Article
Geriatrics & Gerontology
Mark G. Baxter, Mary T. Roberts, Jeffrey A. Roberts, Peter R. Rapp
Summary: Aged rhesus monkeys, like aged humans, show declines in cognitive function. Cognitive test data from a large sample of male and female rhesus monkeys demonstrate that aged monkeys perform worse than young monkeys on multiple cognitive tasks and that cognitive aging is independent in task domains dependent on different brain regions. Sex and chronological age are not reliable predictors of individual differences in cognitive outcome among the aged monkeys.
NEUROBIOLOGY OF AGING
(2023)
Article
Geriatrics & Gerontology
Tara L. Moore, Damon A. Young, Ronald J. Killiany, Kari R. Fonseca, Dmitri Volfson, David L. Gray, Rita Balice-Gordon, Rouba Kozak
Summary: Age-related declines in cognition, especially in working memory and executive function, are mediated by the prefrontal cortex and the dopamine system within it. Administering the DA D1 R agonist PF-6294 to aged female rhesus monkeys improved memory span on the Delayed Recognition Span Task, particularly on repeated trials.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Min Zhu, Guangneng Liao, Xiaohong Liu, Xu Luo, Gen Chen, Lingyun Wang, Chengshi Wang, Wen Liu, Xin Zeng, Yanrong Lu, Guang Yang, Jingqiu Cheng, Younan Chen
Summary: The loss of beta cell mass and function in aged population is closely related to the prevalence of Type 2 diabetes. This study focuses on the causal relations between aging and age-related pancreatic islets degeneration using rhesus monkeys as an animal model. The findings indicate that the decreased islet size, compromised insulin secretion, and loss of beta cell identity markers are key molecular changes in islet senescence.
Article
Immunology
Ruilian Jia, Xi Wen, Yaqiong Guo, Lihua Xiao, Yaoyu Feng, Na Li
Summary: Nonhuman primates are an important source of parasitic zoonoses. A study in Guiyang, China, revealed a high prevalence of Cryptosporidium in rhesus monkeys in 2010. However, after public health interventions, the detection rate and genetic diversity of Cryptosporidium decreased significantly, with a switch in subtype occurrence.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Augusto Peluso, Mads V. Damgaard, Marcelo A. S. Mori, Jonas T. Treebak
Summary: This review examines the levels of NAD(+) in different species and investigates whether overall NAD(+) levels decrease with aging. The evidence to support this claim is limited, especially in humans, where NAD(+) levels during aging are poorly characterized. Larger studies are needed to assess how NAD(+) levels develop with aging in various tissues.
Review
Cell Biology
Rui Zhou, Shufang Qian, William C. S. Cho, Jinyun Zhou, Chentao Jin, Yan Zhong, Jing Wang, Xiaohui Zhang, Zhoujiao Xu, Mei Tian, Lawrence W. C. Chan, Hong Zhang
Summary: Aging affects gut microbiota compositions, microglia, and cognition abilities, and is recognized as a risk factor for neurodegenerative diseases. The communication between gut microbiota and microglia plays a crucial role in age-related cognitive declines. This review discusses the changes in gut microbiota compositions, brain changes, especially morphology and functions of microglia, and highlights the role of microbiota-microglia connections in neurodegenerative diseases.
Article
Multidisciplinary Sciences
Lars Nyberg, Fredrik Magnussen, Anders Lundquist, William Baare, David Bartres-Faz, Lars Bertram, C. J. Boraxbekk, Andreas M. Brandmaier, Christian A. Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N. Henson, Carme Junque, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Brenda W. J. H. Penninx, Sara Pudas, Oystein Sorensen, Lidia Vaque-Alcazar, Kristine B. Walhovd, Anders M. Fjell
Summary: Despite the modest association between education and cortical volume, higher education does not influence the rates of brain aging. The findings challenge the assumption that education slows down brain aging.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Li Yan, Chen Bai, Yu Zheng, Xiaodong Zhou, Mingxi Wan, Yujin Zong, Shanshan Chen, Yin Zhou
Summary: Super-resolution imaging technology provides higher resolution and signal-to-noise ratio in intracranial microvessel imaging compared to conventional imaging, making it suitable for imaging in large animals and serving as an important experimental basis for the clinical application of non-invasive transcranial ultrasound.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biology
Paul Shin, Qi Pian, Hidehiro Ishikawa, Gen Hamanaka, Emiri T. Mandeville, Shuzhen Guo, Buyin Fu, Mohammed Alfadhel, Srinivasa Rao Allu, Ikbal Sencan-Egilmez, Baoqiang Li, Chongzhao Ran, Sergei A. Vinogradov, Cenk Ayata, Eng Lo, Ken Arai, Anna Devor, Sava Sakadzic, Daniel Henrion
Summary: Aging is a risk factor for cognitive impairment. Aerobic exercise benefits brain function and may promote cognitive health in older adults. This study found that aerobic exercise can improve cerebral microcirculation and cognitive function in aging individuals.
Article
Geriatrics & Gerontology
Pankaja Desai, Kristin R. Krueger, Carlos Mendes de Leon, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan
Summary: This study investigates the impact of depressive symptoms and glial fibrillary acid protein (GFAP) concentrations on cognitive functioning. The results show that depressive symptoms and high GFAP concentrations contribute to cognitive decline, while depressive symptoms and low GFAP concentrations have a smaller effect.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Maud M. van Dinther, Astrid E. Hooghiemstra, Esther Bron, Adriaan E. Versteeg, Anna Leeuwis, Tugba E. Kalay, Justine Moonen, Sanne H. Kuipers, Walter Backes, Jacobus F. A. Jansen, Mathias J. P. van Osch, Geert-Jan Biessels, Julie J. Staals, Robert van Oostenbrugge, Heart-Brain Connection consortium
Summary: Impaired cerebral blood flow (CBF) at baseline is associated with faster cognitive decline in VCI and normal aging. Our results suggest that low CBF precedes and contributes to the development of vascular cognitive impairment. CBF determined by ASL might be used as a biomarker to monitor disease progression or treatment responses in VCI.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Yang Zhou, Monica K. Chawla, Jose L. Rios-Monterrosa, Lingzhi Wang, Marc A. Zempare, Victor J. Hruby, Carol A. Barnes, Minying Cai
Summary: The study found significant correlations between the expression of MCR subtypes in the frontal cortex/hypothalamus and hippocampus regions and the performance of spatial learning and memory in aged rats, supporting the hypothesis that aging has a direct impact on MCR expression and function.
Article
Clinical Neurology
Kacie D. Deters, Elizabeth C. Mormino, Lei Yu, Michael W. Lutz, David A. Bennett, Lisa L. Barnes
Summary: The study investigated the effects of APOE-TOMM40-'523 haplotypes on cognitive decline in non-demented non-Hispanic Blacks (NHB) and compared these effects to non-Hispanic Whites (NHW). Results showed that the '523-S/S haplotype had different effects on cognitive decline in NHB depending on APOE allele, and that differences in the effect of epsilon 4-'523-S in NHB may explain previous mixed findings on epsilon 4 and decline in this population.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Anders M. Fjell, Oystein Sorensen, Inge K. Amlien, David Bartres-Faz, Andreas M. Brandmaier, Nikolaus Buchmann, Ilja Demuth, Christian A. Drevon, Sandra Duezel, Klaus P. Ebmeier, Paolo Ghisletta, Ane-Victoria Idland, Tim C. Kietzmann, Rogier A. Kievit, Simone Kuehn, Ulman Lindenberger, Fredrik Magnussen, Didac Macia, Athanasia M. Mowinckel, Lars Nyberg, Claire E. Sexton, Cristina Sole-Padulles, Sara Pudas, James M. Roe, Donatas Sederevicius, Sana Suri, Didac Vidal-Pineiro, Gerd Wagner, Leiv Otto Watne, Rene Westerhausen, Eniko Zsoldos, Kristine B. Walhovd
Summary: The study found that self-reported sleep quality and sleep disturbances were associated with thinning of the right lateral temporal cortex, with this association becoming more pronounced with age. Sleep disturbances were particularly evident after 60 years, especially in regions with high expression of genes related to oligodendrocytes and S1 pyramidal neurons.
Article
Geriatrics & Gerontology
Steven Dash, Byung Park, Christopher D. Kroenke, William D. Rooney, Henryk F. Urbanski, Steven G. Kohama
Summary: This study found that the rhesus macaque, a long-lived nonhuman primate with a brain structure similar to humans, can serve as a valuable animal model for studying human brain aging. By conducting magnetic resonance imaging scans on 66 macaques, the researchers observed changes in brain structures in older animals, such as enlargement of the lateral ventricles and volume reductions in the frontal cortex, caudate, putamen, hypothalamus, and thalamus. Additionally, there were differences between males and females in both white and gray matter regions. The rhesus macaque presents an ideal model for studying the onset and mitigation of neurodegenerative diseases.
NEUROBIOLOGY OF AGING
(2023)
Article
Clinical Neurology
Johanna L. Crimins, Anne B. Rocher, Alan Peters, Penny Shultz, Jada Lewis, Jennifer I. Luebke
ACTA NEUROPATHOLOGICA
(2011)
Article
Pathology
Katherine J. Kopeikina, George A. Carlson, Rose Pitstick, Adam E. Ludvigson, Alan Peters, Jennifer I. Luebke, Robert M. Koffie, Matthew P. Frosch, Bradley T. Hyman, Tara L. Spires-Jones
AMERICAN JOURNAL OF PATHOLOGY
(2011)
Article
Behavioral Sciences
Tara L. Moore, Stephen P. Schettler, Ronald J. Killiany, Douglas L. Rosene, Mark B. Moss
BEHAVIORAL NEUROSCIENCE
(2009)
Review
Neurosciences
Jennifer Luebke, Helen Barbas, Alan Peters
BRAIN RESEARCH REVIEWS
(2010)
Article
Anatomy & Morphology
Adam E. Ludvigson, Jennifer I. Luebke, Jada Lewis, Alan Peters
BRAIN STRUCTURE & FUNCTION
(2011)
Article
Neurosciences
Laura B. Ngwenya, Douglas L. Rosene, Alan Peters
Article
Neurosciences
Alan Peters, Claire Sethares, Mark B. Moss
JOURNAL OF COMPARATIVE NEUROLOGY
(2010)
Article
Neurosciences
Michael P. Bowley, Howard Cabral, Douglas L. Rosene, Alan Peters
JOURNAL OF COMPARATIVE NEUROLOGY
(2010)
Editorial Material
Neurosciences
Alan Peters, Claire Folger
JOURNAL OF COMPARATIVE NEUROLOGY
(2013)
Article
Neurosciences
Daniel A. Kirschner, Robin L. Avila, Rodolfo E. Gamez Sazo, Adrienne Luoma, Gaby U. Enzmann, Deepika Agrawal, Hideyo Inouye, Mary Bartlett Bunge, Jeffery Kocsis, Alan Peters, Scott R. Whittemore
JOURNAL OF NEUROSCIENCE RESEARCH
(2010)
Review
Geriatrics & Gerontology
Alan Peters, Thomas Kemper
NEUROBIOLOGY OF AGING
(2012)
Editorial Material
Clinical Neurology
Ronald J. Killiany
Article
Neurosciences
J. J. Soghomonian, C. Sethares, A. Peters
Review
Anatomy & Morphology
Alan Peters
FRONTIERS IN NEUROANATOMY
(2009)