Article
Psychiatry
Alqassem Y. Hakami, Razaz Felemban, Rami Ghazi Ahmad, Abdulrahman H. Al-Samadani, Hassan K. Salamatullah, Jamil M. Baljoon, Loay J. Alghamdi, Mostafa H. Ramadani Sindi, Mohamed Eldigire Ahmed
Summary: This study investigated the impact of antipsychotics use on weight gain and found that the concomitant use of metformin may significantly reduce the occurrence of AIWG.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Maarten Bak, Marjan Drukker, Shauna Cortenraad, Emma Vandenberk, Sinan Guloksuz
Summary: This meta-analysis found that antipsychotics are associated with body weight gain, regardless of psychiatric diagnosis.
Article
Health Care Sciences & Services
Diana Z. Paderina, Anastasiia S. Boiko, Ivan V. Pozhidaev, Anna V. Bocharova, Irina A. Mednova, Olga Yu. Fedorenko, Elena G. Kornetova, Anton J. M. Loonen, Arkadiy V. Semke, Nikolay A. Bokhan, Svetlana A. Ivanova
Summary: The study investigated the association of nine polymorphisms in serotonergic system genes with MetS in patients with schizophrenia. Results suggested that allelic variants of HTR2C genes may affect metabolic parameters, and MetS is too complex to be studied without dissecting it into individual components.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Psychiatry
Zeeshan Mansuri, Ramkrishna Makani, Chintan Trivedi, Mahwish Adnan, Ramu Vadukapuram, John Rafael, Ashutosh Lodhi, Abhishek Reddy
Summary: Metformin may have beneficial effects in treating weight gain in children treated with second-generation antipsychotics, with significant reductions in weight and BMI Z-score observed within 12-16 weeks. However, the use of metformin may increase the likelihood of nausea-vomiting and diarrhea as side effects.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Genetics & Heredity
Yang Zhang, Laidi Wang, Jijie Li, Qiang Bao, Yong Zhang, Guobin Chang, Guohong Chen
Summary: The genotypes and gene frequencies of five candidate genes related to egg production were analyzed, and no significant differences were found in the Yangzhou goose population. However, higher annual egg production was observed in genotypes AC at ACSF2 and TT at KIAA1462, while higher body weight was observed in genotype TT at ARHGAP21.
Article
Medicine, General & Internal
Bruna Panizzutti, Chiara C. Bortolasci, Briana Spolding, Srisaiyini Kidnapillai, Timothy Connor, Mark F. Richardson, Trang T. T. Truong, Zoe S. J. Liu, Laura Gray, Jee Hyun Kim, Olivia M. Dean, Michael Berk, Ken Walder
Summary: Studies reveal that antipsychotic drugs can affect gene expression related to lipid biosynthesis and metabolism, potentially influencing weight gain and metabolic syndrome. Regulation of SREBF1/SREBF2 expression by these drugs may play a role in lipid metabolism and metabolic alterations, offering insights for personalized treatment approaches in schizophrenia patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Shangang Zhao, Qian Lin, Wei Xiong, Li Li, Leon Straub, Dinghong Zhang, Rizaldy Zapata, Qingzhang Zhu, Xue-Nan Sun, Zhuzhen Zhang, Jan-Bernd Funcke, Chao Li, Shiuhwei Chen, Yi Zhu, Nisi Jiang, Guannan Li, Ziying Xu, Steven C. Wyler, May-Yun Wang, Juli Bai, Xianlin Han, Christine M. Kusminski, Ningyan Zhang, Zhiqiang An, Joel K. Elmquist, Olivia Osborn, Chen Liu, Philipp E. Scherer
Summary: Antipsychotic drugs can cause weight gain and diabetes, and hyperleptinemia plays a key role. Suppression of leptin rise can reduce the adverse effects of these drugs.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Weixiang Wu, Dan Luo, Xiaolin Ruan, Chunming Gu, Weiming Lu, Kailing Lian, Xiaoping Mu
Summary: The study suggests a potential relationship between gestational weight gain (GWG) and adverse birth outcomes, with potential modification by maternal genetic polymorphisms. GWG categories are closely related to LBW, macrosomia, SGA, and LGA, and their associations may be modified by the MTHFR A1298C polymorphism among pregnant women.
FRONTIERS IN NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Yiwen Zhu, Franca Centorrino, John W. Jackson, Garrett M. Fitzmaurice, Linda Valeri
Summary: The study utilized meta-analytic causal mediation analysis to combine evidence from multiple studies and enhance statistical power. Results indicate that positive symptoms play a significant mediating role in the treatment effect of negative symptoms, while weight gain may have beneficial mediating effects but could diminish at high doses with excessive metabolic side effects.
Article
Psychiatry
Jiwon Lee, Kenya Costa-Dookhan, Kristoffer Panganiban, Nicole MacKenzie, Quinn Casuccio Treen, Araba Chintoh, Gary Remington, Daniel J. J. Mueller, Sanjeev Sockalingam, Philip Gerretsen, Marcos Sanches, Alla Karnovsky, Kathleen A. Stringer, Vicki L. L. Ellingrod, Ivy F. F. Tso, Stephan F. F. Taylor, Sri Mahavir Agarwal, Margaret K. K. Hahn, Kristen M. M. Ward
Summary: Psychosis spectrum disorders (PSDs) and other severe mental illnesses like bipolar disorder are associated with intrinsic metabolic abnormalities. Antipsychotics (APs), the main treatment for PSDs, can lead to additional metabolic issues including weight gain. This study used metabolomic profiles to identify biomarkers and explore the mechanisms of PSDs and AP-induced weight gain. The findings suggest that specific fatty acids may serve as biomarkers for PSDs and early predictors of AP-induced weight gain. These findings have important clinical implications for identifying individuals at risk and developing targeted treatments.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Pollyanna Patriota, Serge Rezzi, Idris Guessous, Pedro Marques-Vidal
Summary: This population-based prospective cohort study found no association between vitamin D levels and changes in weight and waist circumference at 5- and 10-year follow-up.
Article
Agriculture, Dairy & Animal Science
Deyin Zhang, Xiaoxue Zhang, Fadi Li, Yongfu La, Guoze Li, Yukun Zhang, Xiaolong Li, Yuan Zhao, Qizhi Song, Weimin Wang
Summary: This study analyzed the effects of PPARGC1B and ZEB2 gene polymorphisms on body weight in Hu sheep. The results showed that these polymorphisms were significantly associated with body weight, with individuals carrying specific genotypes having higher body weight. Therefore, the polymorphisms in PPARGC1B and ZEB2 genes can be used as candidate molecular markers for breeding desirable growth traits in Hu sheep.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Thais Rangel Bousquet Carrilho, Jennifer A. Hutcheon, Kathleen M. Rasmussen, Michael E. Reichenheim, Dayana Rodrigues Farias, Nathalia Cristina Freitas-Costa, Gilberto Kac
Summary: This study aimed to determine the ranges of gestational weight gain (GWG) associated with the lowest risks of adverse maternal and infant outcomes using Brazilian GWG charts. The findings showed that GWG z-scores were associated with large-for-gestational-age (LGA) and small-for-gestational-age (SGA) births, indicating the importance of GWG range in affecting maternal and neonatal outcomes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Psychiatry
Xinyu Fang, Chunying Gao, Weifeng Wu, Xiuxiu Hu, Miaomiao Shao, Chou Zhou, Renliang Cai, Jin Fang, Yi Li, Yue Xu, Xiangrong Zhang
Summary: This study explored the relationship between weight gain in schizophrenia patients with atypical antipsychotic treatment and gut microbiome. The results showed that there were no significant differences in alpha diversity between normal-weight and overweight schizophrenia patients treated with atypical antipsychotics. However, the beta diversity analysis revealed distinct clustering patterns for overweight and normal-weight patients. The composition of the gut microbiome also differed between the two groups. Function prediction identified several pathways that were significantly different between groups. Correlation analysis indicated associations between specific bacteria and BMI. Overall, these findings suggest that perturbations in the gut microbiome composition and functional pathways may contribute to weight gain in schizophrenia patients treated with atypical antipsychotics.
PSYCHIATRY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Kenya A. Costa-Dookhan, Tarek K. Rajji, Veronica N. Tran, Sylvie Bowden, Daniel J. Mueller, Gary J. Remington, Sri Mahavir Agarwal, Margaret K. Hahn
Summary: Clozapine is an effective antipsychotic for ultra-treatment resistant schizophrenia but limited by metabolic dysfunction. The ratio of Clozapine to its main metabolite N-desmethylclozapine is associated with insulin resistance and cognitive functioning. The study suggests that the CLZ/NDMC ratio may predict insulin resistance and metabolic comorbidity in patients with TRS receiving clozapine.
SCIENTIFIC REPORTS
(2021)