期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 352, 期 2, 页码 405-414出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2010.09.014
关键词
Thermosensitive; Y shaped polymer; Polymeric micelles; Self assembly
资金
- National Natural Science Foundation of China (NSFC) [20804003]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars
- State Education Ministry
- Chinese Universities Scientific Fund
One novel type of Y shaped amphiphilic copolymers with two hydrophobic poly(solketal acrylate) (PSA) branches and one hydrophilic monomethoxy poly(ethylene glycol) (MPEG) block was synthesized by atom transfer radical polymerization (ATRP) These Y-shaped polymers can disperse in aqueous media to self-assemble into micellar aggregates with a spherical core-shell structure The aqueous copolymer solutions exhibited transmittancy transition in the temperature range of 30-60 degrees C via optical transmittance measurements An Interesting thermo-dependent size of the micellar aggregates was observed by dynamic light scattering techniques and transmission electron microscopy which showed that the micelle diameters were decreased with temperature increasing The nile red release from the micelles at 25 degrees C and 37 degrees C under various pHs showed that temperature has great influence on release behavior With good biocompatibility the micellar aggregates formed from MPEG-block-(PSA)(2) may serve as one promising thermosensitive nanovehicle for targeted drug delivery (C) 2010 Elsevier Inc All rights reserved
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