期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 520, 期 12, 页码 2697-2711出版社
WILEY
DOI: 10.1002/cne.23067
关键词
dendritic spine; synaptic vesicle; actin; PSD; active zone; exocytosis
资金
- National Institutes of Health [R01 NS039444, NS35527, P01 GM066311, P41 RR004050, R01 GM82949]
- Branfman Family Foundation
Synaptic function depends on interactions among sets of proteins that assemble into complex supramolecular machines. Molecular biology, electrophysiology, and live-cell imaging studies have provided tantalizing glimpses into the inner workings of the synapse, but fundamental questions remain regarding the functional organization of these nano-machines.'' Electron tomography reveals the internal structure of synapses in three dimensions with exceptional spatial resolution. Here we report results from an electron tomographic study of axospinous synapses in neocortex and hippocampus of the adult rat, based on aldehyde-fixed material stabilized with tannic acid in lieu of postfixation with osmium tetroxide. Our results provide a new window into the structural basis of excitatory synaptic processing in the mammalian brain. J. Comp. Neurol. 520: 2697-2711, 2012. (C) 2012 Wiley Periodicals, Inc.
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