☆ 3.8 Article

Multiplicity of Diverse Heterocycles from Polymer-Supported α-Acylamino Ketones

JOURNAL OF COMBINATORIAL CHEMISTRY (2009)

期刊

JOURNAL OF COMBINATORIAL CHEMISTRY

卷 11, 期 5, 页码 851-859

出版社

AMER CHEMICAL SOC

DOI: 10.1021/cc9000532

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Chemistry, Applied Chemistry, Medicinal Chemistry, Multidisciplinary

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Department of Chemistry and Biochemistry at the University of Notre Dame
NIH [GM079576]

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Polymer-supported alpha-acylamino ketones were transformed to seven types of structurally unrelated heterocyclic compounds. Syntheses involved variety of chemical routes and comprised diverse chemistries (C-C, C=C, C-N, C=N, and C-O bond formations), Different sizes of heterocycles (4-, 5-, 6-, and 7-membered rings.) were prepared, including dihydro-pyrrol-2-ones, pyrazin-2-ones, dihydro-triazepin-6-ones, morpholin-3-ones, imidazoles, beta-lactams, and isoquinolin-1-ones. Further elaboration to fused ring systems was also documented.

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