期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 345, 期 2, 页码 269-277出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2010.02.012
关键词
Emulsion sol-gel method; Porous silica nanosphere; Ibuprofen; In situ encapsulation; Release behavior
资金
- National Natural Science Foundation of China [10776034, 20871118]
- Chinese Academy of Sciences (CAS) [KGCX2-YW-111-5]
In this work, in situ encapsulation of ibuprofen (IBU) was explored preliminarily using the emulsion sol-gel method. IBU-containing porous silica nanospheres (300-400 nm) of varied morphologies were fabricated simply by tailoring the amount of IOU in the starting solution. In the reaction system, IBU exists in the form of IBU- under basic conditions, which has strong electrostatic interaction with CTA(+), and thus could be regarded as cosurfactant to regulate the morphology and structure of silica nanospheres. Such morphology can be maintained even after calcination or IBU release in phosphate-buffered saline. The current results may shed light on the design and construction of new functional nanoarchitectures, which may be useful for drug delivery, separation, adsorption, catalysis, etc. (c) 2010 Elsevier Inc. All rights reserved.
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