期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 357, 期 1, 页码 70-74出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2011.01.089
关键词
Magnetoliposome; Magnetic nanoparticle; Electromagnetic heating; Hyperthermia; Lipid bilayer
资金
- National Science Foundation [CBET-0931875]
- NASA
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0931875] Funding Source: National Science Foundation
Temperature measurements have been made within magnetite (Fe3O4) nanoparticle-liposome dispersions subjected to electromagnetic field at radiofrequency (RF) heating based on the fluorescence anisotropy of diphenylhexatriene (DPH) embedded within the bilayer. Incorporating cholesterol within dipalmitoylphosphatidylcholine (DPPC) bilayers broadened the anisotropy window associated with lipid melting. Cryogenic transmission electron microscopy showed that the dispersions contained magnetoliposomes with nanoparticle aggregates at both low and high encapsulation densities. RF heating results demonstrated the ability to measure the temperature of the ML bilayer with on/off RF cycles using DPH anisotropy. These measurements reflected the temperature of the bulk aqueous phase, which is consistent with previous work showing rapid heat dissipation from a nanoparticle surface during RF heating and a negligible difference between surface and bulk temperature. (C) 2011 Elsevier Inc. All rights reserved.
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