Article
Neurosciences
Bi-Xin Zheng, Ayma Malik, Ming Xiong, Alex Bekker, Yuan-Xiang Tao
Summary: Neuropathic pain is a common clinical disorder that significantly impacts patient quality of life and imposes a substantial economic and social burden. Opioids are currently the last resort for treatment, but their effectiveness is limited due to downregulation of opioid receptors in primary afferent neurons after peripheral nerve trauma. Recent studies have shown that epigenetic modifications, transcription factor expression changes, and alterations in post-translational processing may contribute to this downregulation of opioid receptors in nerve trauma-related dorsal root ganglion neurons. Understanding these molecular mechanisms could offer new approaches for preventing or treating neuropathic pain.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Pharmacology & Pharmacy
Lina Huang, Dilip Sharma, Xiaozhou Feng, Zhiqiang Pan, Shaogen Wu, Daisy Munoz, Alex Bekker, Huijuan Hu, Yuan-Xiang Tao
Summary: The study found that RALY, an RNA-binding protein, plays a role in nerve trauma-induced nociceptive hypersensitivity by regulating the expression of translation initiation factor Eif4g2 in dorsal root ganglion neurons. Interventions targeting RALY expression levels could alleviate the development and maintenance of pain hypersensitivity.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Cell Biology
Risa Domoto, Fumiko Sekiguchi, Maho Tsubota, Atsufumi Kawabata
Summary: Neuroimmune crosstalk plays a crucial role in both somatic and visceral pathological pain, with macrophages interacting with neurons to regulate pain signals in peripheral tissues; recent studies have uncovered different characteristics and mediators of macrophages from various sources, highlighting their multitasking abilities in homeostatic conditions.
Article
Neurosciences
Yuying Huang, Hong Chen, Daozhong Jin, Shao-Rui Chen, Hui -Lin Pan
Summary: The spinal dorsal horn contains excitatory neurons expressing vesicular glutamate transporter-2 (VGluT2) and inhibitory neurons expressing vesicular GABA transporter (VGAT), which have different roles in nociceptive transmission. The study shows that presynaptic NMDARs amplify primary afferent input in neuropathic pain, while postsynaptic NMDARs play a dominant role in chronic pain caused by traumatic nerve injury. This reveals the divergent synaptic connectivity and functional significance of presynaptic and postsynaptic NMDARs in regulating cell type-specific nociceptive input in neuropathic pain with different etiologies.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Anesthesiology
Yan-Yan Wu, Qian Wang, Ping-An Zhang, Cheng Zhu, Guang-Yin Xu
Summary: There is mounting evidence that microRNAs (miRNAs) have critical roles in various pathophysiological conditions and diseases. However, the physiological impact of extracellular miRNAs on disease-related ion channels is largely unknown. In this study, miR-1306-3p was found to stimulate action potentials and inward currents in rat dorsal root ganglion (DRG) neurons. These effects were inhibited by the P2X3 receptor inhibitor A317491 or after knocking down P2X3Rs in DRG neurons. Specific interaction sites on the extracellular domain of P2X3Rs were identified as the miR-1306-3p binding sites. Intrathecal injection of miR-1306-3p induced visceral pain in rats while intrathecal application of a miR-1306-3p inhibitor and A317491 alleviated chronic visceral pain in a rat model.
Article
Neurosciences
Jianxiong Wei, Shuyang Chang, Siyi Liu, Lixia Tian, Xuan Zhu, Shuo Wang, Xiaoqiong Zhou, Yuying Wang, Linping Xu, Fu-Quan Huo, Lingli Liang
Summary: In this study, researchers investigated the role of LSD1, a histone demethylase and transcriptional co-repressor, in radicular pain. They found that LSD1 was upregulated in compressed and injured nerve ganglia, suggesting it may contribute to pain hypersensitivities. These findings suggest that LSD1 could serve as a potential target for the treatment of radicular pain and neuropathic pain.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Guang-Fen Zhang, Shao-Rui Chen, Daozhong Jin, Yuying Huang, Hong Chen, Hui-Lin Pan
Summary: Systemic treatment with resiniferatoxin (RTX) induces small-fiber sensory neuropathy by damaging TRPV1-expressing primary sensory neurons and leads to distinct thermal sensory impairments and tactile allodynia. The synaptic plasticity associated with RTX-induced tactile allodynia involves alpha 2 delta-1 upregulation in the dorsal root ganglion (DRG) and increased physical interaction between alpha 2 delta-1 and GluN1 in spinal cord synaptosomes, leading to potentiation of nociceptive input and tactile allodynia.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Orthopedics
D. Chao, H. Tran, Q. H. Hogan, B. Pan
Summary: GFS produces analgesia in MIA-OA rats at least in part by producing blockade of afferent inputs, possibly also by blocking efferent activity from the dorsal horn.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Neurosciences
Kelsey G. Guenther, Zhili Xu, Julian Romero, Cecilia J. Hillard, Ken Mackie, Andrea G. Hohmann
Summary: CB2 agonists can suppress pathological pain in animal models without unwanted side effects associated with CB1 receptor activation. However, the specific types of pain responsive to CB2 agonists and the cell types underlying therapeutic efficacy are not fully understood.
Article
Plant Sciences
Dandan Yue, Zihan Zheng, Weiwei Fan, Lizhong Zhu, Dan Lin, Man Lu, Wenjing Ji, Peng Cao, Xiaoyan Sun, Chunping Hu
Summary: SXS may have an effect on inhibiting ectopic tissue growth, enhancing pain thresholds, reducing nerve fiber density and inflammatory factor expression, and alleviating inflammatory cell infiltration in the dorsal root ganglion of animals with endometriosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Neurosciences
Long He, Jing Cao, Bao-Chun Jiang, Jian-Jun Yang, Yuan-Xiang Tao, Yanqiu Ai
Summary: In this study, it was found that spinal nerve ligation upregulated CCAAT/enhancer-binding protein-beta (C/EBP beta) expression in injured dorsal root ganglion, leading to the upregulation of toll-like receptor 7 (TLR7). The activation of TLR7 was associated with cold/thermal hyperalgesia and mechanical allodynia. Mechanistically, an increased binding of C/EBP beta to T1r7 promoter was observed. These findings highlight the importance of C/EBP beta in nerve trauma-induced TLR7 upregulation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Wen Chen, Xiaotong Wang, Qingyu Sun, Yurui Zhang, Jing Liu, Tingting Hu, Weihua Wu, Chao Wei, Meng Liu, Yumeng Ding, Dianxin Liu, Yingzi Chong, Peipei Wang, Hongwei Zhu, Weihua Cui, Jiannan Zhang, Qian Li, Fei Yang
Summary: The NLRP3 pathway is activated in the DRG of the DNP model, and TET2 is involved in DNP hypersensitivity by upregulating the TXNIP/NLRP3 pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Pharmacology & Pharmacy
Wen-Long Qiao, Qing Li, Jia-Wei Hao, Shuang Wei, Xue-Mei Li, Ting-Ting Liu, Chun-Yu Qiu, Wang-Ping Hu
Summary: This study found a functional interaction between LPA and P2X3 receptors in rat sensory neurons. LPA enhanced the activity of P2X3 receptors through activation of the LPA(1) receptor and PKC pathway, exacerbating nociceptive behaviors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Juping Xing, Hongji Wang, Lisha Chen, Hanxi Wang, Huan Huang, Jiabao Huang, Changshui Xu
Summary: This study investigated the role of Cx43 in neuropathic pain mediated by the P2X4 receptor in rats with chronic constriction injury (CCI). The results showed that blocking Cx43 can alleviate neuropathic pain in CCI rats through the P2X4, p38, ERK, and NF-kB signaling pathways. These findings suggest that Cx43 may be a promising therapeutic target for the development of novel pharmacological agents in the management of neuropathic pain.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jeffrey R. McArthur, Nehan R. Munasinghe, Rocio K. Finol-Urdaneta, David J. Adams, Macdonald J. Christie
Summary: Research has shown that Pn3a produces analgesic effects by inhibiting HVA Ca(v), with enhanced inhibition observed when co-administered with opioid agonists.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anesthesiology
Jason Ivanusic, Yasutaka Konishi, Michael J. Barrington
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2018)
Article
Multidisciplinary Sciences
Abdullah Jawad Alshawaf, Serena Viventi, Wanzhi Qiu, Giovanna D'Abaco, Bryony Nayagam, Michael Erlichster, Gursharan Chana, Ian Everall, Jason Ivanusic, Efstratios Skafidas, Mirella Dottori
SCIENTIFIC REPORTS
(2018)
Article
Education, Scientific Disciplines
Kylie Pickles, Jason J. Ivanusic, Junhua Xiao, Callum Durward, Andrea B. Ryan, Jennifer A. Hayes
ANATOMICAL SCIENCES EDUCATION
(2019)
Article
Anesthesiology
Sara Nencini, Jenny Thai, Jason J. Ivanusic
EUROPEAN JOURNAL OF PAIN
(2019)
Article
Endocrinology & Metabolism
Michael Morgan, Sara Nencini, Jenny Thai, Jason J. Ivanusic
Letter
Anesthesiology
Jason Ivanusic, Yasutaka Konishi, Michael J. Barrington
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2019)
Article
Cell Biology
Jenny Thai, Alanna C. Green, Lincon A. Stamp, Nick J. Spencer, Louise E. Purton, Jason Ivanusic
CELL AND TISSUE RESEARCH
(2019)
Review
Endocrinology & Metabolism
Jennifer M. Brazill, Alec T. Beeve, Clarissa S. Craft, Jason J. Ivanusic, Erica L. Scheller
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Neurosciences
Jenny Thai, Melinda Kyloh, Lee Travis, Nick J. Spencer, Jason J. Ivanusic
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Neurosciences
Zuoheng Qin, David G. Gonsalvez, Rhiannon J. Wood, Fatemeh Daemi, Sangwon Yoo, Jason J. Ivanusic, Elizabeth J. Coulson, Simon S. Murray, Junhua Xiao
JOURNAL OF NEUROSCIENCE RESEARCH
(2020)
Article
Cell & Tissue Engineering
Serena Viventi, Stefano Frausin, Sara E. Howden, Shiang Y. Lim, Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, Kwaku Dad Abu-Bonsrah, Wayne Ng, Jason Ivanusic, Lachlan Thompson, Mirella Dottori
Summary: Friedreich ataxia is characterized by degeneration of sensory neurons due to low Frataxin levels. Transplantation of stem cell-derived progenitors into DRG regions showed survival and differentiation, expressing neuronal markers. This study suggests the potential of using stem cells for cell replacement therapy in treating neurodegeneration in FRDA.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Anesthesiology
Michael Morgan, Jenny Thai, Vida Nazemian, Richard Song, Jason J. Ivanusic
Summary: This study explored the role of innervation of knee joint articular tissues and surrounding bone in osteoarthritis (OA) pain. The findings suggest that early OA pain is driven by nerves that innervate the joint capsule, while late OA pain involves the recruitment of nerves that innervate the subchondral bone. These results highlight the importance of targeting bone innervation for the development of mechanism-based therapies for late OA pain.
Article
Neurosciences
Michael Morgan, Jenny Thai, Phu Trinh, Mohamed Habib, Kelly N. Effendi, Jason J. Ivanusic
Meeting Abstract
Anatomy & Morphology
Andrea Burke Ryan, Callum Durward, Jenny Hayes, Jason Ivanusic, Kylie Pickles, Junhua Xiao
JOURNAL OF ANATOMY
(2020)
Article
Ophthalmology
Abdulhakeem S. Alamri, James A. Brock, Chandana B. Herath, Indu G. Rajapaksha, Peter W. Angus, Jason J. Ivanusic
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)