Article
Engineering, Biomedical
Alejandro Luis Callara, Alberto Greco, Johannes Frasnelli, Gianluca Rho, Nicola Vanello, Enzo Pasquale Scilingo
Summary: The study identified the brain network involved in olfactory perception and evaluation of odor valence, highlighting the central role of OFC in processing pleasant and unpleasant stimuli. Different brain regions, including CgG, STG, PCC/PCu, and PHG, were also found to play a role in the emotion recognition/categorization and memory processes related to odor perception. Bidirectional interactions between these regions and OFC were observed, suggesting a dynamic change in the hedonic olfactory network based on odor valence.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Biology
Shivathmihai Nagappan, Kevin M. Franks
Summary: The study found that semilunar (SL) and superficial pyramidal (PYR) neurons play different roles in odor processing in the olfactory cortex, with SLs receiving and integrating olfactory bulb input, and PYRs transforming and transmitting this input.
Article
Biology
Norimitsu Suzuki, Malinda L. S. Tantirigama, K. Phyu Aung, Helena H. Y. Huang, John M. Bekkers
Summary: Excitation triggered by odors in the primary olfactory cortex activates two types of interneurons - neurogliaform (NG) cells and horizontal (HZ) cells - which provide feedforward inhibition. NG cells fire earlier than HZ cells due to a faster excitatory synaptic drive, leading to strong but transient inhibition in layer 2 principal cells, while HZ cells offer more diffuse and lasting feedforward inhibition. These findings highlight the intricate operations of inhibition in the piriform cortex.
Article
Neurosciences
Marco de Curtis, Laura Librizzi, Laura Uva
Summary: Seizures affecting the limbic regions, such as the hippocampus, are common and often resistant to medication. This study examines the network mechanisms involved in the generation of olfactory-limbic epileptiform patterns and discusses the potential relevance of these findings for human focal epilepsy. The interactions within olfactory-limbic circuits, including region-specific seizure-like events and cortical control, are investigated using in vitro preparations and pro-convulsive drugs.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Yuka Donoshita, Uk-Su Choi, Hiroshi Ban, Ikuhiro Kida
Summary: Olfaction could be an early marker of neurodegenerative diseases. This study used 7-Tesla fMRI to assess olfactory function in the human brain and found that the piriform cortex is mainly associated with subjective odor intensity, while the posterior orbitofrontal cortex is involved in discriminating the subjective hedonic tone of the odorant.
Article
Neurosciences
Gozde Filiz, Daphnee Poupon, Sarah Banks, Pauline Fernandez, Johannes Frasnelli
Summary: Brain plasticity is crucial for experts to acquire necessary abilities. In this study, a longitudinal design was used to investigate the brain plasticity of sommelier students. It was found that the volume of the olfactory bulb increased in sommelier students, while there were no significant changes in cortical thickness and olfactory performance. This is the first longitudinal study to report the effects of training-related brain plasticity on the olfactory bulb volume in olfaction experts.
HUMAN BRAIN MAPPING
(2022)
Article
Psychology, Multidisciplinary
Mira Schwarz, Kai Hamburger
Summary: Despite the focus on visual perception, recent research has shown that humans can use their sense of smell for orientation, especially when processed implicitly.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Cell Biology
Shoko Nakamuta, Masanori Mori, Miho Ito, Masanori Kurita, Masao Miyazaki, Yoshio Yamamoto, Nobuaki Nakamuta
Summary: The olfactory organ of turtles has an upper chamber epithelium (UCE) with associated glands and a lower chamber epithelium (LCE) devoid of glands. The UCE is responsible for detecting airborne odorants, while the LCE detects waterborne odorants. This study investigated the localization of odorant receptors (ORs) in green sea turtle hatchlings, finding that class I ORs were mainly expressed in the LCE, suggesting its sensitivity to waterborne odorants, whereas class II ORs were expressed in both the UCE and LCE, indicating that the entire olfactory organ detects airborne odorants. The widespread expression of class II ORs may enhance sea turtles' ability to sense airborne odorants.
CELL AND TISSUE RESEARCH
(2023)
Article
Neurosciences
Johanna K. K. Kostka, Ileana L. L. Hanganu-Opatz
Summary: Cognitive processing in neonatal mice relies on the functional refinement of the limbic circuitry, with early olfactory processing playing a crucial role in shaping activity within these circuits. Through in vivo recordings and manipulations of mitral/tufted cells in the olfactory bulb, researchers found that the neonatal olfactory bulb synchronizes the limbic circuitry and drives activity in the lateral entorhinal cortex, hippocampus, and prefrontal cortex. This suggests that the olfactory bulb plays a significant role in the communication within limbic circuits during neonatal development.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Neurosciences
Chelsea Hook, Adam. C. C. Puche
Summary: The circuit operations of the olfactory bulb are modulated by higher order projections from multiple regions, including glutamatergic and GABAergic projections. The GABAergic neurons in the bulb show remarkable specificity in targeting other primary olfactory cortical regions, suggesting their role in modulating synaptic processing and associational processing of olfactory information.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Neurosciences
Ivan Ninenko, Daria F. Kleeva, Nikita Bukreev, Mikhail A. Lebedev
Summary: Electroencephalography (EEG) correlates of olfaction have both fundamental and practical importance. Olfactory-based brain-computer interfaces (BCIs) have the potential to aid in neurorehabilitation for olfactory disorders. However, previous EEG investigations in the olfactory domain have yielded inconsistent results. In this study, we developed an experimental paradigm to analyze the neural processing of olfactory stimuli using EEG recordings during an instructed-delay task. Our findings suggest that EEG recordings can effectively detect active processing of odors, making them suitable for integration in olfactory BCIs.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Psychology, Multidisciplinary
Vasudeva Murthy Challakere Ramaswamy, Tony Butler, Bianca Ton, Kay Wilhelm, Philip B. Mitchell, Lee Knight, David Greenberg, Andrew Ellis, Val Gebski, Peter William Schofield
Summary: This study examined the relationship between olfactory deficits and traumatic brain injury in impulsive violent offenders. The results showed that olfactory identification ability was associated with age, cognitive ability, impulsivity, TBI severity, social connectedness, childhood sexual abuse, suicidality, and heroin use. These findings suggest that olfactory testing may have utility in further studies of offenders.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Otorhinolaryngology
Anna Oleszkiewicz, Laura Bottesi, Michal Pieniak, Shuji Fujita, Nadejda Krasteva, Gabriele Nelles, Thomas Hummel
Summary: This study found that performing OT twice a day was more effective in supporting olfactory rehabilitation and interventions targeted to verbal semantic fluency, especially in subjects with lower baseline scores.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Geriatrics & Gerontology
Cynthia Felix, Lana M. Chahine, James Hengenius, Honglei Chen, Andrea L. Rosso, Xiaonan Zhu, Zichun Cao, Caterina Rosano
Summary: This study compared the gray matter microstructural characteristics of olfactory regions in older adults with and without hyposmia. The results showed that older adults with higher mean diffusivity in regions important for olfaction are more likely to have hyposmia up to ten years prior. The findings suggest that hyposmia could potentially serve as an early biomarker for brain microstructural abnormalities in older adults with varying cognitive functions.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychology, Biological
Jorge Rodrigues, Maria Ines Rocha, Francisco Teixeira, Beatriz Resende, Armando Cardoso, Susana Sa, Ricardo Pinto Vaz, Kristof Raemdonck
Summary: In this study, an animal model of allergic rhinitis was used to investigate the changes in the olfactory pathway and related areas. The results showed alterations in synaptic activity and structural changes in essential components of the olfactory pathway and prefrontal cortex.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Behavioral Sciences
William D. Klipec, Kristin R. Burrow, Casey O'Neill, Jun-li Cao, Chloe R. Lawyer, Eric Ostertag, Melissa Fowler, Ryan K. Bachtell, Kurt R. Illig, Donald C. Cooper
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Neurosciences
Rachel B. Kay, Elizabeth Amory Meyer, Kurt R. Illig, Peter C. Brunjes
JOURNAL OF COMPARATIVE NEUROLOGY
(2011)
Article
Multidisciplinary Sciences
Anna K. Garske, Chloe R. Lawyer, Brittni M. Peterson, Kurt R. Illig
Article
Neurosciences
K. R. Illig
Article
Neurosciences
Elizabeth Amory Meyer, Kurt R. Illig, Peter C. Brunjes
JOURNAL OF COMPARATIVE NEUROLOGY
(2006)
Review
Neurosciences
PC Brunjes, KR Illig, EA Meyer
BRAIN RESEARCH REVIEWS
(2005)
Article
Neurosciences
KR Illig
JOURNAL OF COMPARATIVE NEUROLOGY
(2005)
Article
Neurosciences
JM Mirich, KR Illig, PC Brunjes
JOURNAL OF COMPARATIVE NEUROLOGY
(2004)
Article
Neurosciences
KR Illig, LB Haberly
JOURNAL OF COMPARATIVE NEUROLOGY
(2003)
Article
Neurosciences
JJ Ekstrand, ME Domroese, SL Feig, KR Illig, LB Haberly
JOURNAL OF COMPARATIVE NEUROLOGY
(2001)
Article
Neurosciences
KR Illig, YP Danilov, A Ahmad, CBY Kim, PD Spear
Article
Neurosciences
DMG Johnson, KR Illig, M Behan, LB Haberly
JOURNAL OF NEUROSCIENCE
(2000)