Review
Cell Biology
Malcolm J. Jackson, Natalie Pollock, Caroline Staunton, Samantha Jones, Anne McArdle
Summary: Research has shown that reactive oxygen species are generated in skeletal muscle during exercise and play important roles in muscle adaptations. This review aims to summarize the current understanding of the redox signaling roles of these species in mediating muscle responses to contractile activity, with a focus on the effects of aging. Additionally, evidence is provided suggesting that disruption of muscle mitochondria's redox status due to age-associated denervation may contribute to a weakening of muscle responses to contractile activity.
Article
Engineering, Biomedical
Gelareh Hajian, Ali Etemad, Evelyn Morin
Summary: This paper explores a force estimation method that is generalizable across individuals using deep convolutional neural networks (CNN) with feature level fusion of high-density EMG data, and the proposed method outperformed other baseline methods.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Physiology
Ernest Baiget, Joshua Colomar, Francisco Corbi
Summary: This study aimed to evaluate the effects of 6 weeks of specific-joint isometric strength training on serve velocity (SV), serve accuracy (SA), and force-time curve variables. The results showed that 6 weeks of upper-limb specific-joint isometric strength training alongside habitual technical-tactical workouts led to significant increases in SV without compromising SA in young tennis players. No changes were observed in the control group.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Sport Sciences
Stuart N. Guppy, Yosuke Kotani, Claire J. Brady, Shannon Connolly, Paul Comfort, G. Gregory Haff
Summary: This study aimed to compare the reliability and magnitude of force-time characteristics between short-duration and traditional isometric mid-thigh pull (IMTP) trials. The findings showed that short-duration trials had higher reliability and greater force and rate of force development. It is important for researchers to choose appropriate testing protocols based on their objectives and be aware of the impact of analysis choices on the results.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2022)
Article
Nutrition & Dietetics
Michael T. Paris, Alexander M. Zero, Charles L. Rice
Summary: The test-retest repeatability of plantar flexion isometric torque and isotonic power evoked using brief tetanic trains at 10 and 50 Hz was evaluated in this study. Both torque and power showed excellent repeatability at low and high frequencies. Similar to isometric torque, electrically evoked isotonic power is a stable measure for studying dynamic muscle function.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Physiology
Javier Rodriguez-Falces, Armando Malanda, Javier Navallas, Nicolas Place
Summary: This study aimed to experimentally assess the changes in the compound muscle action potential (M-wave) caused by brief voluntary and stimulated isometric contractions. Two methods of inducing muscle shortening were used under isometric condition, and the amplitude and duration of the M-wave phases were measured. The results showed that muscle shortening led to a decrease in the amplitude of the first phase and an increase in the amplitude of the second phase of the M-wave.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Sport Sciences
Shigeru Sato, Riku Yoshida, Fu Murakoshi, Yuto Sasaki, Kaoru Yahata, Kazunori Nosaka, Masatoshi Nakamura
Summary: The study compared the effects of 3-s isometric maximal voluntary contraction (MVC), concentric MVC, and eccentric MVC on muscle strength and thickness. It found that performing one 3-s MVC a day can increase muscle strength, with eccentric MVC producing more potent effects than isometric or concentric MVC.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Biophysics
Pooja P. Kanade, Nomin-Erdene Oyunbaatar, Arunkumar Shanmugasundaram, Yun-Jin Jeong, Eung-Sam Kim, Bong-Kee Lee, Dong-Weon Lee
Summary: This study introduces a drug screening platform based on a microelectrode array integrated SU-8 cantilever, which enables simultaneous measurement of electrophysiology and contractility of cardiomyocytes. The feasibility of this platform is verified through drug tests, and it is found that some drugs have greater toxicity to contractility, highlighting the need for a reliable dual measurement platform for assessing cardiotoxicity.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Physiology
Danny Lum, Abdul Rashid Aziz
Summary: The study found that mean power during kayak ergometer tests is a good predictor of completion time in on-water kayak tests. Additionally, both upper- and lower-body maximum strength and peak rate of force development are equally important for sprint kayaking performance on-water and on the ergometer.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2021)
Article
Physiology
Lejun Wang, Xiaoqian Song, Hua Yang, Ce Wang, Qineng Shao, Haifeng Tao, Minjie Qiao, Wenxin Niu, Xiaodong Liu
Summary: This study examined the fatigue of antagonist muscles during a low-force isometric contraction. The results suggest that antagonist muscles may experience peripheral fatigue during prolonged low-force isometric fatiguing contractions. Additionally, changes in coactivation activities are influenced by both central neuronal mechanisms and peripheral metabolic factors.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Mathematics, Applied
Mohamed Amine Aouichaoui, Haikel Skhiri
Summary: This article presents a study on partial isometrics and introduces a new class of operators called N-A-isometries. The basic properties of N-A-isometries are discussed, and various results that improve and extend classical partial isometrics are presented.
ACTA APPLICANDAE MATHEMATICAE
(2022)
Article
Multidisciplinary Sciences
Dawid Kozlenia, Jaroslaw Domaradzki
Summary: This study aimed to examine the effectiveness of isometric post-activation performance enhancement protocols using an external load (EXL) or voluntary effort (VE) on jump height (JH) in trained females. The results showed that both EXL and VE groups improved JH at different time points. The importance of this study is rated 7 out of 10.
SCIENTIFIC REPORTS
(2023)
Article
Sport Sciences
Dustin J. Oranchuk, Adam G. Storey, Andre R. Nelson, Jonathon G. Neville, John B. Cronin
Summary: This study examined the variability of isometric force-time characteristics in trained men at different angles. Results showed that there was low intersession variability in isometric peak force and late-stage isometric RFD and impulse measurements, while early-stage RFD and impulse measures had moderate to large variability.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2022)
Article
Geriatrics & Gerontology
Rita De Gasperi, Chenglin Mo, Daniella Azulai, Zhiying Wang, Lauren M. Harlow, Yating Du, Zachary Graham, Jiangping Pan, Xin-hua Liu, Lei Guo, Bin Zhang, Fred Ko, Ashleigh M. Raczkowski, William A. Bauman, Chris N. Goulbourne, Wei Zhao, Marco Brotto, Christopher P. Cardozo
Summary: This study investigates the role of Numb protein in skeletal muscle structure and function. The expression of Numb is reduced with advanced age in human muscle. Knockout of Numb leads to decreased muscle force, altered mitochondrial structure, delayed calcium transients, and changes in gene expression and lipid mediators. These findings suggest that Numb plays critical roles in skeletal muscle and may contribute to the loss of muscle function observed with sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cell Biology
Michaeljohn Kalakoutis, Ross D. D. Pollock, Norman R. R. Lazarus, R. Andrew Atkinson, Marc George, Onur Berber, Roger C. C. Woledge, Julien Ochala, Stephen D. R. Harridge
Summary: The specific force (SF) of human aging in single muscle fibers is inconsistent in different studies, which may result from variations in the health status/physical activity levels and methodological differences. This study compared SF in fibers from older hip fracture patients, healthy master cyclists, and healthy nontrained young adults using two different activating solutions. The results showed that the activating solution significantly affected the force and revealed a difference in sensitivity in muscle fibers of hip fracture patients.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Joao Ricardhis S. Oliveira, Junaith S. Mohamed, Matthew J. Myers, Matthew J. Brooks, Stephen E. Alway
EXPERIMENTAL GERONTOLOGY
(2019)
Editorial Material
Physiology
Stephen E. Alway
EXERCISE AND SPORT SCIENCES REVIEWS
(2019)
Article
Geriatrics & Gerontology
Matthew J. Myers, Danielle L. Shepherd, Andrya J. Durr, David S. Stanton, Junaith S. Mohamed, John M. Hollander, Stephen E. Alway
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Article
Physiology
Peter J. Ferrandi, Stephen E. Alway, Junaith S. Mohamed
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Cell Biology
Brian T. Bennett, Junaith S. Mohamed, Stephen E. Alway
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Genetics & Heredity
Peter J. Ferrandi, Mohammad Moshahid Khan, Hector G. Paez, Christopher R. Pitzer, Stephen E. Alway, Junaith S. Mohamed
Editorial Material
Physiology
Peter J. Ferrandi, Stephen E. Alway, Junaith S. Mohamed
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Neurosciences
Nidheesh Thadathil, Jianfeng Xiao, Roderick Hori, Stephen E. Alway, Mohammad Moshahid Khan
Summary: The study demonstrated that the brain-selective estrogen prodrug DHED can alleviate the PD-like symptoms induced by MPTP in mice, including behavioral impairments and dopaminergic neurodegeneration. Additionally, DHED was found to reduce levels of inflammation and oxidative stress in the striatum.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Matthew J. Myers, Fathima Shaik, Fahema Shaik, Stephen E. Alway, Junaith S. Mohamed
Summary: The study found that aging affects the role of CR in muscle, with CR restoring global gene expression inhibition caused by aging by upregulating transcriptional and translational process-related pathways. However, CR inhibits pathways related to extracellular matrix and cytoskeletal proteins regardless of aging.
Article
Geriatrics & Gerontology
Stephen E. Alway, Hector G. Paez, Christopher R. Pitzer, Peter J. Ferrandi, Mohammad Moshahid Khan, Junaith S. Mohamed, James A. Carson, Michael R. Deschenes
Summary: This study investigated the effect of mitochondrial transplant therapy (MTT) on the restoration of muscle function after neuromuscular injury. The results showed that MTT can enhance muscle regeneration and restoration of muscle function without increasing systemic inflammation in mice.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Cell Biology
Hector G. G. Paez, Christopher R. R. Pitzer, Stephen E. E. Alway
Summary: Sarcopenia is a skeletal muscle disease characterized by deficits in muscle strength, mass, quality, and metabolic health, which worsens with age. The causes of sarcopenia are complex and involve a combination of environmental factors and intrinsic age-related changes. Loss of muscle quality, rather than just muscle mass, is the primary defect with advanced age. Dysregulation of proteostasis, an important cellular quality control mechanism, is a significant contributor to age-associated declines in muscle quality, function, and mass. Inhibition of the mTORC1 pathway and caloric restriction show promise in improving muscle quality in aged animals, but further research is needed to fully understand the mechanisms involved.
Review
Cell Biology
Christopher R. Pitzer, Hector G. Paez, Stephen E. Alway
Summary: Cancer cachexia is unintentional weight loss associated with poor prognosis. Exosomes, originating from multivesicular bodies, carry biomolecular cargo that can alter cell signaling. They affect muscle and adipose tissue metabolism, macrophage polarization, and apoptosis, contributing to cachexia phenotype. Tumor-derived exosomes have potential as biomarkers and play a role in cancer cachexia progression by affecting skeletal muscle and adipose tissue.
Article
Endocrinology & Metabolism
Jessica L. L. Halle, Brittany R. R. Counts, Hector G. G. Paez, Dryden R. R. Baumfalk, Quan Zhang, Junaith S. S. Mohamed, Evan S. S. Glazer, Melissa J. J. Puppa, Ashley J. J. Smuder, Stephen E. E. Alway, James A. A. Carson
Summary: FOLFOX chemotherapy has acute and lasting effects on systemic and skeletal muscle metabolism, disrupting body weight and metabolic signaling. Recovery is observed in skeletal muscle metabolic signaling, but not in systemic metabolism. Further studies are needed to prevent and treat FOLFOX-induced metabolic toxicities.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Hector G. Paez, Peter J. Ferrandi, Christopher R. Pitzer, Junaith S. Mohamed, Stephen E. Alway
Summary: The study investigates the impact of NOR-1 deficiency on C2C12 metabolic signaling. The results reveal that NOR-1 acts as a modulator of mTORC1 signaling and its deficiency may contribute to insulin resistance and metabolic disease. Therefore, strategies that improve NOR-1 levels could be important in mitigating muscle metabolic abnormalities.
Article
Biochemistry & Molecular Biology
Kiril Tuntevski, Ameena Hajira, Austin Nichols, Stephen E. Alway, Junaith S. Mohamed
