Article
Health Care Sciences & Services
Diana Z. Paderina, Anastasiia S. Boiko, Ivan V. Pozhidaev, Anna V. Bocharova, Irina A. Mednova, Olga Yu. Fedorenko, Elena G. Kornetova, Anton J. M. Loonen, Arkadiy V. Semke, Nikolay A. Bokhan, Svetlana A. Ivanova
Summary: The study investigated the association of nine polymorphisms in serotonergic system genes with MetS in patients with schizophrenia. Results suggested that allelic variants of HTR2C genes may affect metabolic parameters, and MetS is too complex to be studied without dissecting it into individual components.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Nutrition & Dietetics
Lucia Manfredi, Alessandra Accoto, Alessandro Couyoumdjian, David Conversi
Summary: This systematic review focuses on the genetic polymorphisms related to binge eating disorder (BED), highlighting potentially useful polymorphisms such as 5-HTTLPR, Taq1A, A118G, C957T, rs2283265, Val158Met, rs6198, Val103Ile, Ile251Leu, rs6265, and Leu72Met. Among these, Taq1A showed the most significant association with BED according to the research. Additional evidence is needed to confirm the impact of the other polymorphisms.
Article
Medicine, General & Internal
Elizabeth Mostel, Savan Patel, Brian G. Wiener
Summary: Serotonin toxicity, also known as serotonin syndrome, is a drug-induced condition that can occur in patients taking multiple medications. This report describes a case of a 70-year-old female patient who developed serotonin toxicity symptoms due to treatment with paroxetine and quetiapine, and ultimately recovered after discontinuing the offending agents and receiving appropriate treatment.
AMERICAN JOURNAL OF CASE REPORTS
(2022)
Article
Psychiatry
Hanga Galfalvy, Eileen Shea, Jacqueline de Vegvar, Spiro Pantazatos, Yung-yu Huang, Ainsley K. Burke, M. Elizabeth Sublette, Maria A. Oquendo, Francesca Zanderigo, Jeffrey M. Miller, J. John Mann
Summary: Childhood and lifetime adversity may influence brain serotonergic neurotransmission through epigenetic mechanisms. This study found that recent stress was correlated with DNA methylation of the 5-HT1A receptor gene and binding potential in participants with major depressive disorder (MDD), but not in controls. Childhood adversity was not associated with methylation or binding potential in MDD participants.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Cell Biology
Weiwei Chu, Shang Li, Xueying Geng, Dongshuang Wang, Junyu Zhai, Gang Lu, Wai-Yee Chan, Zi-Jiang Chen, Yanzhi Du
Summary: This study investigates the impact of environmental circadian rhythm disruption on the development of PCOS and identifies the roles of MTNR1A and AR in the progression of hyperandrogenism in PCOS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Winston H. Cuddleston, Junhao Li, Xuanjia Fan, Alexey Kozenkov, Matthew Lalli, Shahrukh Khalique, Stella Dracheva, Eran A. Mukamel, Michael S. Breen
Summary: This study investigates RNA editing in different cell populations of the human prefrontal cortex and reveals selective and highly cell type-specific RNA editing in neurons. The findings provide insights into the functional roles of RNA editing in the brain and its implications for brain disorders.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kenneth Dahl, Peter Johnstrom, Anton Forsberg-Moren, Bjorn Gustafsson, Patricia Miranda-Azpiazu, Yaser Khani, Christer Halldin, Lars Farde, Charles S. Elmore, Magnus Schou
Summary: This study reports the preparation and evaluation of two candidate 5-HT1A radioligands in vitro and in vivo. Although one of the radioligands showed high specific binding in human brain tissue, its regional binding potential values in cynomolgus monkey brain were low, suggesting it is not suitable for further investigation.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Yuhe Fan, Yuting Yang, Lele Shi, Wenping Zhao, Feng Kong, Pingyuan Gong
Summary: Serotonin affects mental health and well-being. By studying the genetic variations in the serotonin pathway, we found that the cumulative genetic score is related to individual differences in well-being, while the effects of individual genetic polymorphisms are not significant. Specifically, individuals with a higher cumulative genetic score, indicating a lower risk of depression, tend to have higher levels of subjective and psychological well-being. These findings suggest that the overall serotoninergic genetic profile, rather than specific genetic polymorphisms, greatly influences individual well-being.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Psychiatry
Elizabeth A. A. Bartlett, Ashley A. A. Yttredahl, Maura Boldrini, Andrea E. E. Tyrer, Kathryn R. R. Hill, Mala R. R. Ananth, Matthew S. S. Milak, Maria A. A. Oquendo, J. John Mann, Christine DeLorenzo, Ramin V. V. Parsey
Summary: This study found that childhood adversity is associated with the development and severity of depression in adulthood. However, the elevated serotonin 1A receptor (5-HT1AR) binding potential, which has been linked to major depression, was not replicated in this study. The findings suggest that childhood adversity may induce long-lasting changes in the expression of 5-HT1AR. The elevated hippocampal 5-HT1AR binding potential may serve as a promising biomarker to investigate the neurobiological link between childhood adversity and depression.
EUROPEAN PSYCHIATRY
(2023)
Article
Clinical Neurology
Gordana Nedic Erjavec, Lucija Tudor, Matea Nikolac Perkovic, Josip Podobnik, Katarina Dodig Curkovic, Mario Curkovic, Dubravka Svob Strac, Melita Cusek, Marco Bortolato, Nela Pivac
Summary: This study found an association between genetic polymorphisms of the 5-HT2A receptor and conduct disorder (CD). Certain genetic variations were strongly linked to irritability, physical aggression, and antisocial behavior. Additionally, CD subjects had significantly higher platelet 5-HT concentrations, which correlated with smoking status.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Clinical Neurology
Elizabeth A. Bartlett, Francesca Zanderigo, Barbara Stanley, Tse-Hwei Choo, Hanga C. Galfalvy, Spiro P. Pantazatos, Jeffrey M. Miller, Maria A. Oquendo, J. John Mann
Summary: This study investigated the relationship between the serotonin system and stress in major depression and suicidal behavior. The results showed that suicide attempters had lower binding potential to 5-HTT and higher binding potential to 5-HT1A in certain brain regions compared to non-attempters, and these differences were associated with their stress levels. These findings suggest that the changes in 5-HTT and 5-HT1A may serve as biological markers for the risk of suicidal behavior.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sugandha Gupta, Mengya Wang, Yoshiaki Azuma, Nancy A. Muma
Summary: This study reveals two mechanisms regulating SUMOylation of 5-HT1ARs, by agonists and EB, and two key enzymes, PIASx alpha and SENP2, involved in this process. The findings demonstrate that these mechanisms differ based on treatment with agonists and EB. Targeting the SUMOylation of 5-HT1ARs could have important clinical relevance for the therapy of several neuropsychiatric disorders involving 5-HT1ARs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Jean-Baptiste Quilichini, Alexis Revet, Philippe Garcia, Regis Bouquie, Jacques Hamard, Antoine Yrondi, Francois Montastruc
Summary: This study found that the use of short half-life antidepressants is associated with an increased risk of reporting withdrawal syndrome compared to long half-life antidepressants in patients. Especially for patients aged 18-44, women, and those treated with Paroxetine, Desvenlafaxine, Venlafaxine, and Duloxetine. These findings provide guidance for clinical practice.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Rosa J. Chen, Anika Nabila, Swati Phalke, Danny Flores Castro, Judit Gal Toth, Paul Bergin, Jeroen Bastiaans, Heidi Stuhlmann, Alessandra B. Pernis, Miklos Toth
Summary: This study reveals that 5HT1AR deficit leads to immune abnormalities in the maternal system, which in turn affects the in utero environment and results in sex-biased outcomes.
Article
Clinical Neurology
Tristan J. Philippe, Lexia Bao, Maya E. Koblanski, Victor Viau
Summary: This study found that male and female rats showed region-specific changes in 5-HT 1A receptor function after repeated restraint, which may be explained by changes in receptor availability.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)