriculture, Multidisciplinary
Yuyang Ma, Xue Liu, Defu Liu, Zihao Yin, Xinyi Yang, Mingyong Zeng
Summary: This study found that oyster polysaccharides (OPS) can ameliorate hepatic oxidative stress and inflammation induced by a high-fat diet (HFD) by regulating bile acid metabolism and signaling pathways. OPS reduced oxidative stress and inflammation in the liver and increased bile acid content. This study provides a theoretical basis for OPS as a new source of functional food.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Tatsuya Ishida, Hiroyuki Matsui, Yoshikazu Matsuda, Takaki Shimono, Seiji Kanda, Toshimasa Nishiyama, Ryota Hosomi, Kenji Fukunaga, Munehiro Yoshida
Summary: In mice, intake of oyster extract can improve symptoms of chronic colitis, including shortened colonic length, increased spleen weight, and alleviated colonic histopathological damage. Additionally, intake of oyster extract can also improve the diversity of fecal microbiota.
Article
Immunology
Yu Liu, Weilin Wang, Jiejie Sun, Yinan Li, Shasha Wu, Qing Li, Miren Dong, Lingling Wang, Linsheng Song
Summary: In this study, a novel DM9CP-5 protein was identified from the Pacific oyster and found to be highly expressed in the gill. The protein was able to bind various molecules and interact with CgIntegrin, and its activation was shown to regulate the release of proinflammatory factors and defensins through the MAPK pathway.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Food Science & Technology
Tatsuya Ishida, Hiroyuki Matsui, Yoshikazu Matsuda, Ryota Hosomi, Takaki Shimono, Seiji Kanda, Toshimasa Nishiyama, Kenji Fukunaga, Munehiro Yoshida
Summary: This study investigated the effects of oyster extract (OE) on acute experimental colitis in mice. The results showed that OE intake reduced body weight loss, alleviated colon tissue damage, and improved the composition of fecal microbiota and metabolites. These findings provide a basis for the use of OE in alleviating colitis.
Article
Biochemistry & Molecular Biology
Marine Remize, Frederic Planchon, Ai Ning Loh, Fabienne Le Grand, Antoine Bideau, Nelly Le Goic, Elodie Fleury, Philippe Miner, Rudolph Corvaisier, Aswani Volety, Philippe Soudant
Article
Environmental Sciences
Carmen Gonzalez-Fernandez, Fabienne Le Grand, Antoine Bideau, Arnaud Huvet, Ika Paul-Pont, Philippe Soudant
ENVIRONMENTAL POLLUTION
(2020)
Article
Environmental Sciences
Ludovic Hermabessiere, Justine Receveur, Charlotte Himber, David Mazurais, Arnaud Huvet, Fabienne Lagarde, Christophe Lambert, Ika Paul-Pont, Alexandre Dehaut, Ronan Jezequel, Philippe Soudant, Guillaume Duflos
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Nanoscience & Nanotechnology
K. Tallec, I. Paul-Pont, M. Boulais, N. Le Goic, C. Gonzalez-Fernandez, F. Le Grand, A. Bideau, C. Quere, A. -L. Cassone, C. Lambert, P. Soudant, A. Huvet
Article
Environmental Sciences
Karine Salin, Margaux Mathieu-Resuge, Nicolas Graziano, Emmanuel Dubillot, Fabienne Le Grand, Philippe Soudant, Marie Vagner
Summary: Climate change leads to a reduction in crucial nutrient production at the base of the marine food chain, affecting consumers like fish, which rely on n-3 HUFA. This study explores how variations in mitochondrial efficiency are related to fatty acid composition in biological membranes and could explain intraspecific differences in response to diet changes, highlighting the importance of individual differences in mitochondrial efficiency.
MARINE ENVIRONMENTAL RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
K. Tallec, I. Paul-Pont, B. Petton, M. Alunno-Bruscia, C. Bourdon, I. Bernardini, M. Boulais, C. Lambert, C. Quere, A. Bideau, N. Le Goic, A. -L. Cassone, F. Le Grand, C. Fabioux, P. Soudant, A. Huvet
Summary: An experimental study found that exposure of oyster embryos to 50 nm polystyrene nanobeads led to negative effects on larval growth and lipid storage, while no significant impact was observed on adult and second generation larvae. Overall, the study suggests a low incidence of short embryonic exposure to nanoplastics on oyster phenotypes throughout their life cycle.
Article
Biochemistry & Molecular Biology
Valentine Meunier, Laura Geissler, Sophie Bonnet, Nils Raedecker, Gabriela Perna, Olivier Grosso, Christophe Lambert, Riccardo Rodolfo-Metalpa, Christian R. Voolstra, Fanny Houlbreque
Summary: The study revealed that corals adapt to high CO2 conditions by modifying their nitrogen assimilation pathways and increasing feeding on nitrogen-rich picoplankton. This flexible adaptation may help corals cope better in a high pCO2 world.
Article
Chemistry, Medicinal
Marine Remize, Frederic Planchon, Matthieu Garnier, Ai Ning Loh, Fabienne Le Grand, Antoine Bideau, Christophe Lambert, Rudolph Corvaisier, Aswani Volety, Philippe Soudant
Summary: This study investigated the synthesis pathways of polyunsaturated fatty acids (PUFA) in Tisochrysis lutea by tracking the enrichment of a C-13 isotopic marker. The results suggest that T. lutea employs different pathways, including the PKS pathway, to produce PUFA. PKS synthesis appears to be particularly effective in producing long chain PUFA.
Article
Environmental Sciences
Mathilde Bertrand, Pablo Brosset, Philippe Soudant, Christophe Lebigre
Summary: Food characteristics play a significant role in influencing fish life history traits, with changes in diet impacting energy allocation for growth. Recent studies show that European sardines in the Bay of Biscay have experienced a substantial decrease in size and weight, particularly for younger age classes. Differences in fatty acid composition of sardines at different ages and regions suggest variations in diet preferences and prey availability, highlighting the importance of considering separate lipid fractions in future research.
MARINE ENVIRONMENTAL RESEARCH
(2022)
Article
Microbiology
Marion Soree, Francois Delavat, Christophe Lambert, Solen Lozach, Mathias Papin, Bruno Petton, Delphine Passerini, Lionel Degremont, Dominique Hervio Heath
Summary: The study revealed that oysters grown in controlled environments accumulated more Vibrio parahaemolyticus than those grown in intertidal environments, possibly due to immune priming in the latter. However, both types of oysters showed similar depuration rates for V. parahaemolyticus.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Chemistry, Medicinal
Denis de la Broise, Mariana Ventura, Luc Chauchat, Maurean Guerreiro, Teo Michez, Thibaud Vinet, Nicolas Gautron, Fabienne Le Grand, Antoine Bideau, Nelly Le Goic, Adeline Bidault, Christophe Lambert, Philippe Soudant
Summary: This study investigates the feasibility of non-axenic cultivation of Aurantiochytrium mangrovei on industrial substrates and the scale-up of its production. The results show that the production of DHA is viable and competitive under certain conditions. Furthermore, the impact of bacterial contamination on the fatty acid composition of the biomass is minimal, indicating that the biomass can be safely used as feed.
Article
Environmental Sciences
Marc Long, Aurelie Lelong, Eva Bucciarelli, Fabienne Le Grand, Helene Hegaret, Philippe Soudant
Summary: In iron-limited environments, copper deficiency can restrict the growth of phytoplankton species in the open ocean. In this study, the physiological strategies of the marine diatom P. delicatissima against copper starvation were investigated. Despite inhibiting growth by 35%, copper starvation did not induce excess mortality in the diatom. Instead, it adapted by maintaining photosynthesis ability, altering membrane structure, and redirecting carbon allocation to energy storage in the form of triglycerides.
MARINE ENVIRONMENTAL RESEARCH
(2023)
