Article
Microbiology
Abbas Karimi, Elham Mohebbi, Sandrine Mckay-Chopin, Hamideh Rashidian, Maryam Hadji, Vahideh Peyghambari, Maryam Marzban, Ahmad Naghibzadeh-Tahami, Mahin Gholipour, Farin Kamangar, Massimo Tommasino, Tarik Gheit, Kazem Zendehdel
Summary: This study analyzed the detection of alpha-, beta-, and gamma-HPVs in oral rinse samples of HNSCC cases and controls in Iran, finding that the contribution of alpha-HPVs to HNSCC in Iran is lower than global prevalence, and high-risk alpha-HPVs or cutaneous beta- and gamma-HPVs were not associated with HNSCC development.
MICROBIOLOGY SPECTRUM
(2022)
Article
Ophthalmology
Ingvild Ramberg, Filipe Garrett Vieira, Peter Bjerre Toft, Christian von Buchwald, Mikkel Funding, Finn Cilius Nielsen, Steffen Heegaard
Summary: The study has identified two potentially distinct distributions of somatic mutations in conjunctival SCC based on HPV status, indicating the significant role of HPV in carcinogenesis in certain cases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Oncology
Xinyi Liu, Ping Liu, Rebecca D. Chernock, Krystle A. Lang Kuhs, James S. Lewis, Hua Li, Hiram A. Gay, Wade L. Thorstad, Xiaowei Wang
Summary: This study identified differences in tumor microenvironment (TME) associated with HPV infection in OPSCC, with enrichment of specific cell types in HPV+ and HPV- OPSCCs. By constructing a coexpression network, it was found that HPV+ OPSCCs exhibit elevated immune activities and suppressed extracellular matrix-related activities compared to HPV- OPSCCs. Clinical analysis showed that TME-relevant genes were closely linked to prognosis and therapy response in OPSCC, with results validated in an independent OPSCC cohort.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Otorhinolaryngology
Evan J. Patel, Jamie R. Oliver, Adam S. Jacobson, Zujun Li, Kenneth S. Hu, Moses Tam, Alec Vaezi, Luc G. T. Morris, Babak Givi
Summary: This historical cohort study reviewed data from the National Cancer Database between 2010 and 2017 to assess the testing rates and prognostic significance of HPV status in hypopharynx malignancies. The results showed that HPV-positive tumors constitute a sizable minority of hypopharynx tumors and are associated with improved survival, suggesting that expansion of HPV testing to hypopharynx malignancies may be warranted.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Letter
Medicine, General & Internal
Nyall R. London, Melina J. Windon, Ameen Amanian, Fernando T. Zamuner, Justin Bishop, Carole Fakhry, Lisa M. Rooper
Summary: This case series examines the occurrence of HPV-associated SNSCC and the prevalence of HPV-positive SNSCC in US adults.
Article
Biochemistry & Molecular Biology
Jaroslav Nunvar, Lucie Pagacova, Zuzana Vojtechova, Nayara Trevisan Doimo de Azevedo, Jana Smahelova, Martina Salakova, Ruth Tachezy
Summary: Our study found that the degree of miRNA deregulation varies significantly among tumors at different locations, and the deregulated miRNAs are largely tumor-specific, with no miRNA shared by all four types of HPV-positive tumors.
Review
Oncology
Kim J. W. Chang Sing Pang, Taha Mur, Louise Collins, Sowmya R. Rao, Daniel L. Faden
Summary: This meta-analysis examines the prevalence of HPV in sinonasal squamous cell carcinoma (SNSCC) and found an overall prevalence of 26%. The study indicated that HPV prevalence was higher in subsites with high exposure to secretion flow and in geographic regions with high HPV+ oropharyngeal squamous cell carcinoma prevalence.
Article
Oncology
Irene H. Nauta, Danielle A. M. Heideman, Arjen Brink, Berdine van der Steen, Elisabeth Bloemena, Senada Koljenovic, Robert J. Baatenburg de Jong, C. Rene Leemans, Ruud H. Brakenhoff
Summary: The prevalence of HPV in oral cavity squamous cell carcinoma is low, and neither HPV status nor p16 status affects outcome, making it seem irrelevant for clinical management to determine HPV status in OCSCC.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Dentistry, Oral Surgery & Medicine
Wafaa Saleh, Seunghee Cha, Abdulaziz Banasser, Sarah G. Fitzpatrick, Indraneel Bhattacharyya, Jilan M. Youssef, Mohamed M. Anees, Islam A. Elzahaby, Joseph Katz
Summary: This study investigated the prevalence and localization of HPV-16 virus in oral squamous cell carcinoma (OSCC) and found a significant correlation between HPV-16 positivity and p16INK4A expression with the clinical and pathological features of OSCC. The highest positivity was observed in the hard palate. The use of p16INK4A as a surrogate marker for HPV detection in OSCC, complemented by RNA ISH for HPV subtyping, is recommended.
Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Article
Health Care Sciences & Services
Hitoshi Hirakawa, Taro Ikegami, Norimoto Kise, Hidetoshi Kinjyo, Shunsuke Kondo, Shinya Agena, Narumi Hasegawa, Junko Kawakami, Hiroyuki Maeda, Mikio Suzuki
Summary: This study investigated the roles of HPV infection and EGFR exon 20 mutations in sinonasal inverted papilloma (IP) and sinonasal squamous cell carcinoma (SNSCC). HPV DNA was found in a significant percentage of IP, IP-SCC, and SNSCC cases, along with p16 overexpression. EGFR exon 20 mutations were observed in IP and IP-SCC cases but not in SNSCC. The phosphorylation pattern of EGFR with exon 20 mutations resembled that of HPV-related SNSCC and oropharyngeal cancer. Further research is needed to understand the etiology of IP-SCC.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Natalia Domian, Grzegorz Mlynarczyk, Irena Kasacka
Summary: The study presented a case of penile squamous cell carcinoma and evaluated the expression of E-cadherin and beta-catenin through immunohistochemical analysis. It was found that E-cadherin expression decreased while beta-catenin expression slightly increased in tumor samples compared to healthy tissue, which may be related to tumor invasion and metastasis. The findings suggest potential roles of E-cadherin and beta-catenin in cell proliferation and adhesion during physiological and pathophysiological processes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Otorhinolaryngology
Alyssa Larish, Linda Yin, Gretchen Glaser, Eric Moore, Jamie Bakkum-Gamez, David Routman, Daniel Ma, Daniel Price, Jeffrey Janus, Katharine Price, Ashish Chintakuntlawar, Michelle Neben-Wittich, Robert Foote, Kathryn Van Abel
Summary: The study found that 37.0% of women with HPV-positive oropharyngeal squamous cell carcinoma had a history of HPV-related anogenital disease, with the cervix being the most common site. Among those with a history, 94.1% required procedures to diagnose or treat HPV lesions.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Otorhinolaryngology
Faris A. Mirza, Christopher Z. Johnson, James Kenneth Byrd, William Greer Albergotti
Summary: This study found that the percentage of locally advanced OPSCC undergoing surgery-based therapy has decreased in both HPV-positive and HPV-negative disease. Factors associated with surgery included younger age, health insurance, and treatment at academic centers.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Review
Oncology
Ryan M. Carr, Zhaohui Jin, Joleen Hubbard
Summary: Anal cancer is a rare disease with increasing incidence rates each year. Significant clinical trials have established the importance of chemotherapy in the treatment of anal cancer. Additionally, the role of immunotherapy in the management of anal cancer is rapidly evolving.
Article
Infectious Diseases
Anneloes L. van Rijn, Roel H. T. Nijhuis, Vincent Bekker, Geert H. Groeneveld, Els Wessels, Mariet C. W. Feltkamp, Eric C. J. Claas
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2018)
Meeting Abstract
Dermatology
L. Syu, D. Wilbert, E. van der Meijden, M. Feltkamp, A. Dlugosz
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Immunology
Sebastiaan Heidt, Mariet C. Feltkamp, Gonca E. Karahan, Caroline S. de Brouwer, Janneke Langerak-Langerak, Arend Mulder, Frans H. J. Claas
Review
Microbiology
Els van der Meijden, Mariet Feltkamp
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Microbiology
Karin J. Purdie, Charlotte M. Proby, Hasan Rizvi, Heather Griffin, John Doorbar, Mary Sommerlad, Mariet C. Feltkamp, Els Van der Meijden, Gareth J. Inman, Andrew P. South, Irene M. Leigh, Catherine A. Harwood
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Virology
Herman F. Wunderink, Caroline S. de Brouwer, Els van der Meijden, Diana Pastrana, Aloysius C. M. Kroes, Christopher B. Buck, Mariet C. W. Feltkamp
JOURNAL OF CLINICAL VIROLOGY
(2019)
Article
Virology
Aline L. van Rijn, Herman F. Wunderink, Caroline S. de Brouwer, Els van der Meijden, Joris I. Rotmans, Mariet C. W. Feltkamp
JOURNAL OF MEDICAL VIROLOGY
(2019)
Article
Hematology
Sergio Kamminga, Els van der Meijden, Caroline de Brouwer, Mariet Feltkamp, Hans Zaaijer
Article
Virology
Ellen C. Carbo, Emilie P. Buddingh, Evita Karelioti, Igor A. Sidorov, Mariet C. W. Feltkamp, Peter A. von dem Borne, Jan J. G. M. Verschuuren, Aloys C. M. Kroes, Eric C. J. Claas, Jutte J. C. de Vries
JOURNAL OF CLINICAL VIROLOGY
(2020)
Article
Dermatology
E. Ghorzang, M. N. C. de Koning, J. N. Bouwes Bavinck, J. Gussekloo, K. D. Quint, J. J. Goeman, M. C. W. Feltkamp, S. C. Bruggink, J. A. H. Eekhof
Summary: This study demonstrates the similarity of HPV types among wart cases, family members, and household linen, showing that HPV1 and HPV2 are more likely to be transmitted to family members and household linen. Dissemination of skin wart-causing HPV types, especially HPV1 and HPV2, from wart cases to household contacts and linen, is highlighted as an important finding deserving further investigation.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Virology
Sergio Kamminga, Aline L. van Rijn, Caroline S. de Brouwer, Joris Rotmans, Hans L. Zaaijer, Mariet C. W. Feltkamp
Summary: This study investigated exposure to JCPyV, MCPyV, TSPyV, and HPyV9 after kidney transplantation by serological means, revealing varying levels of exposure and antibody responses in KTRs.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Microbiology
Marie-Celine Zanella, Damien Pastor, Mariet C. W. Feltkamp, Karine Hadaya, Samuel Cordey, Laurence Toutous Trellu
Summary: This case report describes a patient with primary and disseminated TSPyV infection after kidney transplantation, presenting with extensive skin lesions and high viral loads. The findings suggest potential respiratory and oro-fecal routes of TSPyV transmission.
Article
Multidisciplinary Sciences
Sergio Kamminga, Igor A. Sidorov, Michael Tadesse, Els van der Meijden, Caroline de Brouwer, Hans L. Zaaijer, Mariet C. W. Feltkamp, Alexander E. Gorbalenya
Summary: This study investigated the issues with qPCR assays for human polyomaviruses (HPyVs) and corrected the problematic qPCR performance through in vitro experiments and the use of degenerate oligos. Additionally, it improved the sensitivity of most other qPCRs by adjusting the annealing temperature. The study establishes an efficient framework to ensure confidence in available HPyV qPCRs in the genomic era.
Letter
Medicine, General & Internal
Geert V. T. Roozen, Margaretha L. M. Prins, Rob van Binnendijk, Gerco den Hartog, Vincent P. Kuiper, Corine Prins, Jacqueline J. Janse, Annelieke C. Kruithof, Mariet C. W. Feltkamp, Marjan Kuijer, Frits R. Rosendaal, Meta Roestenberg, Leo G. Visser, Anna H. E. Roukens
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Virology
Sergio Kamminga, Els van der Meijden, Patricia Pesavento, Christopher B. Buck, Mariet C. W. Feltkamp
Summary: The number of identified human polyomaviruses (HPyVs) has been increasing over the past decade. One of these viruses, Lyon-IARC polyomavirus (LIPyV), was found in skin and saliva samples from healthy individuals and is believed to be a feline rather than a human polyomavirus. A comparison of antibody responses among cats, dogs, and humans showed a very high prevalence and intensity of seropositivity for LIPyV in cats, suggesting it is primarily a feline virus.