Article
Neurosciences
Bingmin Luo, Jing Li, Jingpeng Liu, Funi Li, Miaoqing Gu, Haoran Xiao, Shujun Lei, Zhongju Xiao
Summary: The brain regions responsible for the formation of auditory threat memory and perceptual decisions remain uncertain. This study used chemogenetic and optogenetic manipulations to investigate the roles of different brain regions in threat memory learning. The results suggest that the temporal association cortex plays a crucial role in auditory threat memory formation, with inputs from A1, A2, and MGm.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Paul Glad Mihai, Nadja Tschentscher, Katharina von Kriegstein
Summary: The study shows that task-dependent modulation in speech recognition increases with sensory uncertainty in the speech signal, particularly in the ventral MGB providing driving input to the auditory cortex for speech in noisy listening conditions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Hang Wu, Dong Wang, Yueyao Liu, Musi Xie, Liwei Zhou, Yiwen Wang, Jin Cao, Yujuan Huang, Mincong Qiu, Pengmin Qin
Summary: Using multivariate pattern analysis and dynamic causal modelling analysis, this study explored the regional activation pattern and inter-region effective connection during the perception of the subject's own name (SON). The findings showed that SON and other names could be distinguished based on the activation pattern in the primary auditory cortex. The study also revealed an excitatory effect of SON on connections from the anterior insula/inferior frontal gyrus to the primary auditory cortex and temporoparietal junction, highlighting the importance of the influence of the insula on the primary auditory cortex during self-processing.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Alex T. L. Leong, Eddie C. Wong, Xunda Wang, Ed X. Wu
Summary: Using optogenetics and functional MRI in rodents, this study investigates how hippocampal activity modulates sound-evoked responses in the auditory midbrain and thalamus. Stimulation of ventral hippocampus excitory neurons enhances auditory responses to natural vocalizations but not to artificial sounds or noise. Pharmacological inactivation of the ventral hippocampus diminishes response selectivity to vocalizations. These findings reveal the importance of hippocampus in sound processing at early centers of the ascending auditory pathway.
Article
Psychiatry
Kangkang Xue, Jingli Chen, Yarui Wei, Yuan Chen, Shaoqiang Han, Caihong Wang, Yong Zhang, Xueqin Song, Jingliang Cheng
Summary: This research used resting state functional magnetic resonance imaging (rs-fMRI) to study schizophrenia patients and found that those with auditory verbal hallucination (AVH) showed abnormal dynamic functional connectivity (dFC) in auditory related regions, mainly involving the occipital lobe, default mode network (DMN), and middle temporal lobe. These findings provide insights into the neurological mechanism of AVH in schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Jonathan Z. Simon, Vrishab Commuri, Joshua P. Kulasingham
Summary: The primary auditory cortex plays a critical role in the human auditory pathway, but non-invasive physiological recordings may not accurately separate its responses from subcortical or neighboring cortical areas. Recent advances have made it easier to isolate the neural activity of the primary auditory cortex. By focusing on time-locked responses and high gamma band stimulus features, researchers can better understand the effects of top-down processing on the primary auditory cortex.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Faris Almasabi, Gusta van Zwieten, Faisal Alosaimi, Jasper V. Smit, Yasin Temel, Marcus L. F. Janssen, Ali Jahanshahi
Summary: Tinnitus, the phantom perception of sound, currently lacks effective curative treatment. Deep brain stimulation has been suggested as a potential therapy, but the optimal target and stimulation regimens are still unclear. This study investigated metabolic and neuronal activity changes in a rat model of tinnitus and found alterations in multiple brain areas, including the auditory and limbic regions. The study also demonstrated that high-frequency stimulation of the medial geniculate body enhanced neuronal activity in the thalamic reticular nucleus. These findings provide further rationales for targeting the medial geniculate body with high-frequency stimulation as a symptom management tool in tinnitus.
Article
Neurosciences
Carlos Silva, Blake S. Porter, Kristin L. Hillman
Summary: Animals must continually assess effort and physiological states during tasks, with the ACC and anterior insular cortex implicated in cost-benefit decision-making. Contrary to predictions, stimulation of Cg1 did not increase persistence in the task, while stimulation of the anterior insula had little effect on effortful behavior.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Xiaohui Wang, Yuanqing Zhang, Lin Zhu, Siyi Bai, Rui Li, Hao Sun, Runze Qi, Ruolan Cai, Min Li, Guoqiang Jia, Xinyuan Cao, Kenneth E. Schriver, Xinjian Li, Lixia Gao
Summary: Cortical feedback is crucial for sensory perception and recognition. However, previous studies have found varying effects of the primary auditory cortex (A1) on subcortical neurons' auditory response, making it difficult to interpret the function of A1 in sound perception. This study used cryo-inactivation in A1 to investigate corticothalamic feedback on medial geniculate body (MGB) neurons in awake marmosets. The results showed that A1 inactivation led to a frequency-specific decrease in MGB neurons' auditory response and an increase in spontaneous firing rate, resulting in a decreased signal-to-noise ratio. Additionally, A1 was found to modulate the sustained response of MGB neurons and change their frequency tuning.
Article
Neurosciences
Aldis P. Weible, Michael Wehr
Summary: The research found that amyloid pathology in 5XFAD mice starts with intracellular accumulation of A beta(42) in the primary auditory cortex (A1) before progressing to extracellular plaques in A1 and other central auditory system regions. Gap detection deficits in 5XFAD mice appear earlier than cognitive deficits and may be related to the accumulation of A beta(42).
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Neurosciences
Mark Hallett
Summary: Pandya made important contributions to the understanding of cortical auditory pathways in 1969, particularly in regards to the observations on transcallosal connections of the primary auditory cortex. His speculation on the role of spatial localization of sound was later found to be incorrect, although the original observation remains valid based on subsequent literature review.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Magdalena Solyga, Tania Rinaldi Barkat
Summary: This study reveals distinct processing of spectrally simple and complex sounds in the two primary auditory cortices in mice, with A1 neurons responding stronger and faster to spectrally complex tones than AAF neurons. Laminar analysis demonstrates a stronger response of A1 neurons in layer 2/3 to spectrally complex tones compared to neurons in layer 4, indicating important transformation in spectral complexity representation within A1.
Article
Neurosciences
Giovana Benassi-Cezar, Isabela Miranda Carmona, Daniela Baptista-de-Souza, Ricardo Luiz Nunes-de-Souza, Azair Canto-de-Souza
Summary: The study found that cohabitation with a conspecific suffering from chronic pain affects the anxiety levels of mice, with changes in neuronal activation observed in the anterior cingulate and insular cortices. Injecting a synaptic blocker in these brain areas can reverse the anxiety-inducing effect caused by cohabitation with a conspecific in chronic pain.
Article
Neurosciences
Faris Almasabi, Marcus L. F. Janssen, Jana Devos, Michelle Moerel, Michael Schwartze, Sonja A. Kotz, Ali Jahanshahi, Yasin Temel, Jasper Smit
Summary: Tinnitus is an auditory sensation that occurs in the absence of actual external stimulation. The lack of successful treatment options for tinnitus is partly due to limited understanding of its mechanisms. Recent research has shown that the auditory thalamus plays a central role in the neuropathophysiology of tinnitus. Changes in thalamic activity and structure have been observed in both animal models and clinical studies. Based on these findings, a potential neuromodulatory treatment option for tinnitus is proposed.
Article
Neurosciences
Yujiao Yang, Dong Chen, Jing Wang, Jie Wang, Zhaofen Yan, Qinqin Deng, Liping Zhang, Guoming Luan, Mengyang Wang, Tianfu Li
Summary: This study aimed to investigate the dynamic coupling between the anterior cingulate cortex (ACC) and anterior insular cortex (AIC) during seizures. The results showed that the functional connectivity and excitability between these two brain regions significantly increased at seizure onset. By analyzing the connectivity and excitability, the seizure-onset zone (SOZ) in ACC and AIC can be identified.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Masataka Nishimura, Hiroyuki Sawatari, Makoto Takemoto, Wen-Jie Song
NEUROSCIENCE RESEARCH
(2015)
Article
Cell Biology
Meikui Wu, Makoto Takemoto, Makoto Taniguchi, Toru Takumi, Toshiro Okazaki, Wen-Jie Song
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2016)
Article
Anatomy & Morphology
Huan Luo, Kayoko Hasegawa, Mingsheng Liu, Wen-Jie Song
FRONTIERS IN NEUROANATOMY
(2017)
Article
Pharmacology & Pharmacy
Meikui Wu, Makoto Takemoto, Huan Luo, Jian-Jun Xu, Mei-Hong Lu, Masaki Kameyama, Toru Takumi, Wen-Jie Song
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Neurosciences
Mei-Hong Lu, Makoto Takemoto, Ken Watanabe, Huan Luo, Masataka Nishimura, Masato Yano, Hidekazu Tomimoto, Toshiro Okazaki, Yuichi Oike, Wen-Jie Song
JOURNAL OF PHYSIOLOGY-LONDON
(2012)
Article
Neurosciences
Masataka Nishimura, Wen-Jie Song
Article
Multidisciplinary Sciences
Masataka Nishimura, Chi Wang, Reika Shu, Wen-Jie Song
SCIENTIFIC REPORTS
(2020)
Article
Audiology & Speech-Language Pathology
Feifan Chen, Makoto Takemoto, Masataka Nishimura, Ryohei Tomioka, Wen-Jie Song
Summary: This study compared the postnatal development of A1 and AAF in the rodent auditory cortex, revealing a rapid maturation of tonotopy, slow maturation of response latency and response duration, and a dorsal-to-ventral order of functional maturation.
Article
Neurosciences
Masataka Nishimura, Wen-Jie Song
Summary: This study examined the sensitivity to millisecond latency differences in the primary auditory cortex (A1) using guinea pigs as subjects. The results showed that the high-frequency region of A1 had a linear relationship between millisecond latency differences and nonlinear integration effects, while the low-frequency region did not show significant sensitivity to millisecond differences.
Article
Anatomy & Morphology
Masataka Nishimura, Makoto Takemoto, Wen-Jie Song
BRAIN STRUCTURE & FUNCTION
(2018)