期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 81, 期 12, 页码 4077-4089出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.00694-15
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资金
- Swiss National Science Foundation [31003A-130723, 31003A_143773, 31003A_153374]
- Swiss National Science Foundation (SNF) [31003A_143773, 31003A_130723, 31003A_153374] Funding Source: Swiss National Science Foundation (SNF)
Members of the genus Burkholderia are versatile bacteria capable of colonizing highly diverse environmental niches. In this study, we investigated the global response of the opportunistic pathogen Burkholderia cenocepacia H111 to nitrogen limitation at the transcript and protein expression levels. In addition to a classical response to nitrogen starvation, including the activation of glutamine synthetase, PII proteins, and the two-component regulatory system NtrBC, B. cenocepacia H111 also upregulated polyhydroxybutyrate (PHB) accumulation and exopolysaccharide (EPS) production in response to nitrogen shortage. A search for consensus sequences in promoter regions of nitrogen-responsive genes identified a sigma(54) consensus sequence. The mapping of the sigma(54) regulon as well as the characterization of a sigma(54) mutant suggests an important role of sigma(54) not only in control of nitrogen metabolism but also in the virulence of this organism.
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