期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 510, 期 5, 页码 525-538出版社
WILEY
DOI: 10.1002/cne.21798
关键词
photoreceptors; horizontal cells; bipolar cells; amacrine cells; visual acuity
资金
- Canadian Institutes of Health [151145]
- Alberta Heritage Foundation for Medical Research equipment
- Canadian National Institute for the Blind
- Lena McLaughlin Foundation (Mona Rod McLennan)
- INSERM/CIHR
- Foundation Fighting Blindness Canada
- NSERC Canada Graduate Scholarship
- AHFMR post-doctoral fellowship
- Barbara Tuck/MacPhee Family Vision Research Award in Macular Degeneration
Unlike laboratory rats and mice, muridae of the Arvicanthis family (A. ansorgei and A. niloticus) are adapted to functioning best in daylight. To date, they have been used as experimental models mainly in studies of circadian rhythms. However, recent work aimed at optimizing photoreceptor-directed gene delivery vectors (Khani et a]. 12007] Invest Ophthalmol Vis Sci 48:3954-3961) suggests their potential usefulness for studying retinal pathologies and therapies. In the present study we analyzed the retinal anatomy and visual performance of the Nile grass rat (A. niloticus) using immunohistofluorescence and the optokinetic response (OKR). We found that approximate to 35-40% of photoreceptors are cones; that many neural features of the inner retina are similar to those in other diurnal mammals; and that spatial acuity, measured by the OKR, is more than two times that of the usual laboratory rodents. These observations are consistent with the known diurnal habits of this animal, and further support its pertinence as a complementary model for Studies of structure, function, and pathology in cone-rich mammalian retinae.
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