期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 361, 期 1, 页码 33-41出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2011.05.023
关键词
Gemini imidazolium amphiphile; Gemini pyridinium amphiphile; cmc; DNA interaction; Cytotoxicity
资金
- CSIR (Council of Scientific & Industrial Research) New Delhi, India [01(2077)106/EMR-II]
- DST-INSPIRE
Two series of phenoxy ring containing long chain imidazolium and pyridinium based gemini amphiphiles have been synthesized from renewable cardanol oil having different spacers (i. e. -S-(CH2)(n)-S-, where n is 2, 3, 4 & 6). Critical micelle concentration (cmc) of these new gemini amphiphiles has been determined by conductivity method. Further, these new cationic amphiphiles have been evaluated for their DNA binding capability by agarose gel electrophoresis, ethidium bromide exclusion experiments and transmission electron microscopy (TEM). The cytotoxicity of these new amphiphiles have been evaluated by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. Comparative studies of these phenoxy ring containing long chain gemini imidazolium amphiphiles and their pyridinium analogues depicted low cmc values of the later but greater DNA interaction capability and low cytotoxicity of the former series of amphiphiles. (C) 2011 Elsevier Inc. All rights reserved.
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