期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 12, 期 1, 页码 20-24出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc900143h
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资金
- CSIR, New Delhi
Libraries of henzoxanthenes, as well as of benzochromenes, were efficiently synthesized via one-pot, three-component reactions of 2-naphthol, aldehydes, and cyclic 1,3-diketones/malononitrile/ethyl cyanoacetate in the presence of catalytic amount of ceric ammonium nitrate (CAN) under solvent free conditions. The protocol offers rapid synthesis of structurally diverse benzoxanthenes and benzochromenes for biologically screening. All the synthesized compounds were evaluated for their anti-proliferative activity, and several Compounds were exhibiting promising anti-proliferative activity.
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