期刊
JOURNAL OF CLINICAL VIROLOGY
卷 47, 期 4, 页码 376-378出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jcv.2010.01.013
关键词
HIV-1 super-infection; Elite controller; Virological progression
类别
Super- and co-infection with HIV-1 are generally associated with accelerated disease progression. We report on the outcome of super-infection in two HIV-1 infected individuals previously known as elite controllers. Both presented an acute retroviral syndrome following super-infection and showed an immuno-virological progression thereafter. Host genotyping failed to reveal any of the currently recognized protective factors associated with slow disease progression. This report indicates that elite controllers should be informed of the risk of super-infection, and illustrates the complexity of mounting broad anti-HIV immunity. (C) 2010 Elsevier B.V. All rights reserved.
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