Article
Biochemistry & Molecular Biology
Mandy Laube, Ulrich H. Thome
Summary: Albumin enhances epithelial Na+ transport and barrier integrity by activating the PI3K/AKT/SGK1 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Maxwell P. Bui-Marinos, Lauren A. Todd, Marie-Claire D. Wasson, Brandon E. E. Morningstar, Barbara A. Katzenback
Summary: The study found that Xenopus laevis skin epithelial cells are susceptible and permissive to Frog virus 3 (FV3), but do not exhibit appreciable levels of scavenger receptors needed for FV3 cellular entry. These cells show antiviral and proinflammatory responses to poly(I:C), but not to FV3 or UV-inactivated FV3. Pretreatment with poly(I:C) can limit FV3 replication and cytopathic effects in these cell lines.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Hua-Li Hu, Jia-Meng Chen, Jing-Yi Chen, Rachel Wan Xin Seah, Guo-Hua Ding
Summary: The study revealed significant differences in microbial communities on healthy and ulcerated Hoplobatrachus rugulosus skin, indicating changes in bacterial proportion and type may be caused by skin ulceration. This information could be valuable in developing strategies to combat diseases in H. rugulosus.
Article
Multidisciplinary Sciences
Lauren A. Todd, Maxwell P. Bui-Marinos, Barbara A. Katzenback
Summary: The study identified significant differences in microRNA expression in response to poly(I:C) stimulation in the skin epithelial-like cells of Xenopus laevis, with many microRNAs predicted to target regulators of antiviral pathways. On the other hand, fewer microRNAs were affected by FV3 infection, and these were less likely to interact with antiviral pathways. Interestingly, both poly(I:C) treatment and FV3 infection downregulated transcripts encoding factors of the host microRNA biogenesis pathway.
Article
Chemistry, Multidisciplinary
Yuqi Li, Qiunan Liu, Siyuan Wu, Lin Geng, Jelena Popovic, Yu Li, Zhao Chen, Haibo Wang, Yuqi Wang, Tao Dai, Yang Yang, Haiming Sun, Yaxiang Lu, Liqiang Zhang, Yongfu Tang, Ruijuan Xiao, Hong Li, Liquan Chen, Joachim Maier, Jianyu Huang, Yong-Sheng Hu
Summary: Using in situ environmental transmission electron microscopy combined with theoretical simulations, it is found that the different stabilities of Li and Na in dry air are due to the formation of compact Li2O layers on Li metal and porous and rough Na2O/Na2O2 layers on Na metal. The kinetics of Na can be changed towards an anticorrosive behavior by a preformed carbonate layer. This study enhances the understanding of chemical reactions with environmental gases and improves the electrochemical performance of Li and Na by controlling interfacial stability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Harry C. Blair, Quitterie C. Larrouture, Irina L. Tourkova, Deborah J. Nelson, Steven F. Dobrowolski, Paul H. Schlesinger
Summary: This article reviews the unique properties of bone formation, focusing on the current understanding of mechanisms of bone mineral transport. The bone matrix has specialized mechanisms for continuous transport and deposition of mineral, which is absent in other connective tissues. The specialized proteins that regulate connective tissue structure and formation are surprisingly similar in mineralized and non-mineralized tissues.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Guizhu Feng, Lin Wei, Helong Che, Yan Shen, Jun Yang, Kai Mi, Jin Liu, Jing Wu, Hailong Yang, Lixian Mu
Summary: A novel peptide called antioxidin-NV was identified from the skin of plateau frog Nanorana ventripunctata. It has been found to protect against UVB-induced DNA damage, cell apoptosis, and inflammatory response, thus preventing photoaging.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Viktor N. Tomilin, Kyrylo Pyrshev, Anna Stavniichuk, Naghmeh Hassanzadeh Khayyat, Guohui Ren, Oleg Zaika, Sherif Khedr, Alexander Staruschenko, Fang C. Mei, Xiaodong Cheng, Oleh Pochynyuk
Summary: Epac1 and Epac2 have similar but nonredundant roles in renal sodium handling. Inhibition of Epac signaling could be instrumental in the treatment of hypertensive states associated with ENaC overactivation.
Article
Biology
Daniel J. Paluh, Karina Riddell, Catherine M. Early, Maggie M. Hantak, Gregory F. M. Jongsma, Rachel M. Keeffe, Fernanda Magalhaes Silva, Stuart Nielsen, Maria Camila Vallejo-Pareja, Edward L. Stanley, David C. Blackburn
Summary: Frogs have lost their teeth over 20 times, more than any other vertebrate group, which is associated with their specialized diet and jaw morphology. This provides a unique opportunity to study the molecular and developmental mechanisms of convergent tooth loss.
Article
Physiology
Antonio G. Soares, Jorge Contreras, Crystal R. Archer, Elena Mironova, Rebecca Berdeaux, James D. Stockand, Tarek Mohamed Abd El-Aziz
Summary: The study demonstrates that targeted activation of Gs signaling exclusively in renal principal cells (PC) is sufficient to increase ENaC activity and decrease urinary sodium excretion in live animals.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chaochao Pan, Kruttika S. Phadke, Zheng Li, Gaoyuan Ouyang, Tae-hoon Kim, Lin Zhou, Julie Slaughter, Bryan Bellaire, Shenqiang Ren, Jun Cui
Summary: This article reports on the development of sprayable copper and copper-zinc nanowire inks for antiviral surface coating applications. The results show that copper nanowires can inactivate the SARS-CoV-2 virus faster than bulk copper, and the addition of a trace amount of zinc enhances the virucidal effect. These sprayable nanowire inks can be easily applied on high-touch surfaces and, when combined with chemical disinfectants, extend the disinfecting effect.
Article
Multidisciplinary Sciences
Constantina Theofanopoulou, Gregory Gedman, James A. Cahill, Cedric Boeckx, Erich D. Jarvis
Summary: The study indicates that oxytocin and vasopressin are adjacent paralogous genes that likely resulted from a local duplication through DNA transposable elements near the origin of vertebrates, with vasotocin retaining more of the parental sequence. Six major oxytocin-vasotocin receptors were identified among vertebrates, potentially originating from a single receptor shared with the common ancestor of invertebrates through whole-genome and large segmental duplications.
Review
Dermatology
Jerry Tsai, Mary Rostom, Luis A. Garza
Summary: Palmoplantar skin possesses unique characteristics including increased thickness, high resilience, hypopigmentation, and the absence of hair follicles. The development of palmoplantar identity relies on interactions between keratinocytes and fibroblasts, with the involvement of keratin 9 expression and Wnt signaling. Understanding the process of palmoplantar feature development may facilitate their reproduction in other body sites.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Chemistry, Multidisciplinary
S. K. Vineeth, Chhail Bihari Soni, Yongming Sun, Vipin Kumar, Zhi Wei Seh
Summary: Sodium-metal anode battery technologies have brought significant advancements to energy storage research. New insights have been gained on the composition and stability of the solid electrolyte interphase (SEI) on the sodium-metal anode, with a focus on the impact of electrolyte structure and ion-solvation chemistry. This review discusses the crucial aspects of ion-solvation chemistry on the stability of SEI and highlights future research directions for designing a stable sodium-metal anode.
TRENDS IN CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Qifan Yang, Deliang Chen
Summary: This review focuses on the importance of Na+ pump research, particularly on the structural and functional studies of the light-driven Na+-pumping rhodopsin (NaR). Key areas of investigation include uncovering the translocation pathway of Na+, examining the role of structural changes in the photocycle for Na+ transport, and investigating the timing of Na+ uptake/release.