Article
Gastroenterology & Hepatology
Stefan Schreiber, Shomron Ben-Horin, Jaroslaw Leszczyszyn, Robert Dudkowiak, Adi Lahat, Beata Gawdis-Wojnarska, Aldis Pukitis, Marek Horynski, Katalin Farkas, Jaroslaw Kierkus, Maciej Kowalski, Sang Joon Lee, Sung Hyun Kim, Jee Hye Suh, Mi Rim Kim, Seul Gi Lee, Byong Duk Ye, Walter Reinisch
Summary: This study demonstrated the pharmacokinetic noninferiority of CT-P13 SC to CT-P13 IV, with comparable clinical remission rates between the two formulations.
Article
Gastroenterology & Hepatology
Joshua Kwon, Daniela Fluxa, Francis A. Farraye, Paul T. Kroner
Summary: The study found a significant association between IBD and CMV colitis, with a higher occurrence rate in patients with UC. Patients with CD and CMV colitis had increased odds of mortality, shock, and ICU stay, while patients with UC had a higher likelihood of undergoing colectomy. Patients with IBD and CMV colitis also experienced higher odds of acute kidney injury, multiorgan failure, increased hospital costs, and longer hospital stays compared to those without CMV colitis. Prospectively designed studies are needed to further investigate the risk factors and impact of CMV colitis on IBD patients.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2022)
Review
Infectious Diseases
Keyu Ren, Chunming Yong, Yanting Wang, Hongyun Wei, Kun Zhao, Baoguo He, Mingjuan Cui, Yunqing Chen, Jin Wang
Summary: The objective of this review was to explore the association between CMVP and immunosuppressive therapy in IBD patients, and to emphasize the significance of CMV as an opportunistic pathogen and its potential impact on morbidity and mortality. Records and clinical trajectories related to CMVP in IBD patients were retrieved from the PubMed database, with no language barriers. Our findings showed that CMVP primarily occurs during Crohn's disease remission and azathioprine is the main immunosuppressant linked to CMV reactivation. Prompt antiviral therapy can greatly improve patient outcomes, and CMV vaccine might serve as a potential prevention strategy.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Medicine, General & Internal
Robert B. Gilmore, Kirstin M. Taylor, C. Orla Morrissey, Bradley J. Gardiner
Summary: This article reviews the available literature and outlines a practical approach to the diagnosis and management of cytomegalovirus (CMV) in patients with inflammatory bowel disease (IBD).
INTERNAL MEDICINE JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Anthony Buisson, Maria Nachury, Maud Reymond, Clara Yzet, Pauline Wils, Laure Payen, Marie Laugie, Luc Manlay, Nicolas Mathieu, Bruno Pereira, Mathurin Fumery
Summary: This study assessed the effectiveness of switching from intravenous to subcutaneous infliximab in patients with inflammatory bowel diseases (IBDs). The results showed that switching from intravenous to subcutaneous infliximab was safe and well accepted, with a low risk of relapse in IBD patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Cong Dai, Yu-Hong Huang, Min Jiang
Summary: This study summarizes the current evidence and perspectives on combination therapies in Inflammatory Bowel Diseases (IBD). The combination of infliximab and thiopurines has been shown to be more effective than monotherapy in inducing and maintaining remission in IBD. However, data on the combination of other biological agents and immunosuppressors is lacking or conflicting. Vedolizumab may be an effective maintenance regimen after calcineurin inhibitors-based rescue therapy in acute severe ulcerative colitis (ASUC). Dual Targeted Therapy, which combines two biological agents and/or small molecules, may be a reasonable choice for certain IBD patients but is associated with an increased risk of adverse events and malignancies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Shaden Mahmmod, Johannes P. D. Schultheiss, Ad A. van Bodegraven, Gerard Dijkstra, Lennard P. L. Gilissen, Frank Hoentjen, Maurice W. M. D. Lutgens, Nofel Mahmmod, Andrea E. Van der Meulen-de Jong, Lisa J. T. Smits, Adriaan C. I. T. L. Tan, Bas Oldenburg, Herma H. Fidder
Summary: In a retrospective multicenter cohort study, about 9.9% of IBD patients who were switched from originator infliximab to biosimilar CT-P13 experienced reverse switching, predominantly due to biosimilar-attributed adverse effects. Some patients showed symptom improvement after reverse switching, with a good response seen in those who had lost response to CT-P13.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Camilla de Almeida Martins, Matheus Freitas Cardoso de Azevedo, Alexandre Sousa Carlos, Aderson Omar Mourao Cintra Damiao, Carlos Walter Sobrado Jr, Sergio Carlos Nahas, Natalia Sousa Freitas Queiroz
Summary: This study has enhanced our understanding of the predictive factors of treatment response to IFX in a well-characterized Brazilian IBD population. The study found that the duration of IFX therapy and higher albumin levels increased the likelihood of clinical remission, while previous surgery decreased its chance. Prior use of adalimumab and higher C-reactive protein levels reduced the likelihood of endoscopic remission.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Ruize Liu, Dalin Li, Talin Haritunians, Yunfeng Ruan, Mark J. Daly, Hailiang Huang, Dermot P. B. McGovern
Summary: This study presents a novel molecular-based prediction model that combines genetics, serum biomarkers, and smoking information to assist in the diagnosis of Crohn's disease and ulcerative colitis. The joint model explains approximately 46% of phenotypic variation, with genetics making unique contributions to distinguishing disease subtypes and smoking status potentially not being an effective biomarker.
Article
Gastroenterology & Hepatology
Miikka Hoyhtya, Katri Korpela, Schahzad Saqib, Sofia Junkkari, Eija Nissila, Anne Nikkonen, Evgenia Dikareva, Anne Salonen, Willem M. de Vos, Kaija-Leena Kolho
Summary: This study aimed to investigate the absolute abundances of gut microbiota in relation to the response to induction therapy with infliximab in pediatric inflammatory bowel disease. The results showed that the treatment responsive group had a higher absolute abundance of Bifidobacteriales and a lower absolute abundance of Actinomycetales compared to the nonresponders. However, the level of inflammation according to fecal calprotectin showed no statistically significant association with the absolute abundances of fecal microbiota. The results on relative abundances differed from the absolute abundances.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Guanglin Cui, Qingbo Fan, Zhenfeng Li, Rasmus Goll, Jon Florholmen
Summary: This review discusses the use of TNF antibodies in treating IBD and the evaluation of therapeutic efficacy using current and novel biomarkers. It emphasizes the urgent need for validation and comparison studies of promising novel biomarkers to improve their value in clinical practice.
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Gastroenterology & Hepatology
A. Buisson, M. Nachury, M. Bazoge, C. Yzet, P. Wils, M. Dodel, D. Coban, B. Pereira, M. Fumery
Summary: Switching from intravenous to subcutaneous infliximab can reduce the long-term risk of relapse in patients with inflammatory bowel disease. Close monitoring and dose escalation should be recommended for patients receiving different doses.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Letter
Oncology
Anna Maria Testi, Maria Luisa Moleti, Paola Papoff, Francesca Paoletti, Silvia Trisolini, Maria Stefania De Propris, Simona Bianchi, Francesca Kaiser, Giuseppe Gentile
PEDIATRIC BLOOD & CANCER
(2022)
Article
Cell Biology
Simone Lanini, Stefania Capone, Andrea Antinori, Stefano Milleri, Emanuele Nicastri, Roberto Camerini, Chiara Agrati, Concetta Castilletti, Federica Mori, Alessandra Sacchi, Giulia Matusali, Roberta Gagliardini, Virginia Ammendola, Eleonora Cimini, Fabiana Grazioli, Laura Scorzolini, Federico Napolitano, Maria M. Plazzi, Marco Soriani, Aldo De Luca, Simone Battella, Andrea Sommella, Alessandra M. Contino, Federica Barra, Michela Gentile, Angelo Raggioli, Yufang Shi, Enrico Girardi, Markus Maeurer, Maria R. Capobianchi, Francesco Vaia, Mauro Piacentini, Guido Kroemer, Alessandra Vitelli, Stefano Colloca, Antonella Folgori, Giuseppe Ippolito
Summary: Safe and effective COVID-19 vaccines are crucial for ending the pandemic. A vaccine called GRAd-COV2, based on a gorilla adenovirus and expressing the spike protein of SARS-CoV-2, has been evaluated for safety and immunogenicity in healthy younger and older adults.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Virology
Giulia Matusali, Giuseppe Sberna, Silvia Meschi, Giulia Gramigna, Francesca Colavita, Daniele Lapa, Massimo Francalancia, Aurora Bettini, Maria R. Capobianchi, Vincenzo Puro, Concetta Castilletti, Francesco Vaia, Licia Bordi
Summary: This study investigated the association between binding and functional antibodies in healthcare workers who received two doses of BNT162b2 mRNA COVID-19 vaccine. The results showed a significant correlation between anti-RBD IgG and anti-Trimeric S IgG levels, although there were numerical differences. The levels of anti-RBD IgG decreased significantly at 3 and 6 months after vaccination, while the decrease in anti-Trimeric S IgG levels was less pronounced. Neutralizing antibody titers remained comparable at 3 and 6 months post-vaccination. The study also found that the area under the receiver operating characteristic curve and the optimal cutoff point decreased with time for both anti-RBD and anti-Trimeric S IgG at NAb titers >= 40.
Article
Cell Biology
Tonino Alonzi, Alessandra Aiello, Linda Petrone, Saeid Najafi Fard, Manuela D'Eletto, Laura Falasca, Roberta Nardacci, Federica Rossin, Giovanni Delogu, Concetta Castilletti, Maria Rosaria Capobianchi, Giuseppe Ippolito, Mauro Piacentini, Delia Goletti
Summary: This study found that the aminothiol cysteamine and its oxidation product cystamine have antiviral effects against SARS-CoV-2 and can decrease viral production. Additionally, these compounds have immune-modulatory effects and can reduce the production of specific immune factors in COVID-19 patients. These findings provide a potential rationale for the use of cysteamine and cystamine as a novel therapy for COVID-19.
Article
Infectious Diseases
Licia Bordi, Giuseppe Sberna, Cesira Natalina Piscioneri, Rosario Andrea Cocchiara, Anna Miani, Paola Grammatico, Bruno Mariani, Gabriella Parisi
Summary: This study conducted a large-scale longitudinal study involving healthcare workers to establish the kinetics of immune response over a 9-month period after receiving the second dose of the BNT162b2 vaccine. The research found that the levels of anti-RBD antibodies decreased over time, with females showing a better ability to produce antibodies at 1 and 9 months after vaccination.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Giuseppe Sberna, Eleonora Lalle, Maria Beatrice Valli, Licia Bordi, Anna Rosa Garbuglia, Alessandra Amendola
Summary: A descriptive analysis was conducted on common respiratory pathogens (CRPs) detected in nasopharyngeal swabs (NPSs) from hospitalized patients in the Lazio region of Italy during the fall seasons of 2019-2021. The study aimed to assess whether the circulation of CRPs changed due to COVID-19. The findings showed a variation in CRP circulation over the three-year period, with limited cases in 2020 and a resurgence in 2021, including respiratory syncytial virus (RSV), rhinovirus/enterovirus, and other respiratory pathogens. The study highlights the importance of CRP monitoring for the prevention and control of respiratory infectious diseases, including COVID-19.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Letter
Hematology
Silvia Maria Trisolini, Saveria Capria, Andrea Artoni, Ilaria Mancini, Mario Biglietto, Giuseppe Gentile, Flora Peyvandi, Anna Maria Testi
Article
Oncology
Giovanni Manfredi Assanto, Alice Di Rocco, Francesco Malfona, Marcello Capriata, Ilaria Del Giudice, Luigi Petrucci, Paola Girardi, Gianna Maria D'Elia, Maurizio Martelli, Giuseppe Gentile, Alessandra Micozzi, Alessandro Pulsoni
Summary: COVID-19 in lymphoma patients has a high mortality rate, but treatment with anti-SARS-CoV-2 monoclonal antibodies can decrease mortality, reduce complications, and decrease the need for oxygen support. The use of anti-COVID antibodies in vaccinated patients may improve survival rates. Active hematological disease, exposure to bendamustine, and comorbidities are independent factors predicting death.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Infectious Diseases
Alessandra Micozzi, Clara Minotti, Saveria Capria, Claudio Cartoni, Silvia Maria Trisolini, Giovanni Manfredi Assanto, Walter Barberi, Maria Luisa Moleti, Stefania Santilli, Maurizio Martelli, Giuseppe Gentile
Summary: The purpose of this study was to evaluate the benefits and safety of empiric antibiotic treatment (EAT) active against KPC-K. pneumoniae in febrile neutropenic patients with acute leukemia (AL) who are colonized by KPC-K. pneumoniae. The results showed that EAT with CAZAVI-based combinations had better outcomes compared to colistin-based EAT. CAZAVI-containing EAT was the independent factor for an overall successful response.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biochemistry & Molecular Biology
Licia Bordi, Giuseppe Sberna, Eleonora Lalle, Lavinia Fabeni, Valentina Mazzotta, Simone Lanini, Angela Corpolongo, Anna Rosa Garbuglia, Emanuele Nicastri, Enrico Girardi, Francesco Vaia, Andrea Antinori, Fabrizio Maggi
Summary: The study compared the detection of the SARS-CoV-2 Omicron variant in nasopharyngeal-swab (NPS) and oral saliva samples. Results showed good agreement between the two types of samples, with a significant correlation among cycle threshold values. The study also found that saliva can be used as an alternative specimen for the detection and follow-up of Omicron-infected patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Giuseppe Frieri, Marco Valvano, Sara Frassino, Susanna Faenza, Nicola Cesaro, Gianfranco Amicucci, Rosa Manetta, Angelo Viscido, Giovanni Latella
Summary: About 50% of CD patients undergo intestinal resection, and 40% of those experience postoperative recurrence within 5 years. This case series aimed to evaluate the incidence of recurrence in CD patients with high risk and prophylactic treatment using Vedolizumab. Magnetic resonance enterography was used to assess the patients after surgical resection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Mauro Passucci, Chiara Masucci, Francesca Paoletti, Claudia Ielo, Alessandro Costa, Ida Carmosino, Emilia Scalzulli, Maurizio Martelli, Giuseppe Gentile, Massimo Breccia
Summary: Patients with hematological malignancies and past serological evidence of hepatitis B are at risk for HBV reactivation. The use of the JAK 1/2 inhibitor ruxolitinib in myeloproliferative neoplasms carries a moderate risk of reactivation (1-10%), but there is no strong evidence to recommend HBV prophylaxis in these patients. This case report highlights the potential need for continued HBV prophylaxis in patients receiving ruxolitinib treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Nutrition & Dietetics
Marco Valvano, Annalisa Capannolo, Nicola Cesaro, Gianpiero Stefanelli, Stefano Fabiani, Sara Frassino, Sabrina Monaco, Marco Magistroni, Angelo Viscido, Giovanni Latella
Summary: Inflammatory Bowel Disease patients often experience malnutrition, undernutrition, or overnutrition during the disease course, which is mainly caused by suboptimal nutritional intake, alterations in nutrient requirements and metabolism, malabsorption, and excessive gastrointestinal losses. Suboptimal nutritional status and low micronutrient serum levels have a negative impact on disease remission, maintenance, and quality of life in Inflammatory Bowel Disease patients. A systematic review of studies evaluating the connection between nutrition and disease course in patients with Inflammatory Bowel Disease revealed potential nutritional aspects that can improve symptom control and overall quality of life.
Article
Gastroenterology & Hepatology
M. Valvano, V. Vezzaro, S. Fabiani, A. Capannolo, E. Sgamma, N. Cesaro, G. Valerii, S. Longo, C. Barbera, L. Lombardi, A. Viscido, S. Necozione, G. Latella
Summary: This study aimed to evaluate the association between diverticulosis and colonic neoplastic lesions. It found a significant association between diverticulosis and colonic adenomas. However, no causal relationship could be established due to the study design. Further prospective studies are needed to clarify this clinical question.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Review
Medicine, General & Internal
Filippo Vernia, Hassan Ashktorab, Nicola Cesaro, Sabrina Monaco, Susanna Faenza, Emanuele Sgamma, Angelo Viscido, Giovanni Latella
Summary: This narrative review provides an overview of the pathophysiology and clinical manifestations of gastrointestinal COVID-19, highlighting the direct infection of the gastrointestinal tract by SARS-CoV-2 and the resulting symptoms.
MEDICINA-LITHUANIA
(2023)