期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 511, 期 5, 页码 581-598出版社
WILEY
DOI: 10.1002/cne.21851
关键词
epilepsy; astroglia; gliogenesis; hippocampus; entorhinal cortex; hyperexcitability; AEDs; alpha-aminoadipic acid
资金
- Korea Science & Engineering Foundation [R01-2005-000-10004-0, M103KV010019-03K2201-01910]
- Korea Research Foundation [KRF-2005-015-E00003]
- National Research Foundation of Korea [2005-015-E00003, R01-2005-000-10004-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Recently we reported that astroglial loss and subsequent gliogenesis in the dentate gyrus play a role in epileptogenesis following pilocarpine-induced status epilepticus (SE). In the present study we investigated whether astroglial damages in the hippocampo-entorhinal complex following SE are relevant to pathological or electrophysiological properties of temporal lobe epilepsy. Astroglial loss/damage was observed in the entorhinal cortex and the CA1 region at 4 weeks and 8 weeks after SE, respectively. These astroglial responses in the hippocampo-entorhinal cortex were accompanied by hyperexcitability of the CA1 region (impairment of paired-pulse inhibition and increase in excitability ratio). Unlike the dentate gyrus and the entorhinal cortex, CA1 astroglial damage was protected by conventional anti-epileptic drugs. a-Aminoadipic acid (a specific astroglial toxin) infusion into the entorhinal cortex induced astroglial damage and changed the electrophysiological properties in the CA1 region. Astroglial regeneration in the dentate gyrus and the stratum oriens of the CA1 region was found to originate from gliogenesis, while that in the entorhinal cortex and stratum radiatum of the CA1 region originated from in situ proliferation. These findings suggest that regional specific astroglial death/regeneration patterns may play an important role in the pathogenesis of temporal lobe epilepsy. J. Comp. Neurol. 511:581-598, 2008. (C) 2008 Wiley-Liss, Inc.
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