Article
Multidisciplinary Sciences
Beatriz Bano-Otalora, Franck Martial, Court Harding, David A. Bechtold, Annette E. Allen, Timothy M. Brown, Mino D. C. Belle, Robert J. Lucas
Summary: The study reveals an impact of daytime light intensity on SCN physiology and the amplitude of circadian rhythms, with lower daytime irradiance leading to a marked reduction in the amplitude of spontaneous activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Deborah A. M. Joye, Kayla E. Rohr, Kimberlee Suenkens, Alissa Wuorinen, Thomas Inda, Madeline Arzbecker, Emma Mueller, Alec Huber, Harshida Pancholi, Murray G. Blackmore, Vania Carmona-Alcocer, Jennifer A. Evans
Summary: Daily and annual changes in light are processed by central clock circuits. The role of somatostatin (SST) in the response of the suprachiasmatic nucleus (SCN) to light has not been examined. Our study shows that SST signaling regulates daily rhythms in behavior and SCN function, with sex-specific effects. Lack of SST signaling increases circadian plasticity and eliminates sex differences in photic responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Takashi Maejima, Yusuke Tsuno, Shota Miyazaki, Yousuke Tsuneoka, Emi Hasegawa, Md Tarikul Islam, Ryosuke Enoki, Takahiro J. Nakamura, Michihiro Mieda
Summary: The study found that specific deletion of vesicular GABA transporter in AVP neurons led to significant impairment of circadian rhythm and disruption of GABA-mediated synaptic transmission in SCN neurons. While molecular circadian oscillations among SCN neurons did not significantly change, there were significant alterations in the phase relationships between molecular clocks and circadian behavioral activities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Arthur H. Cheng, Samuel W. Fung, Sara Hegazi, Osama Hasan Mustafa Hasan Abdalla, Hai-Ying Mary Cheng
Summary: The hypothalamic suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker, and the transcription factor Sox2 plays a crucial role in controlling the expression of circadian neuropeptides and transcription factors in the embryonic SCN. Sox2 deficiency leads to reduced survival of SCN neurons during the postnatal period, but does not affect progenitor cell proliferation or SCN specification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Qiang Liu, Benjamin J. Bell, Dong Won Kim, Sang Soo Lee, Mehmet F. Keles, Qili Liu, Ian D. Blum, Annette A. Wang, Elijah J. Blank, Jiali Xiong, Joseph L. Bedont, Anna J. Chang, Habon Issa, Jeremiah Y. Cohen, Seth Blackshaw, Mark N. Wu
Summary: This study reveals the role of a clock-output molecule in reducing arousal circuit excitability during the active phase, suggesting a multifaceted role for the circadian clock in regulating arousal.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Hester C. van Diepen, Robin A. Schoonderwoerd, Ashna Ramkisoensing, Jan A. M. Janse, Samer Hattar, Johanna H. Meijer
Summary: The study reveals the significant role of cone photoreceptors in regulating circadian rhythms, transmitting light information to the suprachiasmatic nuclei, and affecting their electrical activity levels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Andrew P. Patton, Emma L. Morris, David McManus, Huan Wang, Yulong Li, Jason W. Chin, Michael H. Hastings
Summary: The hypothalamic suprachiasmatic nucleus (SCN) is the master mammalian circadian clock. GABA plays a role in circuit-level timekeeping of SCN neurons, despite the inhibitory effect of increased neuronal firing. The astrocytic clocks in SCN maintain the circadian clockwork by controlling GABAergic inhibition.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Claudia Coomans, Dirk-Jan Saaltink, Tom Deboer, Mayke Tersteeg, Suzanne Lanooij, Anne Fleur Schneider, Aat Mulder, Jan van Minnen, Carolina Jost, Abraham J. Koster, Erno Vreugdenhil
Summary: The newly identified plasticity protein DCL is specifically expressed in the shell of the mouse suprachiasmatic nucleus and is involved in neuroplastic events that require rearrangements of the microtubule cytoskeleton for dynamic cell movement. DCL-positive astrocytes envelop AVP-expressing cells in the SCN, suggesting a role in astrocytic plasticity in regulating circadian rhythms and potentially influencing AVP biosynthesis.
Article
Neurosciences
Futaba Matsui, Sho T. T. Yamaguchi, Riho Kobayashi, Shiho Ito, Sakimi Nagashima, Zhiwen Zhou, Hiroaki Norimoto
Summary: Microglia, the macrophages in the brain, are not involved in the generation and light entrainment of circadian rhythms of behavior, as their depletion does not alter behavioral circadian rhythms. This suggests that the circadian rhythms of locomotor activity is unlikely to be produced by microglia.
Review
Biochemistry & Molecular Biology
Noboru Imai
Summary: Migraine, a type of primary headache, exhibits circadian and circannual rhythms in attack onset, which involve the hypothalamus and melatonin. The prophylactic effect of melatonin in migraines is still controversial. Meanwhile, calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide (PACAP) play important roles in the pathophysiology and treatment of migraines by regulating circadian entrainment to light and could be potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Frederik Elberling, Stefan Spulber, Raj Bose, Hoi Yee Keung, Virpi Ahola, Zongli Zheng, Sandra Ceccatelli
Summary: The present study aimed to investigate the long-term effects of prenatal exposure to the synthetic glucocorticoid analog dexamethasone (Dex) in adult female offspring. The study found that Dex-exposed females were more active and re-entrained slower than controls, while Dex-exposed males were less active and re-entrained faster. Following a phase shift, control females displayed transient reorganization of behavior in light, while Dex-exposed females showed limited variations in both light and dark, suggesting weaker photic entrainment. RNA sequencing in the suprachiasmatic nucleus (SCN) identified downregulated dopamine signaling and upregulated glutamate and GABA signaling in Dex-exposed females, consistent with ADHD models.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Cell Biology
Raymond E. A. Sanchez, Franck Kalume, Horacio O. de la Iglesia
Summary: Nearly all mammals have robust daily rhythms called circadian rhythms, which are controlled by a master clock in the hypothalamus and affect various biological processes. This review summarizes the current understanding of circadian regulation of sleep, including neural circuitry, molecular mechanisms, and developmental regulation.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Behavioral Sciences
Max de Leeuw, Sanne I. Verhoeve, Nic J. A. van der Wee, Albert M. van Hemert, Erno Vreugdenhil, Claudia P. Coomans
Summary: Circadian rhythms are closely related to depression, and disruption of circadian rhythms may contribute to the development of depression. A better understanding of the connection between disturbed circadian rhythms and the etiology of depression could lead to novel therapeutic and preventative strategies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Kolter Grigsby, Courtney Ledford, Tanvi Batish, Snigdha Kanadibhotla, Delaney Smith, Evan Firsick, Alexander Tran, Kayla Townsley, Kaylee-Abril Vasquez Reyes, Katherine LeBlanc, Angela Ozburn
Summary: Previous studies have shown that circadian genes play a role in regulating alcohol intake and harmful alcohol use can alter circadian rhythms. This study aimed to investigate the effects of chronic binge-like drinking on diurnal circadian gene expression patterns in specific brain regions relevant to circadian biology and alcohol intake. The findings suggest that binge-like drinking reduces the amplitude of core circadian clock genes in certain brain regions, providing important insights for the development of pharmacotherapies to reduce harmful drinking and mitigate alcohol's effects on circadian gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Masahiro Matsuo, Kazuyuki Seo, Naoki Mizuguchi, Fumiyoshi Yamazaki, Shoichi Urabe, Naoto Yamada, Masao Doi, Keiko Tominaga, Hitoshi Okamura
Summary: The alpha 2 delta 3 protein plays a crucial role in synchronized cellular oscillations in the suprachiasmatic nucleus (SCN) and contributes to enhancing the sustainability of circadian rhythms in behavior. Mice lacking alpha 2 delta 3 showed severely impaired circadian locomotor activity rhythms under constant light conditions but exhibited normal behavior under constant dark conditions.
Article
Clinical Neurology
Chiara La Morgia, Fred N. Ross-Cisneros, Yosef Koronyo, Jens Hannibal, Roberto Gallassi, Gaetano Cantalupo, Luisa Sambati, Billy X. Pan, Kevin R. Tozer, Piero Barboni, Federica Provini, Pietro Avanzini, Michele Carbonelli, Annalisa Pelosi, Helena Chui, Rocco Liguori, Agostino Baruzzi, Maya Koronyo-Hamaoui, Alfredo A. Sadun, Valerio Carelli
ANNALS OF NEUROLOGY
(2016)
Article
Neurosciences
Jens Hannibal, Anders Tolstrup Christiansen, Steffen Heegaard, Jan Fahrenkrug, Jens Folke Kiilgaard
JOURNAL OF COMPARATIVE NEUROLOGY
(2017)
Article
Endocrinology & Metabolism
J. Fahrenkrug, B. Georg, J. Hannibal, H. L. Jorgensen
JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Casper Schwartz Riedel, Birgitte Georg, Henrik L. Jorgensen, Jens Hannibal, Jan Fahrenkrug
JOURNAL OF MOLECULAR NEUROSCIENCE
(2018)
Article
Dermatology
C. S. Haak, J. Hannibal, U. Paasch, R. R. Anderson, M. Haedersdal
LASERS IN SURGERY AND MEDICINE
(2017)
Article
Cell Biology
Birgitte Georg, Anna Ghelli, Carla Giordano, Fred N. Ross-Cisneros, Alfredo A. Sadun, Valerio Carelli, Jens Hannibal, Chiara La Morgia
Article
Biochemistry & Molecular Biology
Andrea S. Bordt, Ye Long, Nobuo Kouyama, Elizabeth S. Yamada, Jens Hannibal, David W. Marshak
Article
Ophthalmology
Jan Fahrenkrug, Birgitte Georg, Jens Hannibal, Henrik Lovendahl Jorgensen
EXPERIMENTAL EYE RESEARCH
(2018)
Article
Neurosciences
Anders Tolstrup Christiansen, Jens Folke Kiilgaard, Kristian Klemp, David Paul Drucker Woldbye, Jens Hannibal
JOURNAL OF COMPARATIVE NEUROLOGY
(2018)
Article
Multidisciplinary Sciences
Jens Hannibal, Birgitte Georg, Jan Fahrenkrug
Article
Neurosciences
Jens Hannibal, Tania H. B. Norn, Birgitte Georg, Jan Fahrenkrug
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Casper Schwartz Riedel, Birgitte Georg, Jan Fahrenkrug, Jens Hannibal
Article
Multidisciplinary Sciences
Ching-Yan Chloe Yeung, Frank Dondelinger, Erwin M. Schoof, Birgitte Georg, Yinhui Lu, Zhiyong Zheng, Jingdong Zhang, Jens Hannibal, Jan Fahrenkrug, Michael Kjaer
Summary: This study demonstrates the circadian regulation of protein cargo in small extracellular vesicles released by tendon fibroblasts. The abundance of individual proteins in these vesicles shows a 24-hour rhythmic pattern, and the release of vesicles enriched in different protein types is temporally separated. The protein sorting mechanism in the exosome biogenesis pathway, regulated by flotillin-1, plays a role in regulating the abundance of matrix metalloproteinase 14 in tendon fibroblast small extracellular vesicles.
Article
Ophthalmology
Elisabeth Anne Obara, Jens Hannibal, Steffen Heegaard, Jan Fahrenkrug
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Article
Dermatology
S. Sasaki, J. Watanabe, H. Ohtaki, M. Matsumoto, N. Murai, T. Nakamachi, J. Hannibal, J. Fahrenkrug, H. Hashimoto, H. Watanabe, H. Sueki, K. Honda, A. Miyazaki, S. Shioda
BRITISH JOURNAL OF DERMATOLOGY
(2017)