期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 12, 期 6, 页码 836-843出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc100091h
关键词
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资金
- National Institutes of Health [AI577045, AI 070791]
The 1-oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) protease. Exploratory studies have led to the identification of a WNV protease inhibitor (a 1-oxo-1, 2-dihydroisoquinoline-based derivative, 12j) which could potentially serve as a launching pad for a hit-to-lead optimization campaign. The identified hit was devoid of any inhibitory activity toward a panel of mammalian serine proteases.
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