Article
Oncology
Frank J. Jenkins, Tsion Z. Minas, Wei Tang, Tiffany H. Dorsey, Stefan Ambs
Summary: This study found that HHV-8 infection is associated with an increased risk of prostate cancer in men harboring the IFNL4-Delta G variant, supporting the hypothesis that IFNL4-Delta G is a susceptibility factor for prostate cancer.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Virology
Kamil Grubczak, Anna Grzeszczuk, Monika Groth, Anna Hryniewicz, Anna Kretowska-Grunwald, Robert Flisiak, Marcin Moniuszko
Summary: HIV/HCV coinfection increases the burden of HCV infection and accelerates disease progression, while regulatory T cells play a crucial role in antiviral immune response during viral treatment.
Article
Gastroenterology & Hepatology
Yuan-Ji Ma, Ling-Yao Du, Li-Bo Yan, Juan Liao, Xing Cheng, Wu-Wei Xie, Hong Tang
Summary: This study aimed to investigate the long-term prognosis of HCV-infected patients who underwent PR regimen and achieved SVR24. Results showed a low incidence of HCC and progression of liver disease, with cirrhotic patients facing a higher risk of poor prognosis. Recurrence of HCV was rare in responders with SVR24 who had corrected their risky behaviors.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Mustafa Kamal, Arsalan Jamil Raja, Tanveer Ahmed, Mashhood Ali, Faisal Rasheed
Summary: The study aimed to compare the efficacy of different treatments for HCV genotype 3a infected patients, and found that the combination therapy of Sofosbuvir plus Ribavirin with Pegylated Interferon-alpha had a higher eradication rate against HCV genotype 3a in the local setting of Pakistan.
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
(2021)
Article
Biology
Nikola S. Kokanov, Snezana P. Jovanovic-Cupic, Marina M. Siljic, Valentina S. Cirkovic, Nina M. Petrovic, Bojana R. Kozik, Milena M. Krajnovic
Summary: Amino acid substitutions in the HCV core region combined with IL28B genotypes and RASSF1A/p16 methylation may influence the response to PEG-IFN/RBV therapy in patients with genotype 1b chronic hepatitis C.
ARCHIVES OF BIOLOGICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Alessio Aghemo, Alfredo Alberti, Pietro Andreone, Mario Angelico, Maurizia Rossana Brunetto, Luchino Chessa, Alessia Ciancio, Antonio Craxi, Giovanni Battista Gaeta, Massimo Galli, Antonio Gasbarrini, Alessia Giorgini, Elisabetta Grilli, Pietro Lampertico, Miriam Lichtner, Michele Milella, Filomena Morisco, Marcello Persico, Mario Pirisi, Massimo Puoti, Giovanni Raimondo, Antonietta Romano, Maurizio Russello, Vincenzo Sangiovanni, Monica Schiavini, Gaetano Serviddio, Erica Villa, Maria Vinci, Antonella De Michina, Valentina Gallinaro, Giuliana Gualberti, Antonio Saverio Roscini, Anna Linda Zignego
Summary: The MARS post-marketing, observational study evaluated the use of glecaprevir/pibrentasvir in Italian patients infected with HCV. The study showed high SVR12 rates, good safety profiles, and improvements in quality of life.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Anesthesiology
Pier Francesco Caruso, Giovanni Angelotti, Massimiliano Greco, Marco Albini, Victor Savevski, Elena Azzolini, Martina Briani, Michele Ciccarelli, Alessio Aghemo, Hayato Kurihara, Antonio Voza, Salvatore Badalamenti, Michele Lagioia, Maurizio Cecconi
Summary: The study investigated the impact of COVID-19 on hospitals in Lombardy, Italy in February 2020 and proposed a new visual analysis technique using heat maps. By analyzing electronic health records, the study found that COVID-19 patients exhibited significant abnormalities in vital signs compared to non-COVID-19 patients.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Oncology
Ana Lleo, Francesca Colapietro, Patrick Maisonneuve, Monia Aloise, Vincenzo Craviotto, Roberto Ceriani, Lorenza Rimassa, Salvatore Badalamenti, Matteo Donadon, Vittorio Pedicini, Alessandro Repici, Luca Di Tommaso, Antonio Voza, Guido Torzilli, Alessio Aghemo
Summary: Jaundice is a common clinical presentation in cholangiocarcinoma patients, with factors such as age, disease stage, presence of jaundice at diagnosis, and absence of concomitant viral hepatitis being associated with better survival. A nomogram predicting short-term survival was developed to aid in tailored management for these patients.
Review
Medicine, General & Internal
Nicola Pugliese, Maria Corina Plaz Torres, Salvatore Petta, Luca Valenti, Edoardo G. Giannini, Alessio Aghemo
Summary: NAFLD is a growing epidemic with no approved pharmacological treatments, lifestyle modifications such as reduced caloric intake and Mediterranean diet are the standard approach. Mediterranean diet is recommended for its ease of adherence and beneficial metabolic effects, improving both steatosis and cardiovascular risk factors.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Gastroenterology & Hepatology
Andrea Marcellusi, Francesco Saverio Mennini, Murad Ruf, Claudio Galli, Alessio Aghemo, Maurizia R. Brunetto, Sergio Babudieri, Antonio Craxi, Massimo Andreoni, Loreta A. Kondili
Summary: By simulating a Markov disease progression model, we evaluated the cost effectiveness and sustainability of different algorithms for HCV active infection diagnosis in a high endemic country. The results showed that HCV-RNA reflex testing is the most cost-effective diagnostic option.
LIVER INTERNATIONAL
(2022)
Letter
Gastroenterology & Hepatology
Nicola Pugliese, Luca di Tommaso, Ana Lleo, Ludovico Alfarone, Elisabetta Mastrorocco, Maria Terrin, Roberto Ceriani, Francesca Colapietro, Luigi Terracciano, Alessio Aghemo
LIVER INTERNATIONAL
(2022)
Letter
Gastroenterology & Hepatology
Chiara Masetti, Francesca Colapietro, Antonio Voza, Alessio Aghemo
LIVER INTERNATIONAL
(2022)
Letter
Gastroenterology & Hepatology
Gianluca Franchellucci, Maria Terrin, Alessio Aghemo, Nicola Pugliese
LIVER INTERNATIONAL
(2022)
Letter
Gastroenterology & Hepatology
Masetti Chiara, Colapietro Francesca, Voza Antonio, Aghemo Alessio
LIVER INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Alessio Aghemo, Marcello Persico, Roberta D'Ambrosio, Massimo Andreoni, Erica Villa, Abhi Bhagat, Valentina Gallinaro, Giuliana Gualberti, Rocco Cosimo Damiano Merolla, Antonio Gasbarrini
Summary: A study conducted in Italy found that G/P treatment achieved a 100% cure rate in patients with hepatitis C, even in high-risk groups such as elderly patients and those with advanced liver disease.
Review
Gastroenterology & Hepatology
Nicola Pugliese, Ludovico Alfarone, Ivan Arcari, Silvia Giugliano, Tommaso Lorenzo Parigi, Maria Rescigno, Ana Lleo, Alessio Aghemo
Summary: Nonalcoholic fatty liver disease (NAFLD) is replacing viral hepatitis as the leading cause of chronic liver disease and hepatocellular carcinoma (HCC) in many Western countries. NAFLD-associated HCC usually affects older patients with multiple comorbidities, frequently develops in the absence of cirrhosis, and is often diagnosed later with worse chance of survival. The worse prognosis is also due to limited surveillance strategies and a lower efficacy of standard treatments.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Alessio Aghemo, Alejandro Forner, Luca Valenti
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Loreta A. Kondili, Massimo Andreoni, Alessio Aghemo, Claudio Maria Mastroianni, Rocco Merolla, Valentina Gallinaro, Gianpiero D'Offizi, Antonio Craxi
Summary: This study evaluated the long-term impact of delayed HCV elimination due to the COVID-19 pandemic in Italy, and emphasized the need for extensive and efficient HCV screening and cure to avoid adverse outcomes.
LIVER INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Ligen Yu, Mohd Khanapi Abd Ghani, Alessio Aghemo, Debmalya Barh, Matteo Bassetti, Fausto Catena, Gaetano Gallo, Ali Gholamrezanezhad, Mohammad Amjad Kamal, Amos Lal, Kamal Kant Sahu, Shailendra K. Saxena, Ugo Elmore, Farid Rahimi, Chiara Robba, Yuanlin Song, Zhengyuan Xia, Boxuan Yu
Summary: This study analyzed keywords and found that factors such as the immune system and nutrition are related to COVID-19. It proposed that the human immune system is a complex system that employs self-destruct and rebuild strategies to fight microbial infections. Microbial infections may be self-limiting and provide essential nutrition for the patient. The study also discussed possible strategies to mitigate COVID-19, including vaccination.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Gastroenterology & Hepatology
Edoardo Vespa, Nicola Pugliese, Francesca Colapietro, Alessio Aghemo
Summary: SARS-CoV-2, responsible for COVID-19, shows a wide clinical spectrum with respiratory tract involvement being predominant, but gastrointestinal manifestations are also present possibly due to abundant ACE2 expression in the digestive tract.
TECHNIQUES AND INNOVATIONS IN GASTROINTESTINAL ENDOSCOPY
(2021)
