Article
Behavioral Sciences
Jose M. Rubio, Anil K. Malhotra, John M. Kane
Summary: Schizophrenia is a chronic disorder that often requires long-term relapse-prevention treatment, but current approach may not be optimal for all patients. There is a need to identify biomarkers of relapse in schizophrenia for personalized treatment and develop therapeutics targeting its pathophysiology.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Ana M. Sanchez-Torres, Silvia Amoretti, Monica Enguita-German, Gisela Mezquida, Lucia Moreno-Izco, Rocio Panadero-Gomez, Lide Rementeria, Alba Toll, Roberto Rodriguez-Jimenez, Alexandra Roldan, Edith Pomarol-Clotet, Angela Ibanez, Judith Usall, Fernando Contreras, Eduard Vieta, Jose M. Lopez-Ilundain, Jessica Merchan-Naranjo, Ana Gonzalez-Pinto, Esther Berrocoso, Miguel Bernardo, Manuel J. Cuesta
Summary: This study aimed to investigate the relationship between relapse, cognitive function, and cognitive reserve in schizophrenia patients. The results showed that higher personal cognitive reserve mitigated the negative effects of relapse on attention performance, while higher cognitive reserve (both personal and familial) improved processing speed and visual memory in patients who did not relapse. These findings provide evidence for the protective effect of cognitive reserve over the course of the illness.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Medical Laboratory Technology
Song Lin, Ping Li, Jinglei Qin, Qi Liu, Jinling Zhang, Nana Meng, Cuicui Jia, Kunjie Zhu, Dan Lv, Lei Sun, Tinghuizi Shang, Yan Lin, Weipan Niu, Tianyang Wang
Summary: This study used the integration of LC-MS and 1H NMR metabolomics to establish a weighted correlation network, and identified key factors in accelerating schizophrenia relapse. The cluster 1, composed of 139 metabolites involved in lipid metabolism and energy metabolism, was found to be the most important subnetwork relevant to schizophrenia relapse. Phenylalanylphenylalanine was recommended as the key biomarker related to schizophrenia relapse, and it was found to affect the progression of schizophrenia through intervention in energy metabolism.
CLINICA CHIMICA ACTA
(2023)
Article
Psychiatry
Kristian Tore Jorgensen, Martin Bog, Madhu Kabra, Jacob Simonsen, Michael Adair, Linus Jonsson
Summary: This study used real-world data to analyze relapse in patients with schizophrenia, finding a significant relationship between the number of prior relapses and the time to next relapse, highlighting the importance of early and effective treatment interventions tailored to individual patient needs.
Article
Psychiatry
Margarita M. Maramis, Muhammad Sofyan Almahdy, Atika Atika, Cokorda Bagus Jaya Lesmana, Jakobus Gerick Pantouw
Summary: This study identified that factors such as a history of physical diseases in mothers during pregnancy, presence of triggers, negative beliefs, and hereditary factors significantly influenced the relapse of patients with schizophrenia. These factors are important to predict and prevent relapse in patients with schizophrenia.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2022)
Article
Psychiatry
Mushde Shakir, Anne E. Willems, Peter N. van Harten, Remko van Lutterveld, Diederik E. Tenback
Summary: Switching from a combination of first- and second-generation antipsychotics to monotherapy does not increase the relapse rate and may even reduce it in long-term inpatients.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Sandeep Grover, Chandrima Naskar, Subho Chakrabarti
Summary: The study found that clozapine nonresponders, compared to responders, were more likely to be unemployed at the start of clozapine and had more medical comorbidities. While approximately one-third of patients with TRS do not respond to clozapine, nonresponders differ significantly in past treatment profile.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Elena Rodriguez-Villa, Urvakhsh Meherwan Mehta, John Naslund, Deepak Tugnawat, Snehil Gupta, Jagadisha Thirtalli, Anant Bhan, Vikram Patel, Prabhat Kumar Chand, Abhijit Rozatkar, Matcheri Keshavan, John Torous
Summary: Predicting and preventing relapse in persons living with schizophrenia presents a crucial opportunity. The Smartphone Health Assessment for Relapse Prevention (SHARP) study aims to develop a digital health solution to monitor personal risk of relapse and help individuals diagnosed with serious mental illness. By collecting real-time data through smartphones and smartwatches, personalized relapse signals can be explored to optimize mental health resources globally.
Article
Psychiatry
Benjamin Buck, Kevin A. Hallgren, Andrew T. Campbell, Tanzeem Choudhury, John M. Kane, Dror Ben-Zeev
Summary: The study found that patients gradually reported increases in persecutory ideation and hallucinations in the 100 days preceding relapse, suggesting that elevations in negative mood, anxiety, persecutory ideation, and hallucinations were significantly higher on relapse days compared to their average levels. Therefore, brief assessments of psychotic symptoms may detect meaningful signals long before psychiatric relapses occur.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Environmental Sciences
Jiaojiao Gao, Qiannan Wei, Rubing Pan, Weizhuo Yi, Zihan Xu, Jun Duan, Chao Tang, Yangyang He, Xiangguo Liu, Shasha Song, Hong Su
Summary: This study found a positive association between environmental PM2.5 and the risk of relapse in schizophrenia through a repeated-measures design, with the immune cytokine IL-17 potentially mediating this relationship. Increased PM2.5 had a significant impact on symptom dimensions of schizophrenia, particularly in terms of depression and anxiety.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Health Care Sciences & Services
Ana A. Miron, Petru I. Ifteni, Andreea Teodorescu, Paula S. Petric
Summary: The COVID-19 pandemic has had an impact on the initiation of long acting injectable antipsychotics (LAIs), leading to a significant decrease in the number of LAIs initiations. This could have an important impact on the relapse rate of patients with schizophrenia.
Article
Nursing
Qing Wang, Xiaodan Zhu, Xiaojian Jiang, Meizhi Li, Ru Chang, Bing Chen, Juan Liu
Summary: The study revealed a close relationship between coping styles of patients with schizophrenia and the risk of relapse, with positive coping reducing the likelihood of relapse and negative coping potentially increasing it. Furthermore, positive and negative coping were shown to have moderating effects on the impact of stressful life events on schizophrenia relapse, although the effect was relatively weak.
INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
(2021)
Article
Social Sciences, Mathematical Methods
Roderick J. Little
Summary: This study proposes a definition of response propensity for nonresponse adjustments and justifies it from both design-based and model-based perspectives. The role of the missing at random assumption is discussed in cross-sectional surveys and longitudinal surveys with attrition.
JOURNAL OF SURVEY STATISTICS AND METHODOLOGY
(2022)
Article
Psychiatry
Robert A. McCutcheon, David Taylor, Jose Rubio, Joseph Nour, Toby Pillinger, Robin M. Murray, Sameer Jauhar
Summary: This study found that discontinuation of antipsychotic medication is associated with an increased risk of relapse in schizophrenia, which is related to receptor occupancy. Although the rate of discontinuation does not appear to affect relapse, gradual discontinuation strategies may facilitate easier reinstatement of antipsychotic medication in case of symptomatic worsening.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Multidisciplinary Sciences
Tim A. Bruckner, Daniel M. Parker, Scott M. Bartell, Veronica M. Vieira, Saahir Khan, Andrew Noymer, Emily Drum, Bruce Albala, Matthew Zahn, Bernadette Boden-Albala
Summary: Clinic-based estimates may underestimate total SARS-CoV-2 infections due to variability in testing access and symptoms. The study aimed to provide a minimally biased estimate of seroprevalence by recruiting adults for testing. Results showed a seroprevalence of around 12%, higher among Hispanics and those with lower household income. The study used a specific and sensitive microarray technology, revealing a significantly higher prevalence compared to official statistics.
SCIENTIFIC REPORTS
(2021)
Article
Rehabilitation
Riekie Engelbrecht, Nicola Plastow, Ulla Botha, Djh Niehaus, Liezl Koen
DISABILITY AND REHABILITATION
(2019)
Article
Education & Educational Research
Caro De Witt, Inge Smit, Esme Jordaan, Liezl Koen, Dana J. H. Niehaus, Ulla Botha
BMC MEDICAL EDUCATION
(2019)
Article
Psychiatry
Durk P. Aartsma, Engelina Groenewald, Liezl Koen, Felix Potocnik, Dana J. Niehaus
SOUTH AFRICAN JOURNAL OF PSYCHIATRY
(2019)
Article
Multidisciplinary Sciences
Juha Pyykko, Per Ashorn, Ulla Ashorn, Dana J. H. Niehaus, Jukka M. Leppanen
SCIENTIFIC REPORTS
(2019)
Review
Clinical Neurology
Marlette Burger, Munira Hoosain, Christa Einspieler, Marianne Unger, Dana Niehaus
JOURNAL OF AFFECTIVE DISORDERS
(2020)
Article
Psychiatry
Anthea Payne, Liezl Koen, Daniel J. H. Niehaus, Inge-Marli Smit
SOUTH AFRICAN JOURNAL OF PSYCHIATRY
(2020)
Article
Psychiatry
Elsa du Toit, Dana Niehaus, Esme Jordaan, Liezl Koen, Roxane Jones, Jukka Leppanen
SOUTH AFRICAN JOURNAL OF PSYCHIATRY
(2020)
Article
Psychiatry
Henmar F. Botha, Liezl Koen, Daniel J. H. Niehaus, Yanga Vava, Karis Moxley, Ulla Botha
SOUTH AFRICAN JOURNAL OF PSYCHIATRY
(2020)
Article
Psychology, Educational
Santeri Yrttiaho, Belinda Bruwer, Heather J. Zar, Kirsten A. Donald, Susan Malcolm-Smith, Lee Ginton, Nadia Hoffman, Eileen Vuong, Dana Niehaus, Jukka M. Leppanen, Dan J. Stein
Summary: Two studies conducted in South African mothers from different socioeconomic backgrounds revealed differences in maternal physiological and attentional responses to infant distress expressions, indicating the impact of socioeconomic status.
Article
Education & Educational Research
Anusha Lachman, Dana J. H. Niehaus, Esme R. Jordaan, Jukka Leppanen, Kaija Puura, Belinda Bruwer
Summary: Infant mental health is strongly influenced by the relationship between the infant and a responsive caregiver. Maternal mental illness can hinder the mother's ability to perceive and respond to the infant's cues, affecting attachment and emotion regulation. Shared Pleasure moments can be used as a screening marker for at-risk dyads, with younger infants and mothers without mental illness or who are married having more frequent SP moments.
EARLY CHILD DEVELOPMENT AND CARE
(2021)
Article
Psychology, Multidisciplinary
Aicha Kivinummi, Gaurav Naithani, Outi Tammela, Tuomas Virtanen, Enni Kurkela, Miia Alhainen, Dana J. H. Niehaus, Anusha Lachman, Jukka M. Leppanen, Mikko J. Peltola
FRONTIERS IN PSYCHOLOGY
(2020)
Article
Psychology, Developmental
Dana Niehaus, Esme Jordaan, Riana Laubscher, Taryn Sutherland, Liezl Koen, Felix Potocnik
GEROPSYCH-THE JOURNAL OF GERONTOPSYCHOLOGY AND GERIATRIC PSYCHIATRY
(2020)
Correction
Primary Health Care
Zimbini Ogle, Liezl Koen, Dana J. H. Niehaus
AFRICAN JOURNAL OF PRIMARY HEALTH CARE & FAMILY MEDICINE
(2019)
Article
Pharmacology & Pharmacy
Felix C. V. Potocnik, Dana Niehaus
SA PHARMACEUTICAL JOURNAL
(2018)
Review
Psychology, Developmental
Juane Voges, Astrid Berg, Dana J. H. Niehaus
INFANT MENTAL HEALTH JOURNAL
(2019)