Article
Immunology
Zhongqiu Teng, Na Zhao, Ruotong Ren, Xue Zhang, Zhenshan Du, Pengfei Wang, Tian Qin
Summary: We identified four cases of flea-borne spotted fever caused by Rickettsia felis in a retrospective survey of 182 patients with fever of unknown origin in China. The clinical signs and symptoms of these patients were similar to other rickettsial diseases, including fever, rash, and liver and kidney dysfunction. All four patients in the study developed pneumonia or lung lesions after R. felis infection. The cases of R. felis infection were sporadic in multiple provinces of China, highlighting the risk posed by this neglected infectious disease to public health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Farnoosh Sarkhani Moghaddam, Mostafa Ghaderi, Masoud Parsania, Sayed-Hamidtma Mozhgani, Reza Atjmand
Summary: Human cosavirus (HCosV) is a newly recognized virus with potential links to nonpolio flaccid paralysis and acute gastroenteritis in pediatric patients. In a study conducted in an Iranian hospital, HCosV genomic RNA was detected in 1.25% of 160 cerebrospinal fluid samples from pediatric patients presenting with meningitis and encephalitis. These findings suggest a possible association between HCosV and neurological diseases in Iranian pediatric patients.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Article
Virology
Deyu Huang, Zheng Wang, Fengjuan Zhang, Ting Wang, Guanyou Zhang, Lintao Sai
Summary: The study investigated the molecular and clinical epidemiological features of human astrovirus infections in children under 5 with acute gastroenteritis in Shandong province, China. Results showed that HAstV infections were detected in all age groups, with main symptoms including fever, abdominal pain, vomiting, and dehydration, and the most prevalent genotype was HAstV-1.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Shanshan Cong, Chao Wang, Tianli Wei, Zhiping Xie, Yiman Huang, Jingjing Tan, Aijun Chen, Fenlian Ma, Lishu Zheng
Summary: This study investigated the epidemiology and genotypic diversity of HMPV in hospitalized children with ARTIs in Beijing, China. It found that HMPV is an important cause of ARTIs in children under 5 years old, with the peak occurring in winter and spring and the A2b subtype being the most common. The study also showed a significant decrease in HMPV infection among hospitalized children with ARTIs during the COVID-19 pandemic.
INFECTION GENETICS AND EVOLUTION
(2022)
Article
Virology
Esmeralda Vizzi, Rixio Fernandez, Luis A. Angulo, Ruth Blanco, Carlos Perez
Summary: This study investigated the viral cause of diarrhoea in HIV-infected patients using molecular assays. The results suggest that HCoSV may be a potential opportunistic agent causing persistent infection and deterioration in clinical conditions in HIV-infected patients. Screening procedures and monitoring including such viruses could be helpful in clinical management.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Pediatrics
Valentina Dapra, Paola Montanari, Marco Rassu, Cristina Calvi, Ilaria Galliano, Massimiliano Bergallo
Summary: This study investigates the occurrence of HCoSV and SAFV in pediatric patients with acute gastroenteritis in Turin, Italy. SAFV was detected in one case, which was also positive for Adenovirus, while HCoSV was not detected in any of the samples.
MINERVA PEDIATRICS
(2023)
Review
Health Care Sciences & Services
Yan-Qun Sun, Tao Wang, Yuan-Yuan Zhang, Tian-Le Che, Fan-Fei Meng, Ai-Ying Teng, Mei-Chen Liu, Ting-Ting Li, Bao-Gui Jiang, Qiang Xu, Chen-Long Lv, Jin-Jin Chen, Nan Zhou, Simon Hay, Li-Qun Fang, Wei Liu
Summary: This review provides insights into the occurrence, distribution, and epidemiological characteristics of vector-borne pathogens in China. The study found a wide range of pathogen species, including viruses, bacteria, and parasites, with Rickettsiales bacteria being the most common. Analysis of clinical information revealed that flu-like illness was the predominant manifestation of VBP infections.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Pediatrics
Xifeng Tang, Ge Dai, Ting Wang, Huiming Sun, Wujun Jiang, Zhengrong Chen, Yongdong Yan
Summary: In this study, the clinical data of hospitalized children with lower respiratory tract infections caused by human bocavirus (HBoV) and human metapneumovirus (hMPV) were compared. The detection rate of HBoV was significantly higher than that of hMPV. Compared to hMPV, HBoV is more likely to cause severe infection and has a greater impact on children.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Yi Chen, Tao Lin, Chang-Bing Wang, Wan-Li Liang, Guang-Wan Lian, Mark Zanin, Sook-San Wong, Xin-Gui Tian, Jia-Yu Zhong, Ying-Ying Zhang, Jia-Hui Xie, Ling-Ling Zheng, Fei-Yan Chen, Run Dang, Ming-Qi Zhao, Yi-Yu Yang, Rong Zhou, Bing Zhu
Summary: This study describes the epidemiology and subtype shifting of human adenovirus (HAdV) infection among children with acute respiratory illness in Guangzhou, China. The results showed a clear seasonal distribution of HAdV, with increased cases and a shift in dominant subtype from HAdV-3 to HAdV-7 in 2018 and 2019. The study also found an increase in mortality rate among children with severe HAdV cases.
WORLD JOURNAL OF PEDIATRICS
(2022)
Letter
Medicine, General & Internal
Shamez N. N. Ladhani, Gayatri Amirthalingam, Asma Khalil, Dan-Yu Lin
Summary: This study examines the hospitalization protection against the B.1.1.529 (omicron) variant of SARS-CoV-2 in children aged 5 to 11 who received the BNT162b2 vaccine and had previous infection. The study includes a small number of hospitalized children and wide confidence intervals. Four weeks after the first dose, vaccine effectiveness against omicron infection was similar between children with and without previous infection, but decreased over time.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Mohammad Hossein Razizadeh, Alireza Khatami, Mohammad Zarei
Summary: This meta-analysis examined the prevalence and association of Bufavirus (BuV), Human Cosavirus (HCoSV), and Saffold (SAFV) viruses with gastroenteritis (GE). The study found a low global prevalence for these viruses and no significant association with GE. BuV was more common in African GE patients, while SAFV was more common in Europe. BuV1 and BuV2 had similar prevalence among the identified genotypes. HCoSV-C was the most prevalent genotype of HCoSV, and SAFV2 was the most common genotype of SAFV. All of these viruses were more prevalent in children older than 5 years of age.
FRONTIERS IN MEDICINE
(2022)
Article
Virology
Yulian Fang, Yanzhi Zhang, Hong Wang, Ouyan Shi, Wei Wang, Mengzhu Hou, Lu Wang, Jinying Wu, Yu Zhao
Summary: Norovirus (NoV) is the leading cause of acute gastroenteritis worldwide, with GII.4 and GII.3 genotypes being predominant in children in Tianjin, China. The winter season sees a peak in NoV cases, with symptoms including diarrhea, vomiting, and dehydration.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Yiman Huang, Chao Wang, Fenlian Ma, Qiong Guo, Lihong Yao, Aijun Chen, Xiaoyi Luo, Lishu Zheng
Summary: The study described the epidemiology and genotypic diversity of HAdV in hospitalized children with RTIs in Beijing, China. The main epidemic strains were found to be HAdV-B3 and HAdV-B7, with a recombinant HAdV-C strain CBJ113 forming an epidemic trend.
Article
Medicine, General & Internal
Shu-Yu Lai, Yan-Ling Liu, Yong-Mei Jiang, Ting Liu
Summary: Acute respiratory tract infections pose a serious threat to children's health worldwide, with viral infections being the main cause. Public health measures implemented during the COVID-19 pandemic may effectively prevent the transmission of other respiratory viruses in children.
Review
Infectious Diseases
Julie Nguyen, Kallirroi Kotilea, Patrick Bontems, Veronique Yvette Miendje Deyi
Summary: In the context of epidemiology, the manifestation of Helicobacter pylori (H. pylori) infection varies between children and adults. The prevalence of H. pylori infection is decreasing globally, including in many developing countries. However, pediatric H. pylori infection and its consequences remain a concern in some areas. Most infected children do not show symptoms, and there is no evidence supporting the link between H. pylori and functional disorders like recurrent abdominal pain. The pathophysiology of H. pylori infection depends on complex bacterial virulence mechanisms and their interaction with the host immune system and environmental factors. Various gastritis phenotypes can develop, potentially leading to different gastroduodenal pathologies. The diagnosis of H. pylori infection in children requires upper gastrointestinal endoscopy with mucosal biopsy samples for histology and culture, or at least Polymerase Chain Reaction (PCR). Eradication treatment should be given when necessary and compliance is expected, with treatment choice based on antimicrobial susceptibility. Vigilant surveillance of resistance patterns and strategic antibiotic management are crucial for combating multidrug resistance.
Article
Biochemical Research Methods
Zena Cai, Yunshi Fan, Zheng Zhang, Congyu Lu, Zhaozhong Zhu, Taijiao Jiang, Tongling Shan, Yousong Peng
Summary: A systematic survey identified numerous viral circRNAs from 23 viral species, including both double-stranded DNA viruses and single-stranded RNA viruses. These viral circRNAs exhibit diverse characteristics and are involved in various cellular activities and diseases.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Virology
Shixing Yang, Tongling Shan, Yuqing Xiao, Heteng Zhang, Xiaochun Wang, Quan Shen, Yan Wang, Yuxin Yao, Qi Liu, Hao Wang, Wen Zhang
Summary: Analysis of pangolin metagenomic data suggests that pangolins may be intermediate hosts for SARS-CoV-2, but further sampling and analysis from various countries are needed for confirmation.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Microbiology
Chuanfeng Li, Tongling Shan, Zongyan Chen, Jiewen Zhou, Hang Li, Guangzhi Tong, Guangqing Liu
Summary: In 2015, a novel duck picornavirus, named duck/AH15/CHN/2015, was isolated from Cherry Valley ducks in Anhui province of China. It shares approximately 43% amino acid sequence identity with duck hepatitis A viruses (DHAV). The virus possesses a typical picornavirus-like genomic organization and is proposed to be a member of a novel species in the genus Avihepatovirus of the family Picornaviridae.
VETERINARY MICROBIOLOGY
(2021)
Article
Microbiology
Muddassar Hameed, Abdul Wahaab, Tongling Shan, Xin Wang, Sawar Khan, Di Di, Liu Xiqian, Jun-Jie Zhang, Muhammad Naveed Anwar, Mohsin Nawaz, Beibei Li, Ke Liu, Donghua Shao, Yafeng Qiu, Jianchao Wei, Zhiyong Ma
Summary: The study conducted metagenomic analysis of mosquito samples from animal farms in Yunnan province of China, revealing a highly diverse viral community with more than 19 viral taxonomic families. The viral reads included various animal viruses, suggesting a potential circulation of these viruses in vertebrate hosts. This study provides comprehensive knowledge of diverse viral populations in Yunnan province, which may pose a potential threat to both humans and domestic animals.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Cell Biology
Dage Sun, Ning Kong, Sujie Dong, Xiaoyong Chen, Wenzhen Qin, Hua Wang, Yajuan Jiao, Huanjie Zhai, Liwei Li, Fei Gao, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Wen Zhang, Guangzhi Tong, Tongling Shan
Summary: This study revealed the molecular mechanisms of selective autophagy in the host against viruses and demonstrated potential viral strategies to evade the autophagic process and IFN-I signaling for successful pathogenesis.
Article
Virology
Yu Zhang, Chunmei Wang, Ce Zhu, Wei Ye, Qin Gu, Chenbin Shu, Xiping Feng, Xi Chen, Wen Zhang, Tongling Shan
Summary: This study analyzed the expression profiles of circRNAs in gingival tissues of periodontitis patients with and without Redondoviridae infection, and identified key circRNAs associated with Redondoviridae-related periodontitis. Functional annotation and enrichment analysis revealed potential alterations in biological processes and metabolism in individuals suffering from Redondoviridae-infected periodontitis.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Genetics & Heredity
Xiaoyong Chen, Tongling Shan, Dage Sun, Huanjie Zhai, Sujie Dong, Ning Kong, Hao Zheng, Wu Tong, Guangzhi Tong
Summary: Porcine ZCCHC3 plays an inhibitory role in the proliferation of pseudorabies virus (PRV) by regulating cellular innate immune responses. Overexpression of ZCCHC3 inhibits viral titers and protein levels, while knockdown of ZCCHC3 promotes viral growth. ZCCHC3 overexpression upregulates IFN-beta expression to suppress viral replication. PRV infection reduces endogenous expression of ZCCHC3, and PRV-encoded UL13 and UL24 proteins inhibit ZCCHC3 expression, antagonizing its antiviral effect.
Article
Virology
Sujie Dong, Ning Kong, Yu Zhang, Youwen Li, Dage Sun, Wenzhen Qin, Huanjie Zhai, Xueying Zhai, Xinyu Yang, Chenqian Ye, Manqing Ye, Changlong Liu, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Wen Zhang, Guangzhi Tong, Tongling Shan
Summary: PEDV is a highly contagious swine virus that has caused significant economic damage to the global pork industry. Current vaccines are not fully effective, making it crucial to study the interaction between PEDV and its host. TARDBP effectively suppresses PEDV replication through proteasomal and autophagic degradation pathways, while also promoting the host's innate immune response by inducing IFN expression.
JOURNAL OF VIROLOGY
(2022)
Article
Environmental Sciences
Min Zhao, Chanjuan Yue, Zijun Yang, Yunli Li, Dongsheng Zhang, Ju Zhang, Shixing Yang, Quan Shen, Xiaoyan Su, Dunwu Qi, Rui Ma, Yuqing Xiao, Rong Hou, Xia Yan, Lin Li, Yanshan Zhou, Jiabin Liu, Xiaochun Wang, Wei Wu, Wen Zhang, Tongling Shan, Songrui Liu
Summary: The study found that feline panleukopenia virus (FPV) was prevalent in both giant pandas and red pandas, and other potentially pathogenic viruses were responsible for diseases or deaths in red pandas. The study also revealed instances of interspecies jumping events between giant pandas and their associated species. These findings are important for understanding the genetic diversity and viral transmission among giant pandas, associated animals, and arthropods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Virology
Eric Delwart, David Merriam, Amir Ardeshir, Eda Altan, Yanpeng Li, Xutao Deng, Dennis J. Hartigan-O'Connor
Summary: Idiopathic chronic diarrhea (ICD) is a common clinical problem in captive rhesus macaques, and viral metagenomics analysis revealed the presence of multiple viruses in the digestive tract tissues of animals with ICD. The distribution of viral reads varied between different gut tissues from the same animal, and in situ hybridization showed staining for both RNA and DNA viruses in the distal colon. The location of enteric viral nucleic acid differed widely between different viral families and along the length of the digestive tract.
Article
Microbiology
Tongling Shan, Shixing Yang, Haoning Wang, Hao Wang, Ju Zhang, Ga Gong, Yuqing Xiao, Jie Yang, Xiaolong Wang, Juan Lu, Min Zhao, Zijun Yang, Xiang Lu, Ziyuan Dai, Yumin He, Xu Chen, Rui Zhou, Yuxin Yao, Ning Kong, Jian Zeng, Kalim Ullah, Xiaochun Wang, Quan Shen, Xutao Deng, Jianmin Zhang, Eric Delwart, Guangzhi Tong, Wen Zhang
Summary: Using viral metagenomics, the virome of wild birds was investigated, revealing higher virus diversity compared to breeding birds. New virus families, genera, or species were identified, and potential cross-species transmission was observed.
Article
Virology
Fabiola Villanova, Flavio Augusto de Padua Milagres, Rafael Brustulin, Emerson Luiz Lima Araujo, Ramendra Pati Pandey, V. Samuel Raj, Xutao Deng, Eric Delwart, Adriana Luchs, Antonio Charlys da Costa, Elcio Leal
Summary: Putative replication-associated protein (REP) and capsid-like (CAP) proteins from CRESS DNA have been found in samples from various eukaryotic groups, but their life cycles and significance in diseases are not well-established. In this study, two full-length CRESS DNA genomes were analyzed from children with acute gastroenteritis in Brazil. The genomes showed similarity to a prior CRESS DNA sequence from a monkey in the United States, indicating a diverse group of porprismacoviruses in South America. The finding of closely related sequences in humans and monkeys highlights the zoonotic potential of these viruses.
Article
Virology
Geovani de Oliveira Ribeiro, Danielle Elise Gill, Endrya do Socorro Foro Ramos, Fabiola Villanova, Edcelha Soares D'Athaide Ribeiro, Fred Julio Costa Monteiro, Vanessa S. Morais, Marlisson Octavio da S. Rego, Emerson Luiz Lima Araujo, Ramendra Pati Pandey, V. Samuel Raj, Xutao Deng, Eric Delwart, Antonio Charlys da Costa, Elcio Leal
Summary: The simultaneous transmission of two lineages of CHIKV was discovered in Brazil. The Asian lineage was restricted to the Amazon region, while the East-Central-South-African lineage expanded across the country. Despite similar climatic conditions and mosquito vector frequencies, the spread of CHIKV differed between states.
Article
Virology
Endrya do Socorro Foro Ramos, Wandercleyson Uchoa Abreu, Luis Reginaldo Ribeiro Rodrigues, Luis Fernando Marinho, Vanessa dos Santos Morais, Fabiola Villanova, Ramendra Pati Pandey, Emerson Luiz Lima Araujo, Xutao Deng, Eric Delwart, Antonio Charlys da Costa, Elcio Leal
Summary: A new CHPV, a recently characterized genus of the Parvoviridae family, was identified in bat samples in North Brazil. The sequences of this CHPV are likely a new species within the genus Chaphamaparvovirus, showing a high level of specificity between CHPV and its hosts.
Article
Microbiology
Juan Lu, Shixing Yang, Chunmei Wang, Hao Wang, Ga Gong, Yuan Xi, Jiamin Pan, Xiaochun Wang, Jian Zeng, Ju Zhang, Peng Li, Quan Shen, Tongling Shan, Wen Zhang
Summary: This study investigated the viral communities in the gut of highland-dwelling Phrynocephalus lizards using viral metagenomic analysis. Bacteriophages, especially of the Caudovirales order, dominated the viral communities of different lizard species. The virome of Phrynocephalus erythrurus had a unique structure with a high abundance of the Parvoviridae family. The study also identified vertebrate-infecting viruses and antibiotic resistance genes. These findings contribute to the understanding of gut viromes in highland lizards and have implications for the protection of threatened species and interspecific differences in commensal viral transmission.
MICROBIOLOGY SPECTRUM
(2022)
